Exploitation of the host cell ubiquitin machinery by microbial effector proteins

Mechanisms of regulation and diversification of deubiquitylating enzyme function

(2017) Pawel Leznicki et al.   JOURNAL OF CELL SCIENCE

Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases

(2017) Alexander F. A. Keszei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Mimicry by a Bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System

(2017) Kathy Wong et al.   STRUCTURE

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

(2016) Jonathan N. Pruneda et al.   MOLECULAR CELL

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members

(2016) Jana Kamanova et al.   PLoS Pathogens

Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria

(2016) Hiroshi Ashida et al.   Frontiers in Cellular and Infection Microbiology

Crystal structure of the substrate-recognition domain of theShigellaE3 ligase IpaH9.8

(2016) Kenji Takagi et al.   Acta Crystallographica Section F-Structural Biology Communications

Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation

(2016) Maarten F. de Jong et al.   Nature Microbiology

Host Cell-catalyzedS-Palmitoylation Mediates Golgi Targeting of theLegionellaUbiquitin Ligase GobX

(2015) Yi-Han Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial E3 Ubiquitin Ligase IpaH4.5 ofShigella flexneriTargets TBK1 To Dampen the Host Antibacterial Response

(2015) Zirui Zheng et al.   JOURNAL OF IMMUNOLOGY

Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination

(2015) Michael J. Sheedlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila

(2015) Andrew T. Quaile et al.   STRUCTURE

Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways

(2015) Peter Wimmer et al.   Viruses-Basel

Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome

(2015) Xi Luo et al.   PLoS Pathogens

Arabidopsis HFR1 Is a Potential Nuclear Substrate Regulated by the Xanthomonas Type III Effector XopDXcc8004

(2015) Choon Meng Tan et al.   PLoS One

Identification of TRAF6 as a ubiquitin ligase engaged in the ubiquitination of SopB, a virulence effector protein secreted by Salmonella typhimurium

(2014) Hai-Hua Ruan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The structure of the Slrp–Trx1 complex sheds light on the autoinhibition mechanism of the type III secretion system effectors of the NEL family

(2014) Samira Zouhir et al.   BIOCHEMICAL JOURNAL

E2~Ub conjugates regulate the kinase activity ofShigellaeffector OspG during pathogenesis

(2014) Jonathan N Pruneda et al.   EMBO JOURNAL

Ubiquitin Activates Patatin-Like Phospholipases from Multiple Bacterial Species

(2014) David M. Anderson et al.   JOURNAL OF BACTERIOLOGY

Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF- B, Suppresses I B  Ubiquitination and Modulates Innate Immune Responses

(2014) G. Le Negrate et al.   JOURNAL OF IMMUNOLOGY

The structure of the N-terminal domain of the Legionella protein SidC

(2014) Emerich Mihai Gazdag et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling

(2014) F. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ShigellaIpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages

(2014) Shiho Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG

(2014) Andrey M. Grishin et al.   STRUCTURE

Legionella pneumophilaSubversion of Host Vesicular Transport by SidC Effector Proteins

(2014) Florian A. Horenkamp et al.   TRAFFIC

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

(2014) Qing Yao et al.   PLoS Pathogens

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Xanthomonas Type III Effector XopD Desumoylates Tomato Transcription Factor SlERF4 to Suppress Ethylene Responses and Promote Pathogen Growth

(2013) Jung-Gun Kim et al.   Cell Host & Microbe

NleB, a Bacterial Effector with Glycosyltransferase Activity, Targets GAPDH Function to Inhibit NF-κB Activation

(2013) Xiaofei Gao et al.   Cell Host & Microbe

Non-canonical ubiquitylation: Mechanisms and consequences

(2013) Gary S. McDowell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Identification of the Major Ubiquitin-binding Domain of thePseudomonas aeruginosaExoU A2Phospholipase

(2013) David M. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Recognition of Ubc13 by the Shigella flexneri Effector OspI

(2013) Akira Nishide et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase

(2013) A. F. A. Keszei et al.   MOLECULAR AND CELLULAR BIOLOGY

Lack of Effect of the Salmonella Deubiquitinase SseL on the NF-κB Pathway

(2013) Francisco S. Mesquita et al.   PLoS One

The Shigella Type Three Secretion System Effector OspG Directly and Specifically Binds to Host Ubiquitin for Activation

(2013) Yan Zhou et al.   PLoS One

Shigella IpaH0722 E3 Ubiquitin Ligase Effector Targets TRAF2 to Inhibit PKC–NF-κB Activity in Invaded Epithelial Cells

(2013) Hiroshi Ashida et al.   PLoS Pathogens

Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition

(2013) Panhan Fu et al.   PLoS Pathogens

A Pathogen Type III Effector with a Novel E3 Ubiquitin Ligase Architecture

(2013) Alexander U. Singer et al.   PLoS Pathogens

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Shigella flexneriT3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-κB p65 protein

(2012) Fang Wang et al.   CELLULAR MICROBIOLOGY

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

(2012) Takahito Sanada et al.   NATURE

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions

(2012) D. Y.-w. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse ubiquitin signaling in NF-κB activation

(2012) Kazuhiro Iwai   TRENDS IN CELL BIOLOGY

The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates

(2012) Francisco S. Mesquita et al.   PLoS Pathogens

Functional Analysis of NopM, a Novel E3 Ubiquitin Ligase (NEL) Domain Effector of Rhizobium sp. Strain NGR234

(2012) Da-Wei Xin et al.   PLoS Pathogens

The Deubiquitinase Activity of the Salmonella Pathogenicity Island 2 Effector, SseL, Prevents Accumulation of Cellular Lipid Droplets

(2011) Ellen T. Arena et al.   INFECTION AND IMMUNITY

Conserved Structural Mechanisms for Autoinhibition in IpaH Ubiquitin Ligases

(2011) Yang-Chieh Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

TheXanthomonasType III Effector XopD Targets theArabidopsisTranscription Factor MYB30 to Suppress Plant Defense

(2011) Joanne Canonne et al.   PLANT CELL

The EHEC Type III Effector NleL Is an E3 Ubiquitin Ligase That Modulates Pedestal Formation

(2011) Heather Piscatelli et al.   PLoS One

The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication

(2010) M. Lomma et al.   CELLULAR MICROBIOLOGY

Destabilization of YopE by the Ubiquitin-Proteasome Pathway Fine-Tunes Yop Delivery into Host Cells and Facilitates Systemic Spread ofYersinia enterocoliticain Host Lymphoid Tissue

(2010) Kristin Gaus et al.   INFECTION AND IMMUNITY

Indispensable Role for the Eukaryotic-Like Ankyrin Domains of the Ankyrin B Effector of Legionella pneumophila within Macrophages and Amoebae

(2010) C. T. D. Price et al.   INFECTION AND IMMUNITY

E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates

(2010) A. W. Ensminger et al.   INFECTION AND IMMUNITY

The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation

(2010) Venkataramanan Soundararajan et al.   Innate Immunity

Biochemical and Structural Studies of a HECT-like Ubiquitin Ligase fromEscherichia coliO157:H7

(2010) David Yin-wei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidation by the Host Prenyltransferase Machinery Facilitates Membrane Localization ofLegionella pneumophilaEffector Proteins

(2010) Stanimir S. Ivanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector ofLegionella pneumophila

(2010) Christopher T.D. Price et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Identification of an unconventional E3 binding surface on the UbcH5   Ub conjugate recognized by a pathogenic bacterial E3 ligase.

(2010) I. Levin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases

(2010) Bin Wu et al.   PLoS Pathogens

Legionella Metaeffector Exploits Host Proteasome to Temporally Regulate Cognate Effector

(2010) Tomoko Kubori et al.   PLoS Pathogens

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Diversification of a Salmonella Virulence Protein Function by Ubiquitin-Dependent Differential Localization

(2009) Jayesh C. Patel et al.   CELL

Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane

(2009) Leigh A. Knodler et al.   CELLULAR MICROBIOLOGY

AvrPtoB Targets the LysM Receptor Kinase CERK1 to Promote Bacterial Virulence on Plants

(2009) Selena Gimenez-Ibanez et al.   CURRENT BIOLOGY

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases

(2009) C. M. Quezada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Inhibition of a Bacterial Virulence Effector Triggers Immunity to Infection

(2009) V. Ntoukakis et al.   SCIENCE

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

(2009) Christopher T. Price et al.   PLoS Pathogens

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

ChlaDub1 ofChlamydia trachomatissuppresses NF-κB activation and inhibits IκBα ubiquitination and degradation

(2008) Gaëlle Le Negrate et al.   CELLULAR MICROBIOLOGY

TheLegionella pneumophilaphosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

(2008) Curdin Ragaz et al.   CELLULAR MICROBIOLOGY

Modulation of ubiquitin dynamics and suppression of DALIS formation by theLegionella pneumophilaDot/Icm system

(2008) Stanimir S. Ivanov et al.   CELLULAR MICROBIOLOGY

Plant Pattern-Recognition Receptor FLS2 Is Directed for Degradation by the Bacterial Ubiquitin Ligase AvrPtoB

(2008) Vera Göhre et al.   CURRENT BIOLOGY

Pseudomonas syringae Effector AvrPto Blocks Innate Immunity by Targeting Receptor Kinases

(2008) Tingting Xiang et al.   CURRENT BIOLOGY

SopB promotes phosphatidylinositol 3-phosphate formation onSalmonellavacuoles by recruiting Rab5 and Vps34

(2008) Gustavo V. Mallo et al.   JOURNAL OF CELL BIOLOGY

A Dot/Icm-translocated ankyrin protein ofLegionella pneumophilais required for intracellular proliferation within human macrophages and protozoa

(2008) Souhaila Al-Khodor et al.   MOLECULAR MICROBIOLOGY

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions

(2008) Tomoko Kubori et al.   MOLECULAR MICROBIOLOGY

Structure of a Shigella effector reveals a new class of ubiquitin ligases

(2008) Yongqun Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

(2008) Alexander U Singer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY