Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1–42synaptotoxicity

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly

(2017) Tolga Soykan et al.   NEURON

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

Altered Distribution of RhoA in Alzheimer's Disease and AβPP Overexpressing Mice

(2017) Gema Huesa et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

(2016) Carlo Ballatore et al.   ACS Chemical Neuroscience

Microtubules in health and degenerative disease of the nervous system

(2016) Andrew J. Matamoros et al.   BRAIN RESEARCH BULLETIN

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease

(2016) Soumyananda Chakraborti et al.   Cytoskeleton

Stability properties of neuronal microtubules

(2016) Peter W. Baas et al.   Cytoskeleton

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Soluble Conformers of A  and Tau Alter Selective Proteins Governing Axonal Transport

(2016) M. A. Sherman et al.   JOURNAL OF NEUROSCIENCE

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells

(2016) Francesca Bartolini et al.   MOLECULAR BIOLOGY OF THE CELL

Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

(2016) Lorène Penazzi et al.   NEUROPHARMACOLOGY

Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity

(2016) Derrick P. McVicker et al.   Nature Communications

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

(2016) Mary Muhia et al.   Cell Reports

mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety

(2016) Yuichi Deguchi et al.   Cell Reports

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

(2016) Liang Wang et al.   JAMA Neurology

A dynamic formin-dependent deep F-actin network in axons

(2015) Archan Ganguly et al.   JOURNAL OF CELL BIOLOGY

Microtubule Dynamicity Is More Important than Stability in Memory Formation: an In Vivo Study

(2015) Deyhim Atarod et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules

(2015) Shusaku Uchida et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC6 and RhoA are novel players in Abeta-driven disruption of neuronal polarity

(2015) Hanako Tsushima et al.   Nature Communications

Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

(2015) Lanfranco Leo et al.   Cell Reports

Biallelic Truncating Mutations in FMN2, Encoding the Actin-Regulatory Protein Formin 2, Cause Nonsyndromic Autosomal-Recessive Intellectual Disability

(2014) Rosalind Law et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effects of α-Tubulin K40 Acetylation and Detyrosination on Kinesin-1 Motility in a Purified System

(2014) Neha Kaul et al.   BIOPHYSICAL JOURNAL

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

The A 1-42 peptide regulates microtubule stability independently of tau

(2014) B. Pianu et al.   JOURNAL OF CELL SCIENCE

A Presynaptic Role of Microtubule-Associated Protein 1/Futsch in Drosophila: Regulation of Active Zone Number and Neurotransmitter Release

(2014) S. Lepicard et al.   JOURNAL OF NEUROSCIENCE

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Activating transcription factor 4 (ATF4) modulates post-synaptic development and dendritic spine morphology

(2014) Jin Liu et al.   Frontiers in Cellular Neuroscience

Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

(2014) Shusaku Uchida et al.   Nature Communications

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

Synaptic Regulation of Microtubule Dynamics in Dendritic Spines by Calcium, F-Actin, and Drebrin

(2013) E. B. Merriam et al.   JOURNAL OF NEUROSCIENCE

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

Cross-Linking of Cell Surface Amyloid Precursor Protein Leads to Increased  -Amyloid Peptide Production in Hippocampal Neurons: Implications for Alzheimer's Disease

(2012) R. Lefort et al.   JOURNAL OF NEUROSCIENCE

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

BDNF-Induced Increase of PSD-95 in Dendritic Spines Requires Dynamic Microtubule Invasions

(2011) X. Hu et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry

(2011) L. C. Kapitein et al.   JOURNAL OF NEUROSCIENCE

Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity

(2011) Pedro J Chacon et al.   Molecular Neurodegeneration

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic Microtubules Promote Synaptic NMDA Receptor-Dependent Spine Enlargement

(2011) Elliott B. Merriam et al.   PLoS One

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid

(2011) Volker Nimmrich et al.   REVIEWS IN THE NEUROSCIENCES

Pathways linking Aβ and tau pathologies: Figure 1

(2010) Frank M. LaFerla   BIOCHEMICAL SOCIETY TRANSACTIONS

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

History-Dependent Catastrophes Regulate Axonal Microtubule Behavior

(2010) Tatiana Stepanova et al.   CURRENT BIOLOGY

The dynamic cytoskeleton: backbone of dendritic spine plasticity

(2010) Erik W Dent et al.   CURRENT OPINION IN NEUROBIOLOGY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts

(2010) H. Sudo et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice

(2010) P. Fanara et al.   NEUROSCIENCE

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons

(2010) J. Bertrand et al.   NEUROSCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

(2010) Carsten Janke et al.   TRENDS IN NEUROSCIENCES

Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules

(2009) Daniela Fischer et al.   BIOCHEMISTRY

Formins and microtubules

(2009) F. Bartolini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly

(2009) Syed A. Rizvi et al.   CHEMISTRY & BIOLOGY

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

(2009) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Motor-dependent microtubule disassembly driven by tubulin tyrosination

(2009) Leticia Peris et al.   JOURNAL OF CELL BIOLOGY

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

Unleashing formins to remodel the actin and microtubule cytoskeletons

(2009) Melissa A. Chesarone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

(2009) C. Maas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites

(2008) Peter Bieling et al.   JOURNAL OF CELL BIOLOGY

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

(2008) Francesca Bartolini et al.   JOURNAL OF CELL BIOLOGY

The microtubule-binding protein CLIP-170 coordinates mDia1 and actin reorganization during CR3-mediated phagocytosis

(2008) Elodie Lewkowicz et al.   JOURNAL OF CELL BIOLOGY

Microtubules in Dendritic Spine Development

(2008) J. Gu et al.   JOURNAL OF NEUROSCIENCE

Formin-Dependent Synaptic Growth: Evidence That Dlar Signals via Diaphanous to Modulate Synaptic Actin and Dynamic Pioneer Microtubules

(2008) C. Pawson et al.   JOURNAL OF NEUROSCIENCE

Localization of the Diaphanous-related formin Daam1 to neuronal dendrites

(2008) Steven N. Salomon et al.   NEUROSCIENCE LETTERS