Article
Behavioral Sciences
Ersin Yavas, Jeremy M. Trott, Michael S. Fanselow
Summary: The study revealed the importance of cholinergic processes within the dentate gyrus in mediating sexual dimorphism in contextual fear conditioning, with specific drug interventions able to eliminate the fear level difference between males and females. The off-target effects of CNO and the involvement of muscarinic cholinergic receptors in the dentate gyrus highlight different mechanisms influencing fear conditioning in males and females.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Ana Karla Oliveira Leite, Clarissa Penha Farias, Bianca Estefani Schmidt, Lucas Teixeira, Alessandra Schmitt Rieder, Cristiane R. G. Furini, Angela T. S. Wyse
Summary: This study investigated the effects of acute strength exercise on memory consolidation and found that exercise can promote the consolidation of weak memory. This effect is dependent on the activation of NMDA-receptors, and exercise also modulates the overexpression of BDNF and synapsin I through the activation of NMDA-receptors.
Article
Neurosciences
Lucas B. Comeras, Noa Hormer, Pradeepa Mohan Bethuraj, Ramon O. Tasan
Summary: Disproportionate and maladapted fear are key features of PTSD, and the hippocampal NPY system, released together with GABA from interneurons, plays a crucial role in modulating fear responses. Co-release of NPY in the dorsal DG affects specific aspects of fear processing, contributing to fear reduction and extinction learning.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2021)
Article
Neurosciences
Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M. A. Garcia-Perez, Pedro Bekinschtein, Noelia Weisstaub, Pablo Fuentealba
Summary: Memory systems store and discriminate representations of similar experiences through pattern separation to guide future decisions efficiently. Somatostatin cells in the dentate gyrus play a crucial role in the acquisition of contextual and spatial overlapping memories.
Article
Behavioral Sciences
Kai Wei, Yiheng Liu, Xiamin Yang, Jin Liu, Yuan Li, Meng Deng, Yingwei Wang
Summary: Sevoflurane, as a GABA subtype A receptor agonist, can induce widespread apoptosis of immature dentate granule cells in postnatal day 21 mice. The study investigated whether NKCC1-mediated GABA depolarization of neurons plays a role in sevoflurane-induced neuroapoptosis, and found that bumetanide attenuated sevoflurane-induced apoptosis. Furthermore, exposure to sevoflurane did not significantly affect motor ability or anxiety levels in mice, but impaired pattern separation ability in a cognitive test, which was mitigated by bumetanide. Overall, bumetanide shows promise in protecting against anesthesia-induced neurotoxicity.
BRAIN AND BEHAVIOR
(2022)
Review
Neurosciences
Konstanze Simbriger, Ines S. Amorim, Gilliard Lach, Kleanthi Chalkiadaki, Stella Kouloulia, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas
Summary: Contextual fear conditioning is a common behavioral paradigm used in neuroscience research to study the mechanisms of learning and memory. Using ribosome profiling, a study demonstrated that an immediate shock in male mice leads to translational and transcriptional changes in Immediate Early Genes in the dorsal hippocampus, an effect often overlooked in research.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xinhao Wang, Yize Zhao, Xiaorui Shi, Miao Gong, Ying Hao, Yaling Fu, Omar Israel Velez de-la-Paz, Xi Wang, Yuru Du, Xiangfei Guo, Li Song, Li Meng, Yuan Gao, Xi Yin, Sheng Wang, Yun Shi, Haishui Shi
Summary: This study found that the administration of exogenous SO2 derivatives has an effect on the formation of contextual fear memory, but no effect on reconsolidation and retention. This provides evidence for the development of new strategies for PTSD prevention and treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Seong-Beom Park, Heung-Yeol Lim, Eun-Young Lee, Seung-Woo Yoo, Hyun-Suk Jung, Eunsoo Lee, Woong Sun, Inah Lee
Summary: The fasciola cinereum (FC) is a subregion of the hippocampus that shows clear anatomical borders with the CA1 and receives inputs from the lateral entorhinal cortex and perirhinal cortex while projecting exclusively to the crest of the DG. Neurotoxic lesions in the FC impair visual contextual memory acquisition and place recognition in rats, suggesting a critical role in contextual pattern separation in the hippocampus.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Christine Stubbendorff, Carl W. Stevenson
Summary: Research has shown that dopamine plays a crucial role in regulating various contextual fear processes, although the related neurochemical mechanisms are still not fully understood. Understanding how dopamine regulates contextual fear can provide novel insights into the neurochemical modulation of neural circuit function underlying memory processing.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Antoine Besnard, Amar Sahay
Summary: Enhancing adult hippocampal neurogenesis through genetic means has been shown to promote contextual fear discrimination by increasing c-Fos expression in specific subfields of the hippocampus. Additionally, activation of somatostatin expressing neurons in the dorsolateral septum indicates their role in calibrating defensive behavior, providing insights into how this genetic enhancement affects hippocampal-dorsolateral septal circuits.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jiahui Yu, Toshie Naoi, Masanori Sakaguchi
Summary: Fear generalization is a symptom of anxiety-related disorders, as demonstrated in mice exposed to similar neutral contexts after fear conditioning. This study provides insight into factors influencing fear generalization and may aid future research into the pathophysiological mechanisms of anxiety-related disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Bo Lei, Bilin Kang, Wantong Lin, Haichao Chen, Yuejun Hao, Jian Ma, Songhai Shi, Yi Zhong
Summary: This study reveals the role of adult newborn granule cells (anbGCs) in the emotional state-dependent adaptability of memory retrieval. Acute social reward enhances memory retrieval by increasing engram cell reactivation, while acute social stress weakens retrieval and reduces reactivation. This bidirectional regulation is mediated by distinct populations of anbGCs, which modulate dDG activity to regulate and predict memory retrieval performance.
Article
Neurosciences
Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomita
Summary: This study characterized the transcription profile of microglia in a fear memory conditional mouse model, and found that synapse-related genes were induced while immune-related genes were reduced after fear memory consolidation. The expression of synapse-related genes reversed after fear memory extinction, but immune-related genes remained unchanged. The expression of neurotransmitter release regulators in hippocampal microglia was also found to be correlated with fear memory formation and extinction.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Ana Oliveira, Marcia Azevedo, Rafaela Seixas, Raquel Martinho, Paula Serrao, Monica Moreira-Rodrigues
Summary: Adrenaline and glucose released during stress may strengthen contextual fear memory. Glucose can enhance contextual fear memory independently of adrenaline in Ad-deficient mice, possibly through increased gene expression in the hippocampus. Additionally, adrenaline and glucose may act synergistically to strengthen contextual fear memory.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Felipe Fredes, Maria Alejandra Silva, Peter Koppensteiner, Kenta Kobayashi, Maximilian Joesch, Ryuichi Shigemoto
Summary: The study demonstrates the important role of a pathway between ventral mossy cells and dorsal granule cells in the hippocampus in the formation of novelty-induced memory, influencing the activation of dorsal granule cells through excitatory transmission; furthermore, the manipulation of ventral mossy cell activity can bidirectionally regulate the acquisition of novelty-induced contextual memory.
Review
Clinical Neurology
Shusaku Uchida, Hirotaka Yamagata, Tomoe Seki, Yoshifumi Watanabe
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2018)
Meeting Abstract
Neurosciences
Shusaku Uchida, Hirotaka Yamagata, Tomoe Seki, Ayumi Kobayashi, Kumiko Hara, Koji Matsuo, Shin Nakagawa, Yoshifumi Watanabe
BIOLOGICAL PSYCHIATRY
(2018)
Article
Psychiatry
Tomoe Seki, Hirotaka Yamagata, Shusaku Uchida, Chong Chen, Ayumi Kobayashi, Masaaki Kobayashi, Kenichiro Harada, Koji Matsuo, Yoshifumi Watanabe, Shin Nakagawa
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Article
Immunology
Shigeo Miyata, Hirotaka Yamagata, Koji Matsuo, Shusaku Uchida, Kenichiro Harada, Kazuyuki Fujihara, Yuchio Yanagawa, Yoshifumi Watanabe, Masahiko Mikuni, Shin Nakagawa, Masato Fukuda
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Chemistry, Physical
Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki
Article
Multidisciplinary Sciences
Hirotaka Yamagata, Hiroyuki Ogihara, Koji Matsuo, Shusaku Uchida, Ayumi Kobayashi, Tomoe Seki, Masaaki Kobayashi, Kenichiro Harada, Chong Chen, Shigeo Miyata, Masato Fukuda, Masahiko Mikuni, Yoshihiko Hamamoto, Yoshifumi Watanabe, Shin Nakagawa
Summary: The study identified DNA methylation markers more suitable for adult-onset depression (AOD) patients than for late-onset depression (LOD) patients. The methylation profile of AOD group was distinct and more homogeneous compared to the LOD group. Six identified methylation CpG sites were validated as potential markers for AOD, and a combination of three specific methylation markers achieved the highest accuracy.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yusuke Sakai, Haiyan Li, Hiromichi Inaba, Yuki Funayama, Erina Ishimori, Ayako Kawatake-Kuno, Hirotaka Yamagata, Tomoe Seki, Teruyuki Hobara, Shin Nakagawa, Yoshifumi Watanabe, Susumu Tomita, Toshiya Murai, Shusaku Uchida
Summary: The study explores the role of CaMKII beta in the ventral hippocampus in depression susceptibility and resilience, revealing that its modulation of TARP gamma-8 phosphorylation enhances stress resilience by increasing the expression of AMPA receptor subunit GluA1. These findings provide new insights into the molecular mechanisms underlying chronic stress-induced behavioral changes and offer strategies for preventing and treating stress-related psychiatric disorders.
Article
Multidisciplinary Sciences
Hirotaka Yamagata, Ayumi Kobayashi, Ryouichi Tsunedomi, Tomoe Seki, Masaaki Kobayashi, Kosuke Hagiwara, Chong Chen, Shusaku Uchida, Go Okada, Manabu Fuchikami, Toshiharu Kamishikiryo, Jun-ichi Iga, Shusuke Numata, Makoto Kinoshita, Takahiro A. Kato, Ryota Hashimoto, Hiroaki Nagano, Yasumasa Okamoto, Shuichi Ueno, Tetsuro Ohmori, Shin Nakagawa
Summary: This study presents a new methodology for high-quality RNA extraction from frozen whole blood samples. Thawing blood samples on aluminum blocks at room temperature can minimize RNA degradation, improve RNA yield and quality compared with thawing in a 37 degrees C water bath.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Ayako Kawatake-Kuno, Toshiya Murai, Shusaku Uchida
Summary: Major depressive disorder (MDD) is a leading cause of disability worldwide, with aberrant neuroplasticity mediated by epigenetic dysregulation playing a crucial role in its development. Sex-related differences in the pathophysiology of MDD and response to antidepressants have also been observed. Research suggests that sex-dependent epigenetic alterations may influence susceptibility to stress and depression.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Tomoe Seki, Hirotaka Yamagata, Shusaku Uchida, Ayumi Kobayashi, Yoshifumi Watanabe, Shin Nakagawa
Summary: Postpartum depression is a significant mental health issue that impacts not only mothers but also children's development, family members, and society at large. The development of an appropriate animal model to study the pathogenesis of postpartum depression is crucial. The new mouse model using a psychological stress method showed significant effects on postpartum depression-like behaviors.
SCIENTIFIC REPORTS
(2021)
Review
Behavioral Sciences
Ayako Kawatake-Kuno, Toshiya Murai, Shusaku Uchida
Summary: Major depressive disorder (MDD) is a serious disease with poorly understood mechanisms and unsatisfactory treatment advances. Ketamine's antidepressant effect is a significant discovery in psychiatric research. Evidence supports the involvement of the glutamatergic pathway in MDD pathophysiology and antidepressant effects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Neurosciences
Ileana Fuentes, Yoshikazu Morishita, Sofia Gonzalez-Salinas, Frances A. Champagne, Shusaku Uchida, Gleb P. Shumyatsky
Summary: Maternal behavior is influenced by developmental needs and environmental factors, and the maternal brain exhibits a high degree of plasticity that overlaps with mechanisms involved in memory formation. The role of activity- and experience-dependent processes in maternal behavior is still unclear, despite the identification of various molecules and intracellular processes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Margret Shirinian, Chong Chen, Shusaku Uchida, Nafisa M. Jadavji
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Hiromichi Inaba, Haiyan Li, Ayako Kawatake-Kuno, Ken-ichi Dewa, Jun Nagai, Naoya Oishi, Toshiya Murai, Shusaku Uchida
Summary: Chronic stress increases the risk of developing mood and anxiety disorders, and dysfunction of the Fos-mediated transcription network in the ACC is implicated in stress-induced social interaction deficits. Calcium and cyclic AMP pathways in the ACC modulate Fos expression and regulate stress-induced changes in social behaviors. These findings provide a potential therapeutic target for psychiatric disorders related to stressful environments.
Meeting Abstract
Neurosciences
Shusaku Uchida
NEUROPSYCHOPHARMACOLOGY
(2019)