From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform

Fibronectin-targeted drug delivery in cancer

(2016) Heena Kumra et al.   ADVANCED DRUG DELIVERY REVIEWS

A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer

(2016) Eliseos J. Mucaki et al.   BMC Medical Genomics

Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancer

(2016) Didier Meseure et al.   BRITISH JOURNAL OF CANCER

Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes

(2016) Bon Ham Yip et al.   CURRENT PHARMACEUTICAL DESIGN

Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer

(2016) Kazushi Inoue et al.   INTERNATIONAL JOURNAL OF CANCER

Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication

(2016) Lulzim Shkreta et al.   NUCLEIC ACIDS RESEARCH

hnRNP A1-mediated translational regulation of the G quadruplex-containing RON receptor tyrosine kinase mRNA linked to tumor progression

(2016) Anne Cammas et al.   Oncotarget

HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells

(2016) Rong Jia et al.   Scientific Reports

Alternative splicing as a biomarker and potential target for drug discovery

(2015) Kai-qin Le et al.   ACTA PHARMACOLOGICA SINICA

Myelodysplastic syndromes: Contemporary review and how we treat

(2015) Naseema Gangat et al.   AMERICAN JOURNAL OF HEMATOLOGY

Human DMTF1β antagonizes DMTF1α regulation of the p14ARF tumor suppressor and promotes cellular proliferation

(2015) Mario P. Tschan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

EDB Fibronectin Specific Peptide for Prostate Cancer Targeting

(2015) Zheng Han et al.   BIOCONJUGATE CHEMISTRY

hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies

(2015) Miguel Gallardo et al.   CANCER CELL

Transcription factors that interact with p53 and Mdm2

(2015) Kazushi Inoue et al.   INTERNATIONAL JOURNAL OF CANCER

DMP1β, a splice isoform of the tumour suppressorDMP1locus, induces proliferation and progression of breast cancer

(2015) Dejan Maglic et al.   JOURNAL OF PATHOLOGY

Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis

(2015) Jingwen Song et al.   MOLECULAR AND CELLULAR BIOLOGY

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

Intron retention is a widespread mechanism of tumor-suppressor inactivation

(2015) Hyunchul Jung et al.   NATURE GENETICS

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage

(2015) Daniel F. Comiskey et al.   NUCLEIC ACIDS RESEARCH

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

SRSF3 and hnRNP H1 regulate a splicing hotspot ofHER2in breast cancer cells

(2015) Hannah Gautrey et al.   RNA Biology

Regulation of alternative splicing of CD44 in cancer

(2014) Lubomir Prochazka et al.   CELLULAR SIGNALLING

Emerging Functions of SRSF1, Splicing Factor and Oncoprotein, in RNA Metabolism and Cancer

(2014) S. Das et al.   MOLECULAR CANCER RESEARCH

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

The RNAissance family: SR proteins as multifaceted regulators of gene expression

(2014) Jonathan M. Howard et al.   Wiley Interdisciplinary Reviews-RNA

Cooperation between Dmp1 Loss and Cyclin D1 Overexpression in Breast Cancer

(2013) Sinan Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8

(2013) Ha Na Jang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Alternative splicing of mutually exclusive exons—A review

(2013) Martin Pohl et al.   BIOSYSTEMS

Novel alternative splicing isoform biomarkers identification from high-throughput plasma proteomics profiling of breast cancer

(2013) Fan Zhang et al.   BMC Systems Biology

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players

(2013) Guorui Deng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heterogeneous Nuclear Ribonucleoprotein K (hnRNP-K) Promotes Tumor Metastasis by Induction of Genes Involved in Extracellular Matrix, Cell Movement, and Angiogenesis

(2013) Ran Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA catalyses nuclear pre-mRNA splicing

(2013) Sebastian M. Fica et al.   NATURE

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dmp1α Inhibits HER2/neu-Induced Mammary Tumorigenesis

(2013) Elizabeth A. Fry et al.   PLoS One

Misregulation of Pre-mRNA Alternative Splicing in Cancer

(2013) J. Zhang et al.   Cancer Discovery

Dmp1 Physically Interacts with p53 and Positively Regulates p53's Stability, Nuclear Localization, and Function

(2012) D. P. Frazier et al.   CANCER RESEARCH

BRCA2 Deep Intronic Mutation Causing Activation of a Cryptic Exon: Opening toward a New Preventive Therapeutic Strategy

(2012) O. Anczukow et al.   CLINICAL CANCER RESEARCH

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

(2012) Mo Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer

(2012) D Maglic et al.   ONCOGENE

Alternative polyadenylation: New insights from global analyses

(2012) Y. Shi   RNA

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

(2012) M Ri et al.   Blood Cancer Journal

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

(2012) Shipra Das et al.   Cell Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Carcinoembryonic antigen (CEA) and its receptor hnRNP M are mediators of metastasis and the inflammatory response in the liver

(2011) Peter Thomas et al.   CLINICAL & EXPERIMENTAL METASTASIS

Shuttling SR proteins: more than splicing factors

(2011) Laure Twyffels et al.   FEBS Journal

SRSF1 Regulates the Alternative Splicing of Caspase 9 Via A Novel Intronic Splicing Enhancer Affecting the Chemotherapeutic Sensitivity of Non-Small Cell Lung Cancer Cells

(2011) J. C. Shultz et al.   MOLECULAR CANCER RESEARCH

Unraveling the mechanism of BRCA2 in homologous recombination

(2011) William K Holloman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid-Response Splicing Reporter Screens Identify Differential Regulators of Constitutive and Alternative Splicing

(2010) I. Younis et al.   MOLECULAR AND CELLULAR BIOLOGY

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Delivering cytokines at tumor site: The immunocytokine-conjugated anti-EDB-fibronectin antibody case

(2009) Roberto Ronca et al.   IMMUNOBIOLOGY

Modification of Alternative Splicing of Mcl-1 Pre-mRNA Using Antisense Morpholino Oligonucleotides Induces Apoptosis in Basal Cell Carcinoma Cells

(2009) Jeng-Jer Shieh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

SR Proteins in Vertical Integration of Gene Expression from Transcription to RNA Processing to Translation

(2009) Xiang-Yang Zhong et al.   MOLECULAR CELL

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Alternative Splicing Markers for Breast Cancer

(2008) J. P. Venables et al.   CANCER RESEARCH

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

Alternative Splicing and Tumor Progression

(2008) Claudia Ghigna et al.   CURRENT GENOMICS

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER