RNA catalyses nuclear pre-mRNA splicing

RNAtomy of the Spliceosome’s heart

(2013) Sophie Bonnal et al.   EMBO JOURNAL

RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core

(2013) Maria Anokhina et al.   EMBO JOURNAL

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

(2013) Matthew J Schellenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualizing Group II Intron Catalysis through the Stages of Splicing

(2012) Marco Marcia et al.   CELL

Structure of the yeast U2/U6 snRNA complex

(2012) J. E. Burke et al.   RNA

Staying on message: ensuring fidelity in pre-mRNA splicing

(2012) Daniel R. Semlow et al.   TRENDS IN BIOCHEMICAL SCIENCES

Splicing of an intervening sequence by protein-free human snRNAs

(2011) Yasaman Jaladat et al.   RNA Biology

The DEAH Box ATPases Prp16 and Prp43 Cooperate to Proofread 5′ Splice Site Cleavage during Pre-mRNA Splicing

(2010) Prakash Koodathingal et al.   MOLECULAR CELL

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Identification of catalytic metal ion ligands in ribozymes

(2009) John K. Frederiksen et al.   METHODS

Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 To Facilitate the First Catalytic Reaction

(2009) Y.-F. Chiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps

(2009) M. A. Mefford et al.   RNA

Functional Identification of Ligands for a Catalytic Metal Ion in Group I Introns†

(2008) Marcello Forconi et al.   BIOCHEMISTRY

A critical assessment of the utility of protein-free splicing systems

(2008) D. J. Smith et al.   RNA

The use of simple model systems to study spliceosomal catalysis

(2008) S. Valadkhan et al.   RNA

Crystal Structure of a Self-Spliced Group II Intron

(2008) N. Toor et al.   SCIENCE