Dysregulated Collagen Homeostasis by Matrix Stiffening and TGF-β1 in Fibroblasts from Idiopathic Pulmonary Fibrosis Patients: Role of FAK/Akt

Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis

(2017) Marta Gabasa et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical regulation of cardiac fibroblast profibrotic phenotypes

(2017) Kate M. Herum et al.   MOLECULAR BIOLOGY OF THE CELL

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Elastic properties of hydrogels and decellularized tissue sections used in mechanobiology studies probed by atomic force microscopy

(2016) Alícia Giménez et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen

(2016) Yujie Zhang et al.   Scientific Reports

A spectrophotometer-based diffusivity assay reveals that diffusion hindrance of small molecules in extracellular matrix gels used in 3D cultures is dominated by viscous effects

(2014) Roland Galgoczy et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Effects of the immunosuppressant rapamycin on the expression of human α2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts

(2014) Zenshiro Tamaki et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Matrix Stiffening and β 1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer

(2014) Marta Puig et al.   MOLECULAR CANCER RESEARCH

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

FAK-Related Nonkinase Is a Multifunctional Negative Regulator of Pulmonary Fibrosis

(2013) Qiang Ding et al.   AMERICAN JOURNAL OF PATHOLOGY

Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-Induced Pulmonary Fibrosis in Mice

(2013) Katsuhiro Kinoshita et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures

(2013) Adai Colom et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Lung Myofibroblasts Are Characterized by Down-Regulated Cyclooxygenase-2 and Its Main Metabolite, Prostaglandin E2

(2013) Marta Gabasa et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin  1

(2012) H. Mori et al.   DEVELOPMENT

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation

(2012) Jessica L. Allen et al.   MOLECULAR BIOLOGY OF THE CELL

Integrin-Specific Mechanoresponses to Compression and Extension Probed by Cylindrical Flat-Ended AFM Tips in Lung Cells

(2012) Irene Acerbi et al.   PLoS One

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening

(2011) Jordi Alcaraz et al.   Integrative Biology

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts

(2010) Guo-qiang Cai et al.   EXPERIMENTAL CELL RESEARCH

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts

(2010) Laurence Goffin et al.   ARTHRITIS RESEARCH & THERAPY

SecretedVersusMembrane-anchored Collagenases

(2009) Farideh Sabeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue

(2009) M. Pinart et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Oxygen consumption of chondrocytes in agarose and collagen gels: A comparative analysis

(2008) Angela Guaccio et al.   BIOMATERIALS

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis

(2008) Annika Andersson-Sjöland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Approaching the degradome in idiopathic pulmonary fibrosis☆

(2008) A PARDO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Akt Blockade Downregulates Collagen and Upregulates MMP1 in Human Dermal Fibroblasts

(2008) Andreea M. Bujor et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Idiopathic pulmonary fibrosis

(2008) Eric B Meltzer et al.   Orphanet Journal of Rare Diseases

Matrix Elasticity, Cytoskeletal Tension, and TGF- : The Insoluble and Soluble Meet

(2008) R. G. Wells et al.   Science Signaling