Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer

The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events

(2016) Bernardo Nuche-Berenguer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

(2016) Dannel Yeo et al.   BMC CANCER

Key role of pancreatic stellate cells in pancreatic cancer

(2016) Srinivasa P. Pothula et al.   CANCER LETTERS

Interim results of a randomized phase II study of PEGPH20 added to nab-paclitaxel/gemcitabine in patients with stage IV previously untreated pancreatic cancer.

(2016) Sunil R. Hingorani et al.   JOURNAL OF CLINICAL ONCOLOGY

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis

(2016) Mustafa Suker et al.   LANCET ONCOLOGY

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

(2015) A. Pandolfi et al.   BLOOD

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

(2015) Fariborz Mortazavi et al.   BMC CANCER

Stromal biology and therapy in pancreatic cancer: a changing paradigm

(2015) Albrecht Neesse et al.   GUT

Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer

(2015) Mitesh J. Borad et al.   JOURNAL OF CLINICAL ONCOLOGY

The Role of p21-Activated Kinases in Pancreatic Cancer

(2015) Dannel Yeo et al.   PANCREAS

The role of pancreatic stellate cells in pancreatic cancer

(2015) John A.G. Moir et al.   SURGICAL ONCOLOGY-OXFORD

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

(2014) Jianjun Lei et al.   CANCER LETTERS

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

(2014) Dannel Yeo et al.   CANCER LETTERS

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies

(2014) Jonathan Haqq et al.   EUROPEAN JOURNAL OF CANCER

Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

(2014) Joshua A. McCarroll et al.   Frontiers in Physiology

FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

(2013) Silvia Licciulli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of Two Syngeneic Orthotopic Murine Models of Pancreatic Adenocarcinoma

(2013) Mehrdad Nikfarjam et al.   JOURNAL OF INVESTIGATIVE SURGERY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia Pathways and Cellular Stress Activate Pancreatic Stellate Cells: Development of an Organotypic Culture Model of Thick Slices of Normal Human Pancreas

(2013) Vinciane Rebours et al.   PLoS One

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

p21-activated kinases and gastrointestinal cancer

(2012) Hong He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model

(2012) H. Y. Chow et al.   CANCER RESEARCH

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Overcoming drug resistance in pancreatic cancer

(2011) Jiang Long et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

StellaTUM: current consensus and discussion on pancreatic stellate cell research

(2011) Mert Erkan et al.   GUT

Signal transduction in pancreatic stellate cells

(2009) Atsushi Masamune et al.   JOURNAL OF GASTROENTEROLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

(2008) Atsushi Masamune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH