Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Angiotensin II Type 1A Receptor Signaling Facilitates Tumor Metastasis Formation through P-Selectin–Mediated Interaction of Tumor Cells with Platelets and Endothelial Cells

(2012) Hideki Amano et al.   AMERICAN JOURNAL OF PATHOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms

(2012) Mariya T. Sweetwyne et al.   MATRIX BIOLOGY

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Losartan Slows Pancreatic Tumor Progression and Extends Survival of SPARC-Null Mice by Abrogating Aberrant TGFβ Activation

(2012) Shanna A. Arnold et al.   PLoS One

Angiotensin II Facilitates Breast Cancer Cell Migration and Metastasis

(2012) Sylvie Rodrigues-Ferreira et al.   PLoS One

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

(2012) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

(2011) Vikash P. Chauhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reduced Risk of Breast Cancer Recurrence in Patients Using ACE Inhibitors, ARBs, and/or Statins

(2011) Young Kwang Chae et al.   CANCER INVESTIGATION

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination

(2011) Daniel Keizman et al.   EUROPEAN JOURNAL OF CANCER

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired lymphatic contraction associated with immunosuppression

(2011) S. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

(2011) J. P. Habashi et al.   SCIENCE

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice

(2010) Chiyo Doi et al.   BMC CANCER

Inhibition of renin–angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine

(2010) Y Nakai et al.   BRITISH JOURNAL OF CANCER

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors

(2010) K. L. Cook et al.   CANCER RESEARCH

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

(2010) Walid S Kamoun et al.   NATURE METHODS

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy

(2009) Stefan Wilop et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

(2009) Benjamin J Vakoc et al.   NATURE MEDICINE

AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist

(2009) D. R. Rhodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis

(2008) Barbara Ulmasov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma

(2008) Andrew Leask   CELLULAR SIGNALLING

Perfusion CT: Noninvasive Surrogate Marker for Stratification of Pancreatic Cancer Response to Concurrent Chemo- and Radiation Therapy

(2008) Mi-Suk Park et al.   RADIOLOGY