Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes

(2015) Ruchi Singhal et al.   Oncotarget

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

(2013) Drazen B Zimonjic et al.   BMC CANCER

p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model

(2012) H. Y. Chow et al.   CANCER RESEARCH

Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling

(2012) H. Tabusa et al.   MOLECULAR CANCER RESEARCH

PAK1 Kinase Promotes Cell Motility and Invasiveness through CRK-II Serine Phosphorylation in Non-Small Cell Lung Cancer Cells

(2012) Matthew Rettig et al.   PLoS One

c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells

(2011) Fariborz Mortazavi et al.   CLINICAL & EXPERIMENTAL METASTASIS

Inhibition of Ras for cancer treatment: the search continues

(2011) Antonio T Baines et al.   Future Medicinal Chemistry

Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I

(2011) Lai N. Chan et al.   PLoS One

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

(2009) J. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells

(2008) A. S. McDaniel et al.   BLOOD

Biochemical and Structural Characterization of the Pak1-LC8 Interaction

(2008) Christine M. Lightcap et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds

(2008) Masaru Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK Is Regulated by PI3K, PIX, CDC42, and PP2Cα and Mediates Focal Adhesion Turnover in the Hyperosmotic Stress-induced p38 Pathway

(2008) Perry M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY