期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 15, 期 7, 页码 817-828出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2011.566216
关键词
drug resistance; pancreatic cancer
资金
- National Institutes of Health (NIH) [R21CA133604, R01CA138701]
- William and Ella Owens Medical Research Foundation
- National Science Foundation of China [30701007]
Areas covered: Previous studies have indicated various mechanisms of drug resistance in pancreatic cancer, including changes in individual genes or signaling pathways, the influence of the tumor microenvironment, and the presence of highly resistant stem cells. This review summarizes recent advances in the mechanisms of drug resistance in pancreatic cancer and potential strategies to overcome this. Expert opinion: Increasing drug delivery efficiency and decreasing drug resistance is the current aim in pancreatic cancer treatment, and will also benefit the treatment of other cancers. Understanding the molecular and cellular basis of drug resistance in pancreatic cancer will lead to the development of novel therapeutic strategies with the potential to sensitize pancreatic cancer to chemotherapy, and to increase the efficacy of current treatments in a wide variety of human cancers.
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