Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors

Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I

(2017) Seira Miyazaki et al.   GENES TO CELLS

Tri-directional anaphases as a novel chromosome segregation defect in human oocytes

(2017) Jenna Haverfield et al.   HUMAN REPRODUCTION

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy

(2017) Alexandra L. Nguyen et al.   MOLECULAR HUMAN REPRODUCTION

Mechanisms of Aneuploidy in Human Eggs

(2017) Alexandre Webster et al.   TRENDS IN CELL BIOLOGY

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I

(2017) Warif El Yakoubi et al.   Nature Communications

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

(2017) Ibtissem Nabti et al.   Nature Communications

Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1

(2017) Julie Lagirand-Cantaloube et al.   Scientific Reports

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte

(2016) An Tang et al.   CELL CYCLE

Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

(2016) Attila Toth et al.   CURRENT BIOLOGY

Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice

(2016) Sabrina Burkhardt et al.   CURRENT BIOLOGY

Long-Term Retention of CENP-A Nucleosomes in Mammalian Oocytes Underpins Transgenerational Inheritance of Centromere Identity

(2016) Evan M. Smoak et al.   CURRENT BIOLOGY

Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes

(2016) Rocío Gómez et al.   EMBO REPORTS

Novel mutations and structural deletions in TUBB8 : expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development

(2016) Biaobang Chen et al.   HUMAN REPRODUCTION

Ovarian ageing: the role of mitochondria in oocytes and follicles

(2016) Pascale May-Panloup et al.   HUMAN REPRODUCTION UPDATE

The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis

(2016) Chun-Jie Huang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Meiotic spindle assembly and chromosome segregation in oocytes

(2016) Isma Bennabi et al.   JOURNAL OF CELL BIOLOGY

Mutations inTUBB8cause a multiplicity of phenotypes in human oocytes and early embryos

(2016) Ruizhi Feng et al.   JOURNAL OF MEDICAL GENETICS

Mutations in TUBB8 and Human Oocyte Meiotic Arrest

(2016) Ruizhi Feng et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse

(2016) Miguel A. Brieño-Enríquez et al.   Cell Reports

Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis

(2016) Uddipta Biswas et al.   PLoS Genetics

Unique subcellular distribution of phosphorylated Plk1 (Ser137 and Thr210) in mouse oocytes during meiotic division and pPlk1Ser137involvement in spindle formation and REC8 cleavage

(2015) Juan Du et al.   CELL CYCLE

Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression

(2015) Shu-Tao Qi et al.   CELL CYCLE

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Complex elaboration: making sense of meiotic cohesin dynamics

(2015) Susannah Rankin   FEBS Journal

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

(2015) Hua Zhang et al.   HUMAN REPRODUCTION UPDATE

Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization

(2015) Giovanni Coticchio et al.   HUMAN REPRODUCTION UPDATE

Expression and characterization of three Aurora kinase C splice variants found in human oocytes

(2015) Jessica E. Fellmeth et al.   MOLECULAR HUMAN REPRODUCTION

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates

(2015) Christian S Ottolini et al.   NATURE GENETICS

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increasing Live Birth Rate by Preimplantation Genetic Screening of Pooled Polar Bodies Using Array Comparative Genomic Hybridization

(2015) Michael Feichtinger et al.   PLoS One

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

(2015) Z. Holubcova et al.   SCIENCE

Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births

(2015) Mary Herbert et al.   Cold Spring Harbor Perspectives in Biology

Multicohort analysis of the maternal age effect on recombination

(2015) Hilary C. Martin et al.   Nature Communications

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

(2015) Petros Marangos et al.   Nature Communications

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

(2015) Josie K. Collins et al.   Nature Communications

Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

(2015) Yogo Sakakibara et al.   Nature Communications

CRL4–DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation

(2015) Chao Yu et al.   Nature Communications

Escape from crossover interference increases with maternal age

(2015) Christopher L. Campbell et al.   Nature Communications

Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest

(2015) Sandra A. Touati et al.   Nature Communications

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

(2015) Agata P Zielinska et al.   eLife

Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities

(2015) Jessica Patel et al.   Biology Open

Examining Variation in Recombination Levels in the Human Female: A Test of the Production-Line Hypothesis

(2014) Ross Rowsey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice1

(2014) Meng-Wen Hu et al.   BIOLOGY OF REPRODUCTION

Kinetochore microtubule establishment is defective in oocytes from aged mice

(2014) Maria Shomper et al.   CELL CYCLE

Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice

(2014) Yan YUN et al.   CELL CYCLE

Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression

(2014) Solon Riris et al.   FERTILITY AND STERILITY

Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential

(2014) C. N. Salvaggio et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Actin-based spindle positioning: new insights from female gametes

(2014) M. Almonacid et al.   JOURNAL OF CELL SCIENCE

Shugoshins: Tension-Sensitive Pericentromeric Adaptors Safeguarding Chromosome Segregation

(2014) Adele L. Marston   MOLECULAR AND CELLULAR BIOLOGY

Meikin is a conserved regulator of meiosis-I-specific kinetochore function

(2014) Jihye Kim et al.   NATURE

An Examination of the Relationship between Hotspots and Recombination Associated with Chromosome 21 Nondisjunction

(2014) Tiffany Renee Oliver et al.   PLoS One

Age-Related Decrease of Meiotic Cohesins in Human Oocytes

(2014) Makiko Tsutsumi et al.   PLoS One

Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes

(2014) Simon I.R. Lane et al.   Nature Communications

DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation

(2014) S. F. Bakhoum et al.   Cancer Discovery

Selective Disruption of Aurora C Kinase Reveals Distinct Functions from Aurora B Kinase during Meiosis in Mouse Oocytes

(2014) Ahmed Z. Balboula et al.   PLoS Genetics

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1

(2013) Katie Howe et al.   BIOLOGY OF REPRODUCTION

Fine-scale mapping of meiotic recombination in Asians

(2013) Thomas Bleazard et al.   BMC GENETICS

Genome Analyses of Single Human Oocytes

(2013) Yu Hou et al.   CELL

Germline Energetics, Aging, and Female Infertility

(2013) Jonathan L. Tilly et al.   Cell Metabolism

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I

(2013) T. Visnes et al.   CHROMOSOMA

Spindle Assembly Checkpoint of Oocytes Depends on a Kinetochore Structure Determined by Cohesin in Meiosis I

(2013) Kikuë Tachibana-Konwalski et al.   CURRENT BIOLOGY

The origin and impact of embryonic aneuploidy

(2013) Elpida Fragouli et al.   HUMAN GENETICS

Evidence for dysregulation of genome-wide recombination in oocytes with nondisjoined chromosomes 21

(2013) C. D. Middlebrooks et al.   HUMAN MOLECULAR GENETICS

Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I

(2013) Olga Davydenko et al.   JOURNAL OF CELL BIOLOGY

Telomere lengths in human pronuclei, oocytes and spermatozoa

(2013) S. Turner et al.   MOLECULAR HUMAN REPRODUCTION

Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species

(2013) S. Ozturk et al.   MOLECULAR HUMAN REPRODUCTION

Casein Kinase 1 Alpha Regulates Chromosome Congression and Separation during Mouse Oocyte Meiotic Maturation and Early Embryo Development

(2013) Lu Wang et al.   PLoS One

Cytological Studies of Human Meiosis: Sex-Specific Differences in Recombination Originate at, or Prior to, Establishment of Double-Strand Breaks

(2013) Jennifer R. Gruhn et al.   PLoS One

Polo kinase Cdc5 is a central regulator of meiosis I

(2013) M. A. Attner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin

(2013) T. Nishiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust measurement of telomere length in single cells

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The APC/C in female mammalian meiosis I

(2013) Hayden Homer   REPRODUCTION

Age-associated telomere shortening in mouse oocytes

(2013) Tomoko Yamada-Fukunaga et al.   Reproductive Biology and Endocrinology

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase

(2013) Katarzyna Kuleszewicz et al.   Cell Division

Bod1 regulates protein phosphatase 2A at mitotic kinetochores

(2013) Iain M. Porter et al.   Nature Communications

Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior

(2013) Brenda Murdoch et al.   PLoS Genetics

Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse

(2013) Pengpeng Ma et al.   PLoS Genetics

Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

(2013) Ahmed Rattani et al.   eLife

The DNA damage response in mammalian oocytes

(2013) John Carroll et al.   Frontiers in Genetics

Chromosome cohesion decreases in human eggs with advanced maternal age

(2012) Francesca E. Duncan et al.   AGING CELL

Oocytes Progress beyond Prophase in the Presence of DNA Damage

(2012) Petros Marangos et al.   CURRENT BIOLOGY

Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes

(2012) L. Gui et al.   DEVELOPMENT

Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension

(2012) S. I. R. Lane et al.   DEVELOPMENT

Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study

(2012) Timo E. Strandberg et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation

(2012) Alan H Handyside et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis

(2012) Hong Liu et al.   NATURE CELL BIOLOGY

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension

(2012) A. Kolano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development

(2012) K. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Aging on Superovulation Efficiency, Aneuploidy Rates, and Sister Chromatid Cohesion in Mice Aged Up to 15 Months1

(2011) Julie A. Merriman et al.   BIOLOGY OF REPRODUCTION

Oocyte-Specific Differences in Cell-Cycle Control Create an Innate Susceptibility to Meiotic Errors

(2011) So Iha Nagaoka et al.   CURRENT BIOLOGY

The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes

(2011) J. E. Holt et al.   DEVELOPMENT

Mps1 at kinetochores is essential for female mouse meiosis I

(2011) K. Hached et al.   DEVELOPMENT

Repositioning of Aurora B Promoted by Chiasmata Ensures Sister Chromatid Mono-Orientation in Meiosis I

(2011) Takeshi Sakuno et al.   DEVELOPMENTAL CELL

A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development

(2011) Margarida Avo Santos et al.   HUMAN REPRODUCTION

Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment

(2011) I.M. van den Berg et al.   HUMAN REPRODUCTION

Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results

(2011) J. Geraedts et al.   HUMAN REPRODUCTION

Demographic and medical consequences of the postponement of parenthood

(2011) L. Schmidt et al.   HUMAN REPRODUCTION UPDATE

Array comparative genomic hybridisation on first polar bodies suggests that non-disjunction is not the predominant mechanism leading to aneuploidy in humans

(2011) A. S. Gabriel et al.   JOURNAL OF MEDICAL GENETICS

Novel signaling mechanisms in the ovary during oocyte maturation and ovulation

(2011) Marco Conti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy

(2011) E. Fragouli et al.   MOLECULAR HUMAN REPRODUCTION

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Protein Tyrosine Kinase Wee1B Is Essential for Metaphase II Exit in Mouse Oocytes

(2011) J. S. Oh et al.   SCIENCE

Chiasmata Promote Monopolar Attachment of Sister Chromatids and Their Co-Segregation toward the Proper Pole during Meiosis I

(2011) Yukinobu Hirose et al.   PLoS Genetics

Age-Dependent Recombination Rates in Human Pedigrees

(2011) Julie Hussin et al.   PLoS Genetics

Telomere DNA Deficiency Is Associated with Development of Human Embryonic Aneuploidy

(2011) Nathan R. Treff et al.   PLoS Genetics

Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl

(2010) Tomoko Nishiyama et al.   CELL

Casein kinase 1 is required for efficient removal of Rec8 during meiosis I

(2010) Cornelia Rumpf et al.   CELL CYCLE

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

Oocyte Cohesin Expression Restricted to Predictyate Stages Provides Full Fertility and Prevents Aneuploidy

(2010) Ekaterina Revenkova et al.   CURRENT BIOLOGY

Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2

(2010) Lisa Martine Lister et al.   CURRENT BIOLOGY

Rec8 Phosphorylation by Casein Kinase 1 and Cdc7-Dbf4 Kinase Regulates Cohesin Cleavage by Separase during Meiosis

(2010) Vittorio L. Katis et al.   DEVELOPMENTAL CELL

Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes

(2010) K. Tachibana-Konwalski et al.   GENES & DEVELOPMENT

Dynamics of cohesin proteins REC8, STAG3, SMC1  and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes

(2010) R. Garcia-Cruz et al.   HUMAN REPRODUCTION

Understanding follicle growth in vivo

(2010) O. Oktem et al.   HUMAN REPRODUCTION

Aurora-C Kinase Deficiency Causes Cytokinesis Failure in Meiosis I and Production of Large Polyploid Oocytes in Mice

(2010) Kuo-Tai Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts

(2010) S. Turner et al.   MOLECULAR HUMAN REPRODUCTION

Shugoshin–PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase

(2010) Tadashi Ishiguro et al.   NATURE CELL BIOLOGY

Human Ovarian Reserve from Conception to the Menopause

(2010) W. Hamish B. Wallace et al.   PLoS One

Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion

(2010) A. L. Lafont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes

(2010) Lin Liu et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing

(2010) Anver Kuliev et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice

(2010) Fang Jin et al.   PLoS Genetics

Cohesin: Its Roles and Mechanisms

(2009) Kim Nasmyth et al.   Annual Review of Genetics

Regulation of kinetochore–microtubule attachments by Aurora B kinase

(2009) Dan Liu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1

(2009) Francesca E. Duncan et al.   BIOLOGY OF REPRODUCTION

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

(2009) Barry E. McGuinness et al.   CURRENT BIOLOGY

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I

(2009) N. R. Kudo et al.   JOURNAL OF CELL SCIENCE

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

Kinetochore geometry defined by cohesion within the centromere

(2009) Takeshi Sakuno et al.   NATURE

Meiotic Recombination in Human Oocytes

(2009) Edith Y. Cheng et al.   PLoS Genetics

Regulation of APC/C Activators in Mitosis and Meiosis

(2008) Jillian A. Pesin et al.   Annual Review of Cell and Developmental Biology

Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway1

(2008) Andrea DiLuigi et al.   BIOLOGY OF REPRODUCTION

Age-associated increase in aneuploidy and changes in gene expression in mouse eggs

(2008) Hua Pan et al.   DEVELOPMENTAL BIOLOGY

Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice

(2008) E. Llano et al.   GENES & DEVELOPMENT

Securin regulates entry into M-phase by modulating the stability of cyclin B

(2008) Petros Marangos et al.   NATURE CELL BIOLOGY

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES

New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

(2008) Tiffany Renee Oliver et al.   PLoS Genetics

Enhanced polarizing microscopy as a new tool in aneuploidy research in oocytes

(2007) Ying Shen et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY