Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice

Kinetochore microtubule establishment is defective in oocytes from aged mice

(2014) Maria Shomper et al.   CELL CYCLE

Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes

(2014) Simon I.R. Lane et al.   Nature Communications

Spindle Assembly Checkpoint of Oocytes Depends on a Kinetochore Structure Determined by Cohesin in Meiosis I

(2013) Kikuë Tachibana-Konwalski et al.   CURRENT BIOLOGY

Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes

(2013) Y. Yun et al.   DEVELOPMENT

Molecular causes of aneuploidy in mammalian eggs

(2013) K. T. Jones et al.   DEVELOPMENT

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects

(2013) Jie Qiao et al.   MOLECULAR ASPECTS OF MEDICINE

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

(2013) Zhigang Xue et al.   NATURE

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

(2013) Philippe Collin et al.   NATURE CELL BIOLOGY

Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

(2013) Ahmed Rattani et al.   eLife

Chromosome cohesion decreases in human eggs with advanced maternal age

(2012) Francesca E. Duncan et al.   AGING CELL

Molecular origin of female meiotic aneuploidies

(2012) Alan H. Handyside   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lack of response to unaligned chromosomes in mammalian female gametes

(2012) Jaroslava Sebestova et al.   CELL CYCLE

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes

(2012) L. Gui et al.   DEVELOPMENT

Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension

(2012) S. I. R. Lane et al.   DEVELOPMENT

Age-related aneuploidy through cohesion exhaustion

(2012) Rolf Jessberger   EMBO REPORTS

Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation

(2012) Fangwei Wang et al.   JOURNAL OF CELL BIOLOGY

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

(2012) Anna De Antoni et al.   JOURNAL OF CELL BIOLOGY

APCFZR1 prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing

(2012) Janet E. Holt et al.   MOLECULAR BIOLOGY OF THE CELL

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting

(2012) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension

(2012) A. Kolano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development

(2012) K. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shugoshins: from protectors of cohesion to versatile adaptors at the centromere

(2012) Cristina Gutiérrez-Caballero et al.   TRENDS IN GENETICS

Effect of Aging on Superovulation Efficiency, Aneuploidy Rates, and Sister Chromatid Cohesion in Mice Aged Up to 15 Months1

(2011) Julie A. Merriman et al.   BIOLOGY OF REPRODUCTION

Meiotic Origins of Maternal Age-Related Aneuploidy1

(2011) Teresa Chiang et al.   BIOLOGY OF REPRODUCTION

Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes

(2011) Tomoya S. Kitajima et al.   CELL

Aurora-C kinase supports mitotic progression in the absence of Aurora-B

(2011) Scott D. Slattery et al.   CELL CYCLE

Oocyte-Specific Differences in Cell-Cycle Control Create an Innate Susceptibility to Meiotic Errors

(2011) So Iha Nagaoka et al.   CURRENT BIOLOGY

The Role of Shugoshin in Meiotic Chromosome Segregation

(2011) D. Clift et al.   CYTOGENETIC AND GENOME RESEARCH

The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes

(2011) J. E. Holt et al.   DEVELOPMENT

Mps1 at kinetochores is essential for female mouse meiosis I

(2011) K. Hached et al.   DEVELOPMENT

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development

(2011) G. Fernandez-Miranda et al.   DEVELOPMENT

Spindle assembly checkpoint and its regulators in meiosis

(2011) Shao-Chen Sun et al.   HUMAN REPRODUCTION UPDATE

The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy

(2011) E. Fragouli et al.   MOLECULAR HUMAN REPRODUCTION

Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?

(2011) Zhen-Bo Wang et al.   PHYSIOLOGY

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

(2011) K. Selesniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte

(2010) Liang Wei et al.   CELL CYCLE

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

Oocyte Cohesin Expression Restricted to Predictyate Stages Provides Full Fertility and Prevents Aneuploidy

(2010) Ekaterina Revenkova et al.   CURRENT BIOLOGY

Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2

(2010) Lisa Martine Lister et al.   CURRENT BIOLOGY

Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes

(2010) K. Tachibana-Konwalski et al.   GENES & DEVELOPMENT

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Aurora-C Kinase Deficiency Causes Cytokinesis Failure in Meiosis I and Production of Large Polyploid Oocytes in Mice

(2010) Kuo-Tai Yang et al.   MOLECULAR BIOLOGY OF THE CELL

The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint

(2010) Simon I R Lane et al.   REPRODUCTION

Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing

(2010) Anver Kuliev et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1

(2009) Francesca E. Duncan et al.   BIOLOGY OF REPRODUCTION

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

(2009) Barry E. McGuinness et al.   CURRENT BIOLOGY

Bub3 Is a Spindle Assembly Checkpoint Protein Regulating Chromosome Segregation during Mouse Oocyte Meiosis

(2009) Mo Li et al.   PLoS One

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Age-associated increase in aneuploidy and changes in gene expression in mouse eggs

(2008) Hua Pan et al.   DEVELOPMENTAL BIOLOGY

Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice

(2008) E. Llano et al.   GENES & DEVELOPMENT

Heterochromatin links to centromeric protection by recruiting shugoshin

(2008) Yuya Yamagishi et al.   NATURE