标题
HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism
作者
关键词
-
出版物
Hemodialysis International
Volume 21, Issue -, Pages S110-S124
出版商
Wiley
发表日期
2017-04-28
DOI
10.1111/hdi.12567
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia
- (2017) Harilal Patel et al. XENOBIOTICA
- A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial
- (2016) Richard A. Brigandi et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study
- (2016) Robert Provenzano et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects
- (2016) Tadao Akizawa et al. AMERICAN JOURNAL OF NEPHROLOGY
- Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension
- (2016) Andrew J. Bryant et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes
- (2016) Andres A. Urrutia et al. BLOOD
- Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE
- (2016) Zhiyu Dai et al. CIRCULATION
- Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD
- (2016) R. Provenzano et al. Clinical Journal of the American Society of Nephrology
- Inflammation regulates fibroblast growth factor 23 production
- (2016) Connor Francis et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
- (2016) Hanako Kobayashi et al. JOURNAL OF CLINICAL INVESTIGATION
- Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease
- (2016) Pablo E. Pergola et al. KIDNEY INTERNATIONAL
- Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification
- (2016) Sophie Mokas et al. KIDNEY INTERNATIONAL
- The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice
- (2016) Pinelopi P. Kapitsinou et al. MOLECULAR AND CELLULAR BIOLOGY
- SO036MOLIDUSTAT INCREASES HAEMOGLOBIN IN ERYTHROPOIESIS STIMULATING AGENTS (ESA)-NAIVE ANAEMIC PATIENTS WITH CHRONIC KIDNEY DISEASE NOT ON DIALYSIS (CKD-ND)
- (2016) Iain C. Macdougall et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- HIF2α–arginase axis is essential for the development of pulmonary hypertension
- (2016) Andrew S. Cowburn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats
- (2015) Terrance D Barrett et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects
- (2015) Katsutoshi Hara et al. Drug Metabolism and Pharmacokinetics
- Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling
- (2015) T. Souma et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia
- (2015) L. Holdstock et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients
- (2015) A. Besarab et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Anaemia in kidney disease: harnessing hypoxia responses for therapy
- (2015) Mark J. Koury et al. Nature Reviews Nephrology
- Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients
- (2015) Anatole Besarab et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- The ESA scenario gets complex: from biosimilar epoetins to activin traps
- (2014) W. Jelkmann NEPHROLOGY DIALYSIS TRANSPLANTATION
- Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects
- (2014) Ingo Flamme et al. PLoS One
- Cardiovascular Toxicity of Epoetin-Alfa in Patients with Chronic Kidney Disease
- (2013) Peter A. McCullough et al. AMERICAN JOURNAL OF NEPHROLOGY
- Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
- (2013) Gregg L. Semenza Annual Review of Pathology-Mechanisms of Disease
- IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2 mRNA translation
- (2013) N. Wilkinson et al. BLOOD
- Regulation of erythropoiesis by hypoxia-inducible factors
- (2013) Volker H. Haase BLOOD REVIEWS
- The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption
- (2013) Sheila A. Anderson et al. Cell Metabolism
- Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α
- (2013) Manik C. Ghosh et al. Cell Metabolism
- Patients with anaemia can shift from kidney to liver production of erythropoietin as shown by glycoform analysis
- (2013) Maria Lönnberg et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Mechanisms of Hypoxia Responses in Renal Tissue
- (2013) V. H. Haase JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Pulmonary Hypertension in CKD
- (2012) Davide Bolignano et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Regulation of hypoxia-inducible factor in kidney disease
- (2012) Masaomi Nangaku et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Renal cancer: Oxygen meets metabolism
- (2012) Volker H. Haase EXPERIMENTAL CELL RESEARCH
- Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
- (2012) Qingdu Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Novel links between HIFs, type 2 diabetes, and metabolic syndrome
- (2012) Christian M. Girgis et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The HIF Pathway and Erythrocytosis
- (2011) Frank S. Lee et al. Annual Review of Pathology-Mechanisms of Disease
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
- (2011) J. Schodel et al. BLOOD
- Deletion of HIF-2 in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice
- (2011) M. Mastrogiannaki et al. BLOOD
- Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
- (2011) V. R. Gordeuk et al. BLOOD
- Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation
- (2011) Federico Formenti et al. FASEB JOURNAL
- Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice
- (2011) Matthew Taylor et al. GASTROENTEROLOGY
- Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis
- (2011) M. Mastrogiannaki et al. HAEMATOLOGICA
- Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
- (2010) P. P. Kapitsinou et al. BLOOD
- The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
- (2010) Michele M. Hickey et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
- (2010) W. M. Bernhardt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Anemia management in chronic kidney disease
- (2010) Steven Fishbane et al. KIDNEY INTERNATIONAL
- Erythropoietic Response and Outcomes in Kidney Disease and Type 2 Diabetes
- (2010) Scott D. Solomon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
- (2010) Y. A. Minamishima et al. SCIENCE
- What Is So Bad About a Hemoglobin Level of 12 to 13 g/dL for Chronic Kidney Disease Patients Anyway?
- (2009) Anatole Besarab et al. ADVANCES IN CHRONIC KIDNEY DISEASE
- Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency
- (2009) Yatrik M. Shah et al. Cell Metabolism
- Hepcidin--A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease
- (2009) J. Zaritsky et al. Clinical Journal of the American Society of Nephrology
- HIF-2α, but not HIF-1α, promotes iron absorption in mice
- (2009) Maria Mastrogiannaki et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism
- (2009) E. B. Rankin et al. MOLECULAR AND CELLULAR BIOLOGY
- A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease
- (2009) Marc A. Pfeffer et al. NEW ENGLAND JOURNAL OF MEDICINE
- The microenvironment for erythropoiesis is regulated by HIF-2 through VCAM-1 in endothelial cells
- (2008) T. Yamashita et al. BLOOD
- Repression via the GATA box is essential for tissue-specific erythropoietin gene expression
- (2008) N. Obara et al. BLOOD
- Secondary analysis of the CHOIR trial epoetin-α dose and achieved hemoglobin outcomes
- (2008) Lynda A. Szczech et al. KIDNEY INTERNATIONAL
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Expanding chemical biology of 2-oxoglutarate oxygenases
- (2008) Christoph Loenarz et al. Nature Chemical Biology
- Potential mechanisms of adverse outcomes in trials of anemia correction with erythropoietin in chronic kidney disease
- (2008) N. D. Vaziri et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search