Review
Toxicology
Frank Thevenod, Timm Schreiber, Wing-Kee Lee
Summary: The kidney plays a crucial role in sensing changes in systemic oxygen tension and detoxification of transition metals. This review explores the molecular mechanisms of how these metals interact with the oxygen sensing pathway in the kidney and their implications in renal physiology, pathophysiology, and toxicology.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jingjing Duan, Zhuo Wang, Ran Duan, Chenxinhui Yang, Ruolin Zhao, Qi Feng, Yuanyuan Qin, Jingwei Jiang, Shouyong Gu, Kaiyan Lv, Libo Zhang, Bixia He, Lutz Birnbaumer, Song Yang, Zhen Chen, Yong Yang
Summary: This study found elevated levels of ACSL4 in the livers of NAFLD patients, inhibition of which can reduce lipid accumulation. Abemaciclib, a selective ACSL4 inhibitor, shows promise as a potential therapeutic approach for NAFLD.
Article
Physiology
Hanako Kobayashi, Olena Davidoff, Shiuli Pujari-Palmer, Malin Drevin, Volker H. Haase
Summary: This study aimed to investigate whether HIF-PHIs can reactivate EPO synthesis in interstitial cells that have undergone kidney fibrosis.
Article
Pharmacology & Pharmacy
Guanglei Xu, Tao Zou, Lijiao Deng, Guang Yang, Tingting Guo, Yi Wang, Chunxiao Niu, Qianqian Cheng, Xiqin Yang, Jie Dong, Jiyan Zhang
Summary: This study found that ARA290 has a beneficial effect on depression-like behavior induced by chronic stress through inhibiting inflammatory response and reducing the number of specific cells in the bone marrow and meninges. This suggests that ARA290 may be a potential drug option for treating depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lianyong Han, Verena Haefner, Youjia Yu, Bing Han, Hongyu Ren, Martin Irmler, Johannes Beckers, Qiongliang Liu, Annette Feuchtinger, Ali Oender Yildirim, Heiko Adler, Tobias Stoeger
Summary: In this study, the effects of nanoparticle exposure on lung disease development and herpesvirus reactivation were investigated. The results showed that exposure to nanoparticles can induce lung inflammation and emphysema-like injury, as well as reactivate herpesvirus in lung macrophages. In vitro experiments demonstrated that nanoparticle exposure rapidly activates specific signaling pathways and increases viral gene expression without causing an inflammatory response. Pharmacological inhibition of p38 can effectively prevent nanoparticle-induced virus reactivation. These findings highlight the crucial role of nanoparticle-triggered herpesvirus reactivation in the development of lung diseases.
Article
Multidisciplinary Sciences
Ning Jiang, Zhe Wang, Xiangying Guo, Zifu Peng, Yimin He, Qian Wang, Huaduo Wu, Yunlong Cui
Summary: Endurance exercise can significantly reduce obesity induced by high fat diet by regulating related genes and activating mitochondrial function to improve body fat index.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Pichamol Jirapinyo, Stephen D. Zucker, Christopher C. Thompson
Summary: This study aims to assess the effect of endoscopic gastric plication on hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). The results showed a significant reduction in hepatic fibrosis and improvement in other metabolic outcomes as well as weight loss in patients after 6-12 months.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V. L. Parsa, Parimal Misra
Summary: This study found that PIMT expression was upregulated in the livers of short-term fasted and obese mice. Modulating PIMT directly affected gluconeogenic gene expression and hepatic glucose output. Further investigations revealed that PKA regulated PIMT through phosphorylation and enhanced translation of TGS1 mRNA, thus promoting gluconeogenesis.
Article
Microbiology
Mehak Zahoor Khan, Vinay Kumar Nandicoori
Summary: PknG has the potential to be a promising drug target for adjunct therapy against latent TB, as its inhibition reduces mycobacterial survival in different models and enhances the bactericidal activity of frontline anti-TB drugs. Deletion of pknG significantly reduces the survival rate of Mtb during treatment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Meilin Wei, Cynthia Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, Aihua Zhao, Cheng Hu, Chengxing Shen, Weiping Jia, Ping Liu, Xiaojiao Zheng, Wei Jia
Summary: This study found that caloric restriction reduces the abundance of Parabacteroides distasonis in the gut and alters serum bile acid profile, which contributes to weight regain. Treatment with Parabacteroides distasonis or non-12 alpha-hydroxylated bile acids can ameliorate weight regain through increased thermogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Abdul Rahman Amin, Ngatiman M. M. Hairulhisyam, Raman Nur Fatin Aqilah, Mohd Manzor Nur Fariha, Beth L. L. Mallard, Fergus Shanahan, Antony M. M. Wheatley, Muhamad Marlini
Summary: The hepatic matrisome plays a role in the remodeling phase of liver regeneration, and the gut microbiota has been found to be involved in liver regeneration as well. This study investigated the effect of gut microbiota on gene expression of the hepatic matrisome during liver regeneration. The results showed that germ-free (GF) mice had impaired liver regeneration and lower matrisome gene expression compared to GF mice with reconstituted gut microbiota (XGF). These findings suggest that the interaction between gut microbiota and the matrisome may play a significant role in the regulation of hepatic remodeling during liver regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zamzam Awida, Sahar Hiram-Bab, Almog Bachar, Hussam Saed, Dan Zyc, Anton Gorodov, Nathalie Ben-Califa, Sewar Omari, Jana Omar, Liana Younis, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Ida Gluzman, Tamar Liron, Bitya Raphael-Mizrahi, Albert Kolomansky, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann
Summary: This study demonstrates that EPOR in the monocytic lineage is at least partially responsible for the effect of EPO on bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Miranda M. Carleton, Marius Locke, Michael V. Sefton
Summary: The study demonstrates that MAA-collagen hydrogel significantly enhances skeletal muscle regeneration after traumatic injury, increasing muscle fiber size and force production while reducing pro-inflammatory macrophages. The regenerative effects of the hydrogels are carrier-dependent with distinct gene expression profiles.
Article
Multidisciplinary Sciences
Dan Luo, Bin Jin, Xiangyu Zhai, Jing Li, Chuanyong Liu, Wei Guo, Jingxin Li
Summary: Recent studies have shown that oxytocin plays a crucial role in promoting liver regeneration, with a decline in oxytocin receptors in hepatocytes with age, as well as a decrease in serum oxytocin levels as individuals age. Oxytocin appears to promote liver cell regeneration more effectively in aged mice, potentially through the promotion of autophagy.
Article
Medicine, Research & Experimental
Yaoling Shu, Faizule Hassan, Michael C. Ostrowski, Kamal D. Mehta
Summary: Hepatic PKC beta deficiency slows disposal of glucose overload by suppressing glycogenesis and increasing hepatic glucose output, leading to lower plasma glucose levels and improved systemic glucose tolerance. This involves upregulating glucokinase and activating glycogen synthase to redirect more glucose-6-phosphate to glycogen synthesis.
Article
Multidisciplinary Sciences
Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin, Makoto Suematsu, Yoji Andrew Minamishima
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Koji Futatsugi, Hirobumi Tokuyama, Shinsuke Shibata, Makiko Naitoh, Takeshi Kanda, Hitoshi Minakuchi, Shintaro Yamaguchi, Koichi Hayashi, Yoji Andrew Minamishima, Motoko Yanagita, Shu Wakino, Hiroshi Itoh
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Daisuke Kikuchi, Yoji Andrew Minamishima, Koh Nakayama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Meeting Abstract
Cardiac & Cardiovascular Systems
Javid Moslehi, Yoji Andy Minamishima, Robert Padera, Ronglih Liao, William G. Kaelin
JOURNAL OF CARDIAC FAILURE
(2010)
Article
Oncology
Yan Bao, Kuniaki Mukai, Takako Hishiki, Akiko Kubo, Mitsuyo Ohmura, Yuki Sugiura, Tomomi Matsuura, Yoshiko Nagahata, Noriyo Hayakawa, Takehiro Yamamoto, Ryo Fukuda, Hideyuki Saya, Makoto Suematsu, Yoji Andrew Minamishima
MOLECULAR CANCER RESEARCH
(2013)
Article
Multidisciplinary Sciences
Wenchu Lin, Jian Cao, Jiayun Liu, Michael L. Beshiri, Yuko Fujiwara, Joshua Francis, Andrew D. Cherniack, Christoph Geisen, Lauren P. Blair, Mike R. Zou, Xiaohua Shen, Dan Kawamori, Zongzhi Liu, Chiara Grisanzio, Hideo Watanabe, Yoji Andrew Minamishima, Qing Zhang, Rohit N. Kulkarni, Sabina Signoretti, Scott J. Rodig, Roderick T. Bronson, Stuart H. Orkin, David P. Tuck, Elizaveta V. Benevolenskaya, Matthew Meyerson, William G. Kaelin, Qin Yan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Urology & Nephrology
Hiroaki Kikuchi, Emi Sasaki, Naohiro Nomura, Takayasu Mori, Yoji Andrew Minamishima, Yuki Yoshizaki, Naohiro Takahashi, Taisuke Furusho, Yohei Arai, Shintaro Mandai, Takahiro Yamashita, Fumiaki Ando, Yasuhiro Maejima, Kiyoshi Isobe, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
KIDNEY INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Binderiya Tserendavga, Noriyasu Ohshima, Chiaki Fujita, Koji Yuzawa, Mari Ohshima, Noriyuki Yanaka, Yoji Andrew Minamishima, Takashi Izumi
Summary: The study revealed that GDE7 can produce both LPA and cPA, while GDE4 only produces LPA. Both enzymes prefer 1-alkyllysophosphospholipids as substrates.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Microbiology
Hidetada Hirakawa, Ayako Takita, Yumika Sato, Suguru Hiramoto, Yusuke Hashimoto, Noriyasu Ohshima, Yoji A. Minamishima, Masami Murakami, Haruyoshi Tomita
Summary: The spread of drug-resistant bacteria is a major threat. Fosfomycin has recently gained attention for its effectiveness against drug-resistant bacteria. In this study, the researchers identified two genes, ackA and pta, that contribute to fosfomycin activity against Escherichia coli.
MICROBIOLOGY SPECTRUM
(2023)
Meeting Abstract
Oncology
Bilguun Erkhem-Ochir, Barbara Chivarina, Takehiko Yokobori, Evgenia Turtoi, Hideru Obinata, Gombodorj Navchaa, Yoji Andrew Minamishima, Toshiyuki Matsuzaki, Hiroshi Saeki, Masahiko Nishiyama, Ken Shirabe, Andrei Turtoi
Meeting Abstract
Pharmacology & Pharmacy
Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Shizuka Minamishima, Akiko Kubo, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2017)
Article
Medicine, Research & Experimental
Nobuyuki Tanaka, Takeo Kosaka, Yasumasa Miyazaki, Shuji Mikami, Naoya Niwa, Yutaro Otsuka, Yoji Andrew Minamishima, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Hisataka Sabe, Yasunori Okada, Per Uhlen, Makoto Suematsu, Mototsugu Oya
Meeting Abstract
Cardiac & Cardiovascular Systems
Steven M. Bair, Yoji A. Minamishima, Ronglih Liao, William G. Kaelin, Javid Moslehi
