Impact of protein D-containing pneumococcal conjugate vaccines on non-typeable Haemophilus influenzae acute otitis media and carriage

Efficacy of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine against acute otitis media and nasopharyngeal carriage in Panamanian children – A randomized controlled trial

(2017) Xavier Sáez-Llorens et al.   Human Vaccines & Immunotherapeutics

Impact of Widespread Introduction of Pneumococcal Conjugate Vaccines on Pneumococcal and Nonpneumococcal Otitis Media

(2016) Shalom Ben-Shimol et al.   CLINICAL INFECTIOUS DISEASES

Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease

(2016) Ron Dagan et al.   LANCET INFECTIOUS DISEASES

Effectiveness of the 10-Valent Pneumococcal NontypeableHaemophilus influenzaeProtein D–Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media—A Double-Blind Randomized Clinical Trial in Finland

(2016) Timo Vesikari et al.   Journal of the Pediatric Infectious Diseases Society

Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

(2015) Amanda Jane Leach et al.   BMC Pediatrics

Etiology and Antimicrobial Susceptibility of Middle Ear Fluid Pathogens in Costa Rican Children With Otitis Media Before and After the Introduction of the 7-Valent Pneumococcal Conjugate Vaccine in the National Immunization Program

(2015) Arturo Abdelnour et al.   MEDICINE

Decreased Incidence of Respiratory Infections in Children After Vaccination with Ten-valent Pneumococcal Vaccine

(2015) Samuel Sigurdsson et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease

(2015) Susan J. Pizzutto et al.   VACCINE

Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules

(2014) Amanda Jane Leach et al.   BMC Pediatrics

Understanding nontypeable Haemophilus influenzae and chronic obstructive pulmonary disease

(2014) Mir M. Alikhan et al.   CURRENT OPINION IN PULMONARY MEDICINE

Non-typeable Haemophilus influenzae, an under-recognised pathogen

(2014) Johan Van Eldere et al.   LANCET INFECTIOUS DISEASES

Immunogenicity, Impact on Carriage and Reactogenicity of 10-Valent Pneumococcal Non-Typeable Haemophilus influenzae Protein D Conjugate Vaccine in Kenyan Children Aged 1–4 Years: A Randomized Controlled Trial

(2014) Laura L. Hammitt et al.   PLoS One

Children with Chronic Suppurative Lung Disease Have a Reduced Capacity to Synthesize Interferon-Gamma In Vitro in Response to Non-Typeable Haemophilus influenzae

(2014) Susan J. Pizzutto et al.   PLoS One

Efficacy of Pneumococcal Nontypable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV) in Young Latin American Children: A Double-Blind Randomized Controlled Trial

(2014) Miguel W. Tregnaghi et al.   PLOS MEDICINE

Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies

(2014) Laura L Hammitt et al.   Lancet Global Health

The biofilm matrix destabilizers, EDTA and DNaseI, enhance the susceptibility of nontypeableHemophilus influenzaebiofilms to treatment with ampicillin and ciprofloxacin

(2014) Rosalia Cavaliere et al.   MicrobiologyOpen

Absence of an Important Vaccine and Diagnostic Target in Carriage- and Disease-Related Nontypeable Haemophilus influenzae

(2013) Heidi C. Smith-Vaughan et al.   Clinical and Vaccine Immunology

Evaluation of Concordance Between the Microorganisms Detected in the Nasopharynx and Middle Ear of Children With Otitis Media

(2013) Thijs M. A. van Dongen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Does a 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine prevent respiratory exacerbations in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: protocol for a randomised controlled trial

(2013) Kerry-Ann F O’Grady et al.   Trials

Acute Otitis Media Replacement and Recurrence in the Finnish Otitis Media Vaccine Trial

(2012) J. Jokinen et al.   CLINICAL INFECTIOUS DISEASES

Effects of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugate Vaccine on Nasopharyngeal Bacterial Colonization in Young Children: A Randomized Controlled Trial

(2012) M. R. van den Bergh et al.   CLINICAL INFECTIOUS DISEASES

Bactericidal antibody response against P6, protein D, and OMP26 of nontypeableHaemophilus influenzaeafter acute otitis media in otitis-prone children

(2012) M. Nadeem Khan et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Effectiveness of the ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against invasive pneumococcal disease: a cluster randomised trial

(2012) Arto A Palmu et al.   LANCET

Molecular Surveillance of True Nontypeable Haemophilus influenzae: An Evaluation of PCR Screening Assays

(2012) Michael J. Binks et al.   PLoS One

Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates

(2012) Lorenzo Monasta et al.   PLoS One

IgG Responses to Pneumococcal and Haemophilus Influenzae Protein Antigens Are Not Impaired in Children with a History of Recurrent Acute Otitis Media

(2012) Selma P. Wiertsema et al.   PLoS One

Epidemiology of acute otitis media in children of Latin America and the Caribbean: A systematic review and meta-analysis

(2011) Ariel Bardach et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media

(2011) R. Kaur et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Impact of the Heptavalent Pneumococcal Conjugate Vaccine on the Epidemiology of Acute Otitis Media Complicated by Otorrhea

(2011) Kostantinos Stamboulidis et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage

(2011) Roman Prymula et al.   VACCINE

Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non-type b strains

(2010) F. Resman et al.   CLINICAL MICROBIOLOGY AND INFECTION

Diagnosis, Microbial Epidemiology, and Antibiotic Treatment of Acute Otitis Media in Children

(2010) Tumaini R. Coker et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evidence for a non-replicative intracellular stage of nontypable Haemophilus influenzae in epithelial cells

(2010) P. Morey et al.   MICROBIOLOGY-SGM

Haemophilus influenzae and the complement system

(2010) Teresia Hallström et al.   TRENDS IN MICROBIOLOGY

Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children

(2010) Michael E. Pichichero et al.   VACCINE

Abrogation of nontypeable Haemophilus influenzae Protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media

(2010) Ryan W. Johnson et al.   VACCINE

Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention

(2009) Lauren O Bakaletz   Expert Review of Vaccines

Intercellular adhesion and biocide resistance in nontypeable Haemophilus influenzae biofilms

(2009) Era A. Izano et al.   MICROBIAL PATHOGENESIS

Immunogenicity of the 10-Valent Pneumococcal Non-typeable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV) Compared to the Licensed 7vCRM Vaccine

(2009) Timo Vesikari et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

(2009) Roman Prymula et al.   VACCINE

Nontypeable Haemophilus influenzae as a Pathogen in Children

(2008) Timothy F. Murphy et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The impact of vaccines on pneumonia: Key lessons from Haemophilus influenzae type b conjugate vaccines

(2008) Bradford D. Gessner et al.   VACCINE

Safety of the 11-valent pneumococcal vaccine conjugated to non-typeable Haemophilus influenzae-derived protein D in the first 2 years of life and immunogenicity of the co-administered hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus, Haemophilus influenzae type b and control hepatitis A vaccines

(2008) Roman Prymula et al.   VACCINE