期刊
EXPERT REVIEW OF VACCINES
卷 8, 期 8, 页码 1063-1082出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.09.63
关键词
biofilm; coinfection/superinfection; Eustachian tube; middle ear; Moraxella catarrhalis; nasopharyngeal colonization; nontypeable Haemophilus influenzae; Streptococcus pneumoniae; tubotympanum; upper respiratory tract virus
类别
资金
- GlaxoSmithKline Biologicals (Rixensart, Belgium)
There is compelling evidence that many infectious diseases of humans are caused by more than one microorganism. Multiple diverse in vitro systems have been used to study these complex diseases, and although the data generated have contributed greatly to our understanding of diseases of mixed microbial etiology, having rigorous, reproducible and relevant animal models of human diseases are essential for the development of novel methods to treat or prevent them. All animal models have inherent limitations; however, they also have important advantages over in vitro methods, including the presence of organized organ systems and an intact immune system, which promote our ability to characterize the pathogenesis of, and the immune response to, sequential or coinfecting microorganisms. For the highly prevalent pediatric disease otitis media, or middle-ear infection, the chinchilla (Chinchilla lanigera) has served as a gold-standard rodent host system in which to study this multifactorial and polymicrobial disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据