标题
Role of the Notch signaling in cholangiocarcinoma
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 21, Issue 5, Pages 471-483
出版商
Informa UK Limited
发表日期
2017-03-23
DOI
10.1080/14728222.2017.1310842
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors
- (2017) Renata Ferrarotto et al. JOURNAL OF CLINICAL ONCOLOGY
- Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398
- (2017) Jharna Datta et al. MOLECULAR CANCER THERAPEUTICS
- Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+Gastric Cancer Stem Cells
- (2017) Samarpita Barat et al. Stem Cells Translational Medicine
- Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties
- (2016) Shuichi Aoki et al. BMC CANCER
- The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
- (2016) L. Astudillo et al. CANCER RESEARCH
- Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis
- (2016) Wantae Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
- (2016) Chiara Ambrogio et al. NATURE MEDICINE
- Notch signalling in context
- (2016) Sarah J. Bray NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Anti-Tumor Effects of Second Generation β-Hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression
- (2016) Chiung-Kuei Huang et al. PLoS One
- Notch3 drives development and progression of cholangiocarcinoma
- (2016) Rachel V. Guest et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polyclonal SecondaryFGFR2Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma
- (2016) Lipika Goyal et al. Cancer Discovery
- Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans
- (2016) L Che et al. Oncogenesis
- Glycosylated Notch and Cancer
- (2016) Shanmugasundaram Pakkiriswami et al. Frontiers in Oncology
- Health-Related Quality of Life and Survival of Cholangiocarcinoma Patients in Northeastern Region of Thailand
- (2016) Somkiattiyos Woradet et al. PLoS One
- Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma
- (2016) Maiko Terada et al. Scientific Reports
- Notch signaling: An emerging therapeutic target for cancer treatment
- (2015) Xun Yuan et al. CANCER LETTERS
- miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
- (2015) J. Zhang et al. CANCER RESEARCH
- Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma
- (2015) A. Moeini et al. CLINICAL CANCER RESEARCH
- Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma
- (2015) Hajime Matsushima et al. DIGESTIVE AND LIVER DISEASE
- Differential effects of targeting Notch receptors in a mouse model of liver cancer
- (2015) Erik G. Huntzicker et al. HEPATOLOGY
- Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma
- (2015) Steven Koprowski et al. JOURNAL OF SURGICAL RESEARCH
- Differentially expressed gene profiles of intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and combined hepatocellular-cholangiocarcinoma by integrated microarray analysis
- (2015) Tong-Chun Xue et al. TUMOR BIOLOGY
- Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver
- (2015) Xiaolei Li et al. Oncotarget
- Molecular Signalling in Hepatocellular Carcinoma: Role of and Crosstalk among Wnt/β-Catenin, Sonic Hedgehog, Notch and Dickkopf-1
- (2015) Alexandros Giakoustidis et al. Canadian Journal of Gastroenterology and Hepatology
- Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups
- (2015) Michele Simbolo et al. Oncotarget
- Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver
- (2014) Sayaka Sekiya et al. AMERICAN JOURNAL OF PATHOLOGY
- Abstract P2-14-04: A Phase Ib Dose Escalation Trial of RO4929097 (a γ-secretase inhibitor) in Combination with Exemestane in Patients with ER + Metastatic Breast Cancer.
- (2014) JA Means-Powell et al. CANCER RESEARCH
- The Notch Pathway Inhibits TGF Signaling in Breast Cancer through HEYL-Mediated Crosstalk
- (2014) L. Han et al. CANCER RESEARCH
- Hippo Pathway Activity Influences Liver Cell Fate
- (2014) Dean Yimlamai et al. CELL
- Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes
- (2014) Branden D. Tarlow et al. Cell Stem Cell
- Wnt–Notch signalling crosstalk in development and disease
- (2014) Giovanna M. Collu et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer
- (2014) R. A. Previs et al. CLINICAL CANCER RESEARCH
- A cell-surface β-hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma
- (2014) Arihiro Aihara et al. HEPATOLOGY
- Emerging roles of Notch signaling in liver disease
- (2014) Fabian Geisler et al. HEPATOLOGY
- A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma
- (2014) Ana De Jesus-Acosta et al. INVESTIGATIONAL NEW DRUGS
- Therapeutic modulation of Notch signalling — are we there yet?
- (2014) Emma R. Andersson et al. NATURE REVIEWS DRUG DISCOVERY
- Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer
- (2014) Andrew T. Baker et al. Frontiers in Oncology
- The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
- (2013) Qi Zhou et al. BMC CANCER
- A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas
- (2013) Steffen Zender et al. CANCER CELL
- Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma
- (2013) Darjus Felix Tschaharganeh et al. GASTROENTEROLOGY
- Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes
- (2013) Daniela Sia et al. GASTROENTEROLOGY
- Robust cellular reprogramming occurs spontaneously during liver regeneration
- (2013) K. Yanger et al. GENES & DEVELOPMENT
- Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
- (2013) Utpal B Pajvani et al. NATURE MEDICINE
- Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies
- (2013) D Sia et al. ONCOGENE
- Notch inhibitors for cancer treatment
- (2013) Ingrid Espinoza et al. PHARMACOLOGY & THERAPEUTICS
- Targeting Notch signaling pathway in cancer: Clinical development advances and challenges
- (2013) Naoko Takebe et al. PHARMACOLOGY & THERAPEUTICS
- Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo
- (2013) Mona El Khatib et al. PLoS One
- Operative Management of Cholangiocarcinoma
- (2013) Ser Lee et al. SEMINARS IN LIVER DISEASE
- Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis
- (2013) Carola Maria Morell et al. Clinics and Research in Hepatology and Gastroenterology
- S1-5: Modulation of Cancer and Stem Cell Biomarkers by the Notch Inhibitor MK-0752 Added to Endocrine Therapy for Early Stage ER+ Breast Cancer.
- (2012) KS Albain et al. CANCER RESEARCH
- Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
- (2012) Augusto Villanueva et al. GASTROENTEROLOGY
- Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes
- (2012) Mina Komuta et al. HEPATOLOGY
- Cholangiocarcinomas can originate from hepatocytes in mice
- (2012) Biao Fan et al. JOURNAL OF CLINICAL INVESTIGATION
- Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes
- (2012) Sayaka Sekiya et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
- (2012) Anthony W. Tolcher et al. JOURNAL OF CLINICAL ONCOLOGY
- Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
- (2012) Luke Boulter et al. NATURE MEDICINE
- sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development
- (2012) Marion Delous et al. PLoS Genetics
- Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence
- (2011) K Pandya et al. BRITISH JOURNAL OF CANCER
- The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
- (2011) Simone Brabletz et al. EMBO JOURNAL
- Alagille syndrome: pathogenesis, diagnosis and management
- (2011) Peter D Turnpenny et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors
- (2011) Jesper B. Andersen et al. GASTROENTEROLOGY
- Risk factors for cholangiocarcinoma
- (2011) Gia L. Tyson et al. HEPATOLOGY
- Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment
- (2011) Ya-yong Li et al. JOURNAL OF GASTROINTESTINAL SURGERY
- Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
- (2011) Andreas Karakatsanis et al. MOLECULAR CARCINOGENESIS
- Notch post-translationally regulates β-catenin protein in stem and progenitor cells
- (2011) Chulan Kwon et al. NATURE CELL BIOLOGY
- Clinical diagnosis and staging of cholangiocarcinoma
- (2011) Boris Blechacz et al. Nature Reviews Gastroenterology & Hepatology
- Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome
- (2010) J. J. Hofmann et al. DEVELOPMENT
- Organogenesis and Development of the Liver
- (2010) Karim Si-Tayeb et al. DEVELOPMENTAL CELL
- Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors
- (2010) Kohei Yamamizu et al. JOURNAL OF CELL BIOLOGY
- Evaluation of Selective -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design
- (2010) P. Wei et al. MOLECULAR CANCER THERAPEUTICS
- Therapeutic antibody targeting of individual Notch receptors
- (2010) Yan Wu et al. NATURE
- Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors
- (2010) Miguel Aste-Amézaga et al. PLoS One
- The Multiple Facets of Ubiquitination in the Regulation of Notch Signaling Pathway
- (2010) Stéphanie Le Bras et al. TRAFFIC
- Intrahepatic Cholangiocarcinoma
- (2009) Itaru Endo et al. ANNALS OF SURGERY
- The Prognosis and Survival Outcome of Intrahepatic Cholangiocarcinoma Following Surgical Resection: Association of Lymph Node Metastasis and Lymph Node Dissection with Survival
- (2009) Sae-Byeol Choi et al. ANNALS OF SURGICAL ONCOLOGY
- Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia
- (2009) J Tammam et al. BRITISH JOURNAL OF PHARMACOLOGY
- Notch signaling controls liver development by regulating biliary differentiation
- (2009) Y. Zong et al. DEVELOPMENT
- Notch Signaling: The Core Pathway and Its Posttranslational Regulation
- (2009) Mark E. Fortini DEVELOPMENTAL CELL
- Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications
- (2009) Ji-Liang Li Frontiers in Bioscience-Landmark
- Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies
- (2009) Frédéric P. Lemaigre GASTROENTEROLOGY
- Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice
- (2009) Jan S. Tchorz et al. HEPATOLOGY
- Direct inhibition of the NOTCH transcription factor complex
- (2009) Raymond E. Moellering et al. NATURE
- Substrate specificity of γ-secretase and other intramembrane proteases
- (2008) A. J. Beel et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
- (2008) I. Imayoshi et al. DEVELOPMENT
- Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment
- (2008) Boris Blechacz et al. HEPATOLOGY
- ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitor
- (2008) C Osipo et al. ONCOGENE
- Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma
- (2008) S.A. Khan et al. HPB
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