Analysis of centrosome and DNA damage response in PLK4 associated Seckel syndrome

Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain

(2016) Louis-Jan Pilaz et al.   NEURON

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

Mutations inCDK5RAP2cause Seckel syndrome

(2015) Gökhan Yigit et al.   Molecular Genetics & Genomic Medicine

Genomic analysis of primordial dwarfism reveals novel disease genes

(2014) R. Shaheen et al.   GENOME RESEARCH

Mutation inPLK4, encoding a master regulator of centriole formation, defines a novel locus for primordial dwarfism

(2014) Ranad Shaheen et al.   JOURNAL OF MEDICAL GENETICS

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

(2014) Carol-Anne Martin et al.   NATURE GENETICS

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death

(2013) Christopher J Del Nagro et al.   CELL CYCLE

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

(2013) Joo-Hee Sir et al.   JOURNAL OF CELL BIOLOGY

Primary Microcephaly, Impaired DNA Replication, and Genomic Instability Caused by Compound HeterozygousATRMutations

(2012) Houda Mokrani-Benhelli et al.   HUMAN MUTATION

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?

(2012) Anna Noatynska et al.   JOURNAL OF CELL BIOLOGY

Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein

(2012) Andrew Dauber et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

(2012) Tomoo Ogi et al.   PLoS Genetics

Polo-like kinase 4 phosphorylates Chk2

(2011) Steve Petrinac et al.   CELL CYCLE

Mechanisms and pathways of growth failure in primordial dwarfism

(2011) A. Klingseisen et al.   GENES & DEVELOPMENT

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

CtIP Mutations Cause Seckel and Jawad Syndromes

(2011) Per Qvist et al.   PLoS Genetics

Human Plk4 phosphorylates Cdc25C

(2010) Sepal Bonni et al.   CELL CYCLE

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G2 checkpoint arrest

(2010) Angela Poehlmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Novel CENPJ mutation causes Seckel syndrome

(2010) M. S. Al-Dosari et al.   JOURNAL OF MEDICAL GENETICS

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

(2010) Ersan Kalay et al.   NATURE GENETICS

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication

(2009) James E. Sillibourne et al.   MOLECULAR BIOLOGY OF THE CELL

Ab ovo or de novo? Mechanisms of centriole duplication

(2009) Jadranka Loncarek et al.   MOLECULES AND CELLS

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH