CHK2 kinase in the DNA damage response and beyond

Chk2 Regulates Cell Cycle Progression during Mouse Oocyte Maturation and Early Embryo Development

(2014) Xiao-Xin Dai et al.   MOLECULES AND CELLS

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover

(2013) M Bohgaki et al.   CELL DEATH AND DIFFERENTIATION

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Structure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapies

(2013) Thomas P Matthews et al.   Expert Opinion on Drug Discovery

Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro

(2013) Jhoana Mendoza et al.   JOURNAL OF PROTEOME RESEARCH

The DNA damage response during mitosis

(2013) Anne Margriet Heijink et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress

(2013) Soo-Youn Choi et al.   NUCLEIC ACIDS RESEARCH

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

The Heterochromatic Barrier to DNA Double Strand Break Repair: How to Get the Entry Visa

(2012) Aaron A. Goodarzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

(2012) Chen Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-associated Box (KRAB)-associated Co-repressor (KAP-1) Ser-473 Phosphorylation Regulates Heterochromatin Protein 1β (HP1-β) Mobilization and DNA Repair in Heterochromatin

(2012) Emma Bolderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA viruses and the cellular DNA-damage response

(2012) A. S. Turnell et al.   JOURNAL OF GENERAL VIROLOGY

REGγ/PA28γ proteasome activator interacts with PML and Chk2 and affects PML nuclear bodies number

(2011) Laura Zannini et al.   CELL CYCLE

Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage

(2011) Alyson K. Freeman et al.   CELL CYCLE

A novel role for Chk2 after DNA damage in mitosis?

(2011) Ailine Stolz et al.   CELL CYCLE

Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation

(2011) Jae-Seok Roe et al.   CELL CYCLE

Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation

(2011) Kiyoshi Masuda et al.   EMBO JOURNAL

Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells

(2011) Byong Hoon Yoo et al.   INTERNATIONAL JOURNAL OF CANCER

Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome

(2011) Anne W. Tann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Anticancer therapy with checkpoint inhibitors: what, where and when?

(2011) Michelle D. Garrett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Loss of the tumour-suppressor genesCHK2andBRCA1results in chromosomal instability

(2010) Ailine Stolz et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage

(2010) Luigi Carlessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inactivation of DNA-Dependent Protein Kinase Leads to Spindle Disruption and Mitotic Catastrophe with Attenuated Checkpoint Protein 2 Phosphorylation in Response to DNA Damage

(2010) Zeng-Fu Shang et al.   CANCER RESEARCH

Regulation of the female mouse germ cell cycle during entry into meiosis

(2010) Denise C. Miles et al.   CELL CYCLE

Mechanism of p53 stabilization by ATM after DNA damage

(2010) Qian Cheng et al.   CELL CYCLE

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

Assembly and function of DNA double-strand break repair foci in mammalian cells

(2010) Simon Bekker-Jensen et al.   DNA REPAIR

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

(2010) Hiroyuki Niida et al.   EMBO JOURNAL

Circadian clock control of the cellular response to DNA damage

(2010) Aziz Sancar et al.   FEBS LETTERS

Per3, a circadian gene, is required for Chk2 activation in human cells

(2010) Jun-Sub Im et al.   FEBS LETTERS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity

(2010) Xin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

(2010) S. Mehdi Belgnaoui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage

(2010) N. Okada et al.   JOURNAL OF CELL SCIENCE

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Regulation of Epstein-Barr Virus Origin of Plasmid Replication (OriP) by the S-Phase Checkpoint Kinase Chk2

(2010) J. Zhou et al.   JOURNAL OF VIROLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

In Brief

(2010)   NATURE REVIEWS GENETICS

DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells

(2010) Olga Momcilovic et al.   PLoS One

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

(2010) Marcel A. T. M. van Vugt et al.   PLOS BIOLOGY

Cellular senescence: Its role in tumor suppression and aging

(2009) Naoko Ohtani et al.   CANCER SCIENCE

Senescence: an antiviral defense that is tumor suppressive?

(2009) R. R. Reddel   CARCINOGENESIS

The Shelterin Protein TRF2 Inhibits Chk2 Activity at Telomeres in the Absence of DNA Damage

(2009) Giacomo Buscemi et al.   CURRENT BIOLOGY

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Mitochondrial DNA Damage Initiates a Cell Cycle Arrest by a Chk2-associated Mechanism in Mammalian Cells

(2009) Christopher A. Koczor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian TIMELESS Is Required for ATM-dependent CHK2 Activation and G2/M Checkpoint Control

(2009) Xiaoming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells

(2009) W.-J. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1

(2009) Y-H Yeh et al.   ONCOGENE

Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias

(2009) E. M. Bahassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

(2009) Cary A. Moody et al.   PLoS Pathogens

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

ATM and Chk2 kinase target the p53 cofactor Strap

(2008) Cassandra J Adams et al.   EMBO REPORTS

HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase

(2008) Sarah S. Durkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379

(2008) C. M. Lovly et al.   MOLECULAR AND CELLULAR BIOLOGY

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

(2008) E M Bahassi et al.   ONCOGENE