Mitotic spindle (DIS)orientation and DISease: Cause or consequence?

GPSM2 Mutations Cause the Brain Malformations and Hearing Loss in Chudley-McCullough Syndrome

(2012) Dan Doherty et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Deconstructing the centriole: structure and number control

(2012) Daniela A Brito et al.   CURRENT OPINION IN CELL BIOLOGY

An oblique view on the role of spindle orientation in vertebrate neurogenesis

(2012) Elise Peyre et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Control of asymmetric cell division of mammalian neural progenitors

(2012) Atsunori Shitamukai et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The tumor suppressorApccontrols planar cell polarities central to gut homeostasis

(2012) Julien Bellis et al.   JOURNAL OF CELL BIOLOGY

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

(2012) M. A. Bogoyevitch et al.   JOURNAL OF CELL SCIENCE

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension

(2012) A. Kolano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

The Essential Role of Centrosomal NDE1 in Human Cerebral Cortex Neurogenesis

(2011) Mehmet Bakircioglu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly

(2011) Fowzan S. Alkuraya et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors

(2011) Sista Sugiarto et al.   CANCER CELL

Cep63 Recruits Cdk1 to the Centrosome: Implications for Regulation of Mitotic Entry, Centrosome Amplification, and Genome Maintenance

(2011) H. Loffler et al.   CANCER RESEARCH

Oriented cell division in vertebrate embryogenesis

(2011) I Castanon et al.   CURRENT OPINION IN CELL BIOLOGY

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development

(2011) Xavier Morin et al.   DEVELOPMENTAL CELL

An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts

(2011) Cheng Wang et al.   DEVELOPMENTAL CELL

Mitotic spindle: Focus on the function of huntingtin

(2011) Juliette D. Godin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitotic spindle misorientation in cancer - out of alignment and into the fire

(2011) J. C. Pease et al.   JOURNAL OF CELL SCIENCE

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

(2011) D. Kitagawa et al.   JOURNAL OF CELL SCIENCE

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

(2011) David P Minde et al.   Molecular Cancer

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

(2011) Benjamin Beck et al.   NATURE

The cilia protein IFT88 is required for spindle orientation in mitosis

(2011) Benedicte Delaval et al.   NATURE CELL BIOLOGY

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway

(2011) Ralph Gruber et al.   NATURE CELL BIOLOGY

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

Mouse Inscuteable Induces Apical-Basal Spindle Orientation to Facilitate Intermediate Progenitor Generation in the Developing Neocortex

(2011) Maria Pia Postiglione et al.   NEURON

Complex cellular functions of the von Hippel–Lindau tumor suppressor gene: insights from model organisms

(2011) T Hsu   ONCOGENE

Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis

(2011) L. Capalbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

(2011) Timothy L. Megraw et al.   TRENDS IN CELL BIOLOGY

Centrosomes and cilia in human disease

(2011) Mónica Bettencourt-Dias et al.   TRENDS IN GENETICS

Mutations in Centrosomal Protein CEP152 in Primary Microcephaly Families Linked to MCPH4

(2010) Duane L. Guernsey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole Exome Sequencing and Homozygosity Mapping Identify Mutation in the Cell Polarity Protein GPSM2 as the Cause of Nonsyndromic Hearing Loss DFNB82

(2010) Tom Walsh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis

(2010) Julie Higgins et al.   BMC CELL BIOLOGY

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue

(2010) Aaron J. Quyn et al.   Cell Stem Cell

Neural stem cells: the need for a proper orientation

(2010) Bart Lesage et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability

(2010) S. Duchi et al.   DEVELOPMENT

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

(2010) S. B. Lizarraga et al.   DEVELOPMENT

LGN regulates mitotic spindle orientation during epithelial morphogenesis

(2010) Zhen Zheng et al.   JOURNAL OF CELL BIOLOGY

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response

(2010) Alexis R. Barr et al.   JOURNAL OF CELL BIOLOGY

Tumor-Host Interactions: A Far-Reaching Relationship

(2010) Sandra S. McAllister et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel CENPJ mutation causes Seckel syndrome

(2010) M. S. Al-Dosari et al.   JOURNAL OF MEDICAL GENETICS

Novel Embryonic Neuronal Migration and Proliferation Defects in Dcx Mutant Mice Are Exacerbated by Lis1 Reduction

(2010) T. Pramparo et al.   JOURNAL OF NEUROSCIENCE

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

(2010) Ersan Kalay et al.   NATURE GENETICS

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

The exon junction complex component Magoh controls brain size by regulating neural stem cell division

(2010) Debra L Silver et al.   NATURE NEUROSCIENCE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

(2010) Juliette D. Godin et al.   NEURON

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

(2010) J. N. Pulvers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lissencephaly: Mechanistic insights from animal models and potential therapeutic strategies

(2010) Anthony Wynshaw-Boris et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NuMA after 30 years: the matrix revisited

(2010) Andreea E. Radulescu et al.   TRENDS IN CELL BIOLOGY

Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly

(2009) Arun Kumar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration

(2009) Heidi N. Fridolfsson et al.   DEVELOPMENTAL BIOLOGY

The role of aneuploidy in promoting and suppressing tumors: Figure 1.

(2009) Beth A.A. Weaver et al.   JOURNAL OF CELL BIOLOGY

Roles of the Drosophila NudE protein in kinetochore function and centrosome migration

(2009) A. Wainman et al.   JOURNAL OF CELL SCIENCE

Spindle misorientation in tumors fromAPCmin/+mice

(2009) Elizabeth S. Fleming et al.   MOLECULAR CARCINOGENESIS

NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα

(2009) Monique van der Voet et al.   NATURE CELL BIOLOGY

VHL loss causes spindle misorientation and chromosome instability

(2009) Claudio R. Thoma et al.   NATURE CELL BIOLOGY

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

(2009) Eloise Smith et al.   NATURE CELL BIOLOGY

Spindle orientation during asymmetric cell division

(2009) Karsten H. Siller et al.   NATURE CELL BIOLOGY

Primary microcephaly: do all roads lead to Rome?

(2009) Gemma K. Thornton et al.   TRENDS IN GENETICS

Neuroepithelial Stem Cell Proliferation Requires LIS1 for Precise Spindle Orientation and Symmetric Division

(2008) Jessica Yingling et al.   CELL

ASPM Is a Novel Marker for Vascular Invasion, Early Recurrence, and Poor Prognosis of Hepatocellular Carcinoma

(2008) S.-Y. Lin et al.   CLINICAL CANCER RESEARCH

Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not Due to Genome Instability

(2008) Elisabeth Castellanos et al.   CURRENT BIOLOGY

Cell regulation by the Apc protein

(2008) Brooke M McCartney et al.   CURRENT OPINION IN CELL BIOLOGY

Structural insights into the exon junction complex

(2008) Hervé Le Hir et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts

(2008) Karsten H. Siller et al.   DEVELOPMENTAL BIOLOGY

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

(2008) Ian J Frew et al.   EMBO JOURNAL

Cytokinesis of neuroepithelial cells can divide their basal process before anaphase

(2008) Yoichi Kosodo et al.   EMBO JOURNAL

Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth, and axon targeting?

(2008) Nasser M. Rusan et al.   JOURNAL OF CELL BIOLOGY

Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis

(2008) Stephen C. Noctor et al.   JOURNAL OF COMPARATIVE NEUROLOGY