Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling

(2015) Carlos Sacristan et al.   TRENDS IN CELL BIOLOGY

Drugging MYCN through an Allosteric Transition in Aurora Kinase A

(2014) William Clay Gustafson et al.   CANCER CELL

Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression

(2014) Zhaoqing Wang et al.   DEVELOPMENTAL CELL

Aurora kinase A mediates c-Myc's oncogenic effects in hepatocellular carcinoma

(2014) Longfeng Lu et al.   MOLECULAR CARCINOGENESIS

Cell cycle-dependent regulation of mitochondrial preprotein translocase

(2014) A. B. Harbauer et al.   SCIENCE

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe

(2014) M Cornago et al.   Cell Death & Disease

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

(2014) Daniela Annibali et al.   Nature Communications

Stressing Mitosis to Death

(2014) Andrew Burgess et al.   Frontiers in Oncology

Prometaphase arrest-dependent phosphorylation of Bcl-2 and Bim reduces the association of Bcl-2 with Bak or Bim, provoking Bak activation and mitochondrial apoptosis in nocodazole-treated Jurkat T cells

(2013) Cho Rong Han et al.   APOPTOSIS

Identification of a mitotic death signature in cancer cell lines

(2013) Nandini Sakurikar et al.   CANCER LETTERS

Characterization of novel MPS1 inhibitors with preclinical anticancer activity

(2013) M Jemaà et al.   CELL DEATH AND DIFFERENTIATION

Mitosis as an anti-cancer drug target

(2013) Anna-Leena Salmela et al.   CHROMOSOMA

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Mitosis-targeting therapies: a troubleshooting guide

(2013) Elena Doménech et al.   CURRENT OPINION IN PHARMACOLOGY

Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer

(2013) Robert Jones et al.   INVESTIGATIONAL NEW DRUGS

Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome

(2013) Ivana Gojo et al.   INVESTIGATIONAL NEW DRUGS

Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs

(2013) Bakhos A. Tannous et al.   JNCI-Journal of the National Cancer Institute

Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS1 Kinase Inhibitor NMS-P715

(2013) R. B. Slee et al.   MOLECULAR CANCER THERAPEUTICS

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor

(2013) Anna V. Miller et al.   PLoS One

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death

(2013) D S O'Donovan et al.   Cell Death & Disease

Mitotic catastrophe and cell death induced by depletion of centrosomal proteins

(2013) M Kimura et al.   Cell Death & Disease

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Cytokinesis in Animal Cells

(2012) Rebecca A. Green et al.   Annual Review of Cell and Developmental Biology

A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer

(2012) Cynthia X. Ma et al.   BREAST CANCER RESEARCH AND TREATMENT

Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells

(2012) Lei Lv et al.   CELL CYCLE

Killing cells by targeting mitosis

(2012) E Manchado et al.   CELL DEATH AND DIFFERENTIATION

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale

(2012) E. Komlodi-Pasztor et al.   CLINICAL CANCER RESEARCH

Microtubule catastrophe and rescue

(2012) Melissa K Gardner et al.   CURRENT OPINION IN CELL BIOLOGY

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Up-regulation of Pro-apoptotic Protein Bim and Down-regulation of Anti-apoptotic Protein Mcl-1 Cooperatively Mediate Enhanced Tumor Cell Death Induced by the Combination of ERK Kinase (MEK) Inhibitor and Microtubule Inhibitor

(2012) Takumi Kawabata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models

(2012) Cynthia X. Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming

(2012) Gaoyang Liang et al.   NATURE CELL BIOLOGY

Causes and consequences of aneuploidy in cancer

(2012) David J. Gordon et al.   NATURE REVIEWS GENETICS

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Central roles of apoptotic proteins in mitochondrial function

(2012) S M Kilbride et al.   ONCOGENE

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach

(2012) V Pannu et al.   Cell Death & Disease

Effects of the Polo-like-kinase-1-inhibitor BI2536 in squamous cell carcinoma cell lines of the head and neck

(2012) JENS WAGENBLAST et al.   Oncology Letters

Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer

(2011) Henry L. Gomez et al.   ANTI-CANCER DRUGS

A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias

(2011) Hanna Jean Khoury et al.   CANCER

First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer

(2011) Vincent Chung et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL

(2011) J. Shi et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cyclin B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis

(2011) Seán Mac Fhearraigh et al.   CELL CYCLE

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL

(2011) Rebecca Gilley et al.   CELLULAR SIGNALLING

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe

(2011) P. C. De Witt Hamer et al.   CLINICAL CANCER RESEARCH

Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis

(2011) Gabriela Imreh et al.   JOURNAL OF CELL SCIENCE

Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells

(2011) Kyunghee Lee et al.   MOLECULAR BIOLOGY OF THE CELL

The proliferation rate paradox in antimitotic chemotherapy

(2011) Timothy J. Mitchison   MOLECULAR BIOLOGY OF THE CELL

Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells

(2011) M. Chircop et al.   MOLECULAR CANCER THERAPEUTICS

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo

(2011) G Högnäs et al.   ONCOGENE

Physiological Relevance of Cell Cycle Kinases

(2011) Marcos Malumbres   PHYSIOLOGICAL REVIEWS

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells

(2010) Choon-Kee Lee et al.   CANCER LETTERS

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

(2010) R. Colombo et al.   CANCER RESEARCH

Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells

(2010) O Kutuk et al.   CELL DEATH AND DIFFERENTIATION

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors

(2010) Howard A. Burris et al.   INVESTIGATIONAL NEW DRUGS

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity

(2010) Y. Matthess et al.   MOLECULAR AND CELLULAR BIOLOGY

Mcl-1 Stability Determines Mitotic Cell Fate of Human Multiple Myeloma Tumor Cells Treated with the Kinesin Spindle Protein Inhibitor ARRY-520

(2010) B. J. Tunquist et al.   MOLECULAR CANCER THERAPEUTICS

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

(2010) Xiangping Qian et al.   ACS Medicinal Chemistry Letters

Kinesin motor proteins as targets for cancer therapy

(2009) Dennis Huszar et al.   CANCER AND METASTASIS REVIEWS

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

(2009) Alexander E Kelly et al.   CURRENT OPINION IN CELL BIOLOGY

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2

(2009) Joshua L Andersen et al.   EMBO JOURNAL

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit

(2009) M. E. Bekier et al.   MOLECULAR CANCER THERAPEUTICS

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

(2009) F. Herzog et al.   SCIENCE

An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner

(2008) Eun Joo Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance

(2008) Meenakshi Upreti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

(2008) Helfrid Hochegger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

(2007) T. Boveri   JOURNAL OF CELL SCIENCE