Global position paper on cardiovascular regenerative medicine

The electrophysiological development of cardiomyocytes

(2016) Jie Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

In vitro cardiac tissue models: Current status and future prospects

(2016) Anurag Mathur et al.   ADVANCED DRUG DELIVERY REVIEWS

Heart regeneration

(2016) Kaja Breckwoldt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts

(2016) Elena Garreta et al.   BIOMATERIALS

Empowering Adult Stem Cells for Myocardial Regeneration V2.0

(2016) Kathleen M. Broughton et al.   CIRCULATION RESEARCH

Effect of Bone Marrow–Derived Mononuclear Cell Treatment, Early or Late After Acute Myocardial InfarctionNovelty and Significance

(2016) Daniel Sürder et al.   CIRCULATION RESEARCH

Cardiac Stem Cell Treatment in Myocardial InfarctionNovelty and Significance

(2016) Peter Paul Zwetsloot et al.   CIRCULATION RESEARCH

Reprogramming ageing and longevity genes restores paracrine angiogenic properties of early outgrowth cells

(2016) Francesco Paneni et al.   EUROPEAN HEART JOURNAL

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

(2016) Rosalinda Madonna et al.   EUROPEAN HEART JOURNAL

Decellularized aortic homografts for aortic valve and aorta ascendens replacement

(2016) Igor Tudorache et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Clinical development plan for regenerative therapy in heart failure

(2016) Andre Terzic et al.   EUROPEAN JOURNAL OF HEART FAILURE

Decellularized Scaffold Hydrogel Materials for MI Treatment

(2016) Kevin D. Costa   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

(2016) Barry Greenberg et al.   LANCET

Acellular human heart matrix: A critical step toward whole heart grafts

(2015) Pedro L. Sánchez et al.   BIOMATERIALS

Bioprinting a cardiac valve

(2015) Soumen Jana et al.   BIOTECHNOLOGY ADVANCES

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Cell Therapy For Patients With Acute Myocardial Infarction: ACCRUEd Evidence to Date

(2015) J. C. Kovacic et al.   CIRCULATION RESEARCH

Direct Cardiac Reprogramming: Progress and Challenges in Basic Biology and Clinical Applications

(2015) T. Sadahiro et al.   CIRCULATION RESEARCH

Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in Patients With Acute Myocardial Infarction Based on Individual Patient Data

(2015) M. Gyongyosi et al.   CIRCULATION RESEARCH

Bioengineering Human Myocardium on Native Extracellular MatrixNovelty and Significance

(2015) Jacques P. Guyette et al.   CIRCULATION RESEARCH

Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial

(2015) Eugene S. Chung et al.   EUROPEAN HEART JOURNAL

Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial)

(2015) Anders Bruun Mathiasen et al.   EUROPEAN HEART JOURNAL

A randomized double-blind control study of early intra-coronary autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial

(2015) Fizzah Choudry et al.   EUROPEAN HEART JOURNAL

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report: Figure 1

(2015) Philippe Menasché et al.   EUROPEAN HEART JOURNAL

Hurdles to clinical translation of human induced pluripotent stem cells

(2015) Evgenios Neofytou et al.   JOURNAL OF CLINICAL INVESTIGATION

Interacting Resident Epicardium-Derived Fibroblasts and Recruited Bone Marrow Cells Form Myocardial Infarction Scar

(2015) Adrián Ruiz-Villalba et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of Different Bone Marrow–Derived Stem Cell Approaches in Reperfused STEMI

(2015) J. Alberto San Roman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A review of: Application of synthetic scaffold in tissue engineering heart valves

(2015) Ehsan Fallahiarezoudar et al.   Materials Science & Engineering C-Materials for Biological Applications

An alternative pluripotent state confers interspecies chimaeric competency

(2015) Jun Wu et al.   NATURE

Exosomes and exosomal miRNAs in cardiovascular protection and repair

(2015) Costanza Emanueli et al.   VASCULAR PHARMACOLOGY

Endpoints in stem cell trials in ischemic heart failure

(2015) Marko Banovic et al.   Stem Cell Research & Therapy

State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews

(2015) Mariangela Peruzzi et al.   Biomed Research International

Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial

(2014) Emerson C. Perin et al.   AMERICAN HEART JOURNAL

Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial

(2014) B. Hibbert et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

Intracoronary Infusion of Encapsulated Glucagon-Like Peptide-1–Eluting Mesenchymal Stem Cells Preserves Left Ventricular Function in a Porcine Model of Acute Myocardial Infarction

(2014) Renate de Jong et al.   Circulation-Cardiovascular Interventions

Autologous CD133+ bone marrow cells and bypass grafting for regeneration of ischaemic myocardium: the Cardio133 trial

(2014) B. A. Nasseri et al.   EUROPEAN HEART JOURNAL

All preclinical trials should be registered in advance in an online registry

(2014) Sanne J. Jansen of Lorkeers et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A Randomized, Open-Label, Multicenter Trial for the Safety and Efficacy of Adult Mesenchymal Stem Cells after Acute Myocardial Infarction

(2014) Jun-Won Lee et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

Safety and feasibility of intramyocardial versus intracoronary delivery of autologous cell therapy in advanced heart failure: the REGENERATE-IHD pilot study

(2014) Abdul Mozid et al.   Regenerative Medicine

A neonatal blueprint for cardiac regeneration

(2014) Enzo R. Porrello et al.   Stem Cell Research

Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction

(2014) Maria Patapia Zafiriou et al.   STEM CELLS

Translating Cell-Based Regenerative Medicines from Research to Successful Products: Challenges and Solutions

(2014) Yves Bayon et al.   TISSUE ENGINEERING PART B-REVIEWS

Rationale and Design of the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy (The POSEIDON-DCM Study)

(2014) Muzammil Mushtaq et al.   Journal of Cardiovascular Translational Research

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

(2014) Christian Bär et al.   Nature Communications

Myocardial Tissue Engineering: In Vitro Models

(2014) G. Vunjak Novakovic et al.   Cold Spring Harbor Perspectives in Medicine

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies

(2013) Saeed Abbasalizadeh et al.   BIOTECHNOLOGY ADVANCES

Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function

(2013) Dries Feyen et al.   CARDIOVASCULAR RESEARCH

Reprogramming toward Heart Regeneration: Stem Cells and Beyond

(2013) Aitor Aguirre et al.   Cell Stem Cell

Phase II Clinical Research Design in Cardiology

(2013) Joshua M. Hare et al.   CIRCULATION

Intracoronary Injection of Bone Marrow–Derived Mononuclear Cells Early or Late After Acute Myocardial Infarction

(2013) Daniel Sürder et al.   CIRCULATION

Comparison of Transendocardial and Intracoronary CD34+ Cell Transplantation in Patients With Nonischemic Dilated Cardiomyopathy

(2013) B. Vrtovec et al.   CIRCULATION

Prolyl Hydroxylase Domain Protein 2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium

(2013) Wei Eric Wang et al.   CIRCULATION RESEARCH

Transplantation of Mesenchymal Cells Rejuvenated by the Overexpression of Telomerase and Myocardin Promotes Revascularization and Tissue Repair in a Murine Model of Hindlimb Ischemia

(2013) Rosalinda Madonna et al.   CIRCULATION RESEARCH

Effect of Shock Wave–Facilitated Intracoronary Cell Therapy on LVEF in Patients With Chronic Heart Failure

(2013) Birgit Assmus et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy

(2013) Alan W. Heldman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cardiopoietic Stem Cell Therapy in Heart Failure

(2013) Jozef Bartunek et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction

(2013) S. B. Seif-Naraghi et al.   Science Translational Medicine

Concise Review: Guidance in Developing Commercializable Autologous/Patient-Specific Cell Therapy Manufacturing

(2013) Shannon Eaker et al.   Stem Cells Translational Medicine

Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase–bright stem cells in patients with ischemic heart failure

(2012) Emerson C. Perin et al.   AMERICAN HEART JOURNAL

Cardiac Regenerative Capacity and Mechanisms

(2012) Kazu Kikuchi et al.   Annual Review of Cell and Developmental Biology

AngiomiR-126 expression and secretion from circulating CD34+ and CD14+ PBMCs: role for proangiogenic effects and alterations in type 2 diabetics

(2012) P. Mocharla et al.   BLOOD

Arterial endothelial cells: still the craftsmen of regenerated endothelium

(2012) M. K. Hagensen et al.   CARDIOVASCULAR RESEARCH

G-CSF Stimulation and Coronary Reinfusion of Mobilized Circulating Mononuclear Proangiogenic Cells in Patients with Chronic Ischemic Heart Disease: Five-Year Results of the TOPCARE-G-CSF Trial

(2012) Joerg Honold et al.   CELL TRANSPLANTATION

Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure

(2012) Philipp Jakob et al.   CIRCULATION

Effects of Intracoronary CD34 + Stem Cell Transplantation in Nonischemic Dilated Cardiomyopathy Patients

(2012) Bojan Vrtovec et al.   CIRCULATION RESEARCH

A Randomized, Controlled Pilot Study of Autologous CD34+ Cell Therapy for Critical Limb Ischemia

(2012) Douglas W. Losordo et al.   Circulation-Cardiovascular Interventions

Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure

(2012) Emerson C. Perin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction

(2012) Jay H. Traverse et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency

(2012) Tycho I.G. van der Spoel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Therapeutical potential of autologous peripheral blood mononuclear cell transplantation in patients with type 2 diabetic critical limb ischemia

(2012) Ahmet Ozturk et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction

(2012) Jaco H. Houtgraaf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

(2012) Raj R Makkar et al.   LANCET

Stem cell therapy in ischemic stroke: Role of IV and intra-arterial therapy

(2012) V. Misra et al.   NEUROLOGY

A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction

(2011) Thomas J. Povsic et al.   AMERICAN HEART JOURNAL

A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF)

(2011) Emerson C. Perin et al.   AMERICAN HEART JOURNAL

Endothelial dysfunction as a cellular mechanism for vascular failure

(2011) Tetsuaki Hirase et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease

(2011) T. I. G. van der Spoel et al.   CARDIOVASCULAR RESEARCH

A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia

(2011) Emerson C. Perin et al.   CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication

(2011) Mark A. Creager et al.   CIRCULATION

Intramyocardial, Autologous CD34+ Cell Therapy for Refractory Angina

(2011) Douglas W. Losordo et al.   CIRCULATION RESEARCH

Myocardial blood flow and infarct size after CD133+ cell injection in large myocardial infarction with good recanalization and poor reperfusion: results from a randomized controlled trial

(2011) Alessandro Colombo et al.   Journal of Cardiovascular Medicine

Isolated Coronary Artery Bypass Graft Combined With Bone Marrow Mononuclear Cells Delivered Through a Graft Vessel for Patients With Previous Myocardial Infarction and Chronic Heart Failure

(2011) Shengshou Hu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia

(2011) Jill Belch et al.   LANCET

Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial

(2011) Roberto Bolli et al.   LANCET

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial

(2011) Henricus Duckers et al.   EuroIntervention

CD34+ cell infusion after ST elevation myocardial infarction is associated with improved perfusion and is dose dependent

(2010) Arshed A. Quyyumi et al.   AMERICAN HEART JOURNAL

Results of Intracoronary Stem Cell Therapy After Acute Myocardial Infarction

(2010) Jochen Wöhrle et al.   AMERICAN JOURNAL OF CARDIOLOGY

Cell Therapy, a New Standard in Management of Chronic Critical Limb Ischemia and Foot Ulcer

(2010) V. Procházka et al.   CELL TRANSPLANTATION

Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial

(2010) Jérôme Roncalli et al.   EUROPEAN HEART JOURNAL

Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Prehypertension

(2010) Giovanna Giannotti et al.   HYPERTENSION

Effects of Intracoronary Stem Cell Transplantation in Patients With Dilated Cardiomyopathy

(2010) Bojan Vrtovec et al.   JOURNAL OF CARDIAC FAILURE

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates

(2010) Guillaume Blin et al.   JOURNAL OF CLINICAL INVESTIGATION

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Effect of Intracoronary Injection of Mononuclear Bone Marrow Stem Cells on Left Ventricular Function in Patients With Acute Myocardial Infarction

(2009) Michał Plewka et al.   AMERICAN JOURNAL OF CARDIOLOGY

Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4 years follow-up

(2009) F. Cao et al.   EUROPEAN HEART JOURNAL

Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial

(2009) Michał Tendera et al.   EUROPEAN HEART JOURNAL

One-Year Follow-Up of Feasibility and Safety of the First U.S., Randomized, Controlled Study Using 3-Dimensional Guided Catheter-Based Delivery of Autologous Skeletal Myoblasts for Ischemic Cardiomyopathy (CAuSMIC Study)

(2009) Nabil Dib et al.   JACC-Cardiovascular Interventions

Intramyocardial Bone Marrow Cell Injection for Chronic Myocardial Ischemia

(2009) Jan van Ramshorst et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficiency of Intramyocardial Injections of Autologous Bone Marrow Mononuclear Cells in Patients with Ischemic Heart Failure: A Randomized Study

(2009) Evgeny Pokushalov et al.   Journal of Cardiovascular Translational Research

Intracoronary infusion of autologous mononuclear bone marrow cells in patients with acute myocardial infarction treated with primary PCI: Pilot study of the multicenter HEBE trial

(2008) Alexander Hirsch et al.   CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

Results of a Double-Blind, Placebo-Controlled Study to Assess the Safety of Intramuscular Injection of Hepatocyte Growth Factor Plasmid to Improve Limb Perfusion in Patients With Critical Limb Ischemia

(2008) Richard J. Powell et al.   CIRCULATION

The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial

(2008) Philippe Menasché et al.   CIRCULATION

Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction

(2008) H. V. Huikuri et al.   EUROPEAN HEART JOURNAL

Administration of intracoronary bone marrow mononuclear cells on chronic myocardial infarction improves diastolic function

(2008) K Yao et al.   HEART

Granulocyte-colony stimulating factor or granulocyte-colony stimulating factor associated to stem cell intracoronary infusion effects in non ischemic refractory heart failure

(2008) Edimar Alcides Bocchi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Bone Marrow Cell Therapy Ameliorates and Reverses Chagasic Cardiomyopathy in a Mouse Model

(2008) Regina C. S. Goldenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

(2008) Bin Zhou et al.   NATURE

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE