Article
Cell & Tissue Engineering
Alireza Hosseinpour, Fatemeh Kheshti, Asma Kazemi, Armin Attar
Summary: This study compared the effects of transplantation of bone-marrow mononuclear cells (BM-MNCs) and mesenchymal stem cells (MSCs) on ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). The results showed that both types of cells significantly improved LVEF in the short term, with MSCs being more effective according to the ICEMAN criteria. The effect was even more pronounced in patients who received stem cell transplantation in the early course after AMI.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Xun Wu, Di Wang, Kele Qin, Chukwuemeka Daniel Iroegbu, Kun Xiang, Yuanjing Zhou, Qing Guan, Weijie Tang, Jun Peng, Jianjun Guo, Jinfu Yang, Chengming Fan
Summary: Echocardiography-guided multiple percutaneous left ventricular intramyocardial injection of hiPSC-CMs is a feasible, satisfactory, repeatable, relatively less invasive, and effective method for delivering cell therapy to improve left ventricular function, infarct size, angiogenesis, cardiac remodeling, and cardiomyocyte apoptosis after MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alireza Hosseinpour, Hamidreza Hosseinpour, Armin Attar
Summary: In patients with acute myocardial infarction (AMI), transplantation of bone marrow mononuclear cells (BM-MNC) may reduce the risk of hospitalization for heart failure in the long term. However, its effect on all-cause mortality and stroke rate remains uncertain.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Armin Attar, Alireza Hosseinpour, Hamidreza Hosseinpour, Asma Kazemi
Summary: This meta-analysis reveals that transplantation of BM-MNCs may reduce the risk of major adverse cardiovascular events, such as hospitalization for congestive heart failure, re-infarction, and cardiac-related mortality, after acute myocardial infarction.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Yibing Nong, Yiru Guo, Alex Tomlin, Xiaoping Zhu, Marcin Wysoczynski, Qianhong Li, Roberto Bolli
Summary: In the field of cell therapy for heart disease, a new paradigm of repeated dosing of cells has emerged. A method of echo-guided LV injection has been established for cell delivery in infarcted mice, with a high survival rate and improved cardiac function. This method provides a feasible, reproducible, less invasive, and effective delivery approach for cell therapy in murine heart disease models.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Zachi I. Attia, David M. Harmon, Jennifer Dugan, Lukas Manka, Francisco Lopez-Jimenez, Amir Lerman, Konstantinos C. Siontis, Peter A. Noseworthy, Xiaoxi Yao, Eric W. Klavetter, John D. Halamka, Samuel J. Asirvatham, Rita Khan, Rickey E. Carter, Bradley C. Leibovich, Paul A. Friedman
Summary: This study finds that consumer watch ECGs can be used to identify cardiac dysfunction, potentially serving as an early warning system for heart failure.
Article
Biochemistry & Molecular Biology
Eun-Hye Park, Jin-Moo Kim, Eunhwa Seong, Eunmi Lee, Kiyuk Chang, Young Choi
Summary: The effects of injecting mesenchymal stem cells (MSCs) into the scar border zone on arrhythmic risks in a post-myocardial infarction (MI) animal model were evaluated. The results showed that MSC injections did not increase the risk of ventricular tachycardia (VT) and were associated with favorable connexin 43 (Cx43) expression and arrangement.
Article
Immunology
Zheng Wu, Shujuan Cheng, Shaoping Wang, Wenzheng Li, Jinghua Liu
Summary: The study showed that exosomal miR-150-5p derived from bone marrow mesenchymal stem cells can attenuate cardiomyocyte apoptosis through targeting Bax and improve cardiac function in myocardial infarction mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Anton Camaj, Valentin Fuster, Gennaro Giustino, Solomon W. Bienstock, David Sternheim, Roxana Mehran, George D. Dangas, Annapoorna Kini, Samin K. Sharma, Jonathan Halperin, Marc R. Dweck, Martin E. Goldman
Summary: The incidence of left ventricular (LV) thrombus following acute myocardial infarction has declined due to advancements in reperfusion and antithrombotic therapies. Embolic events remain a significant concern and require systemic anticoagulation. LV thrombus development depends on Virchow's triad, and diagnostic modalities include echocardiography and cardiac magnetic resonance. Vitamin K antagonists are the mainstay of therapy, with limited evidence for the use of direct oral anticoagulants.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Ross T. Campbell, Katriona J. M. Brooksbank, John G. Dreisbach, Paul Forsyth, Rosemary L. Godeseth, Tracey Hopkins, Alice M. Jackson, Matthew M. Y. Lee, Alex McConnachie, Giles Roditi, Iain B. Squire, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J. V. McMurray
Summary: In patients with asymptomatic LV systolic dysfunction late after myocardial infarction, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.
Article
Cardiac & Cardiovascular Systems
Ahmet Demirkiran, Rob J. van der Geest, Luuk H. G. A. Hopman, Lourens F. H. J. Robbers, M. Louis Handoko, Robin Nijveldt, John P. Greenwood, Sven Plein, Pankaj Garg
Summary: LV hemodynamic assessment by LV blood flow kinetic energetics in STEMI patients shows a significant inverse association with adverse LV-remodeling. Late-diastolic LV blood flow kinetic energetics early after acute MI is independently associated with adverse LV-remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elena Michelucci, Silvia Rocchiccioli, Melania Gaggini, Rudina Ndreu, Sergio Berti, Cristina Vassalle
Summary: This study found that specific ceramide species are associated with cardiovascular risk, inflammation, and disease severity in acute myocardial infarction (AMI). A detailed analysis of ceramides may help to better understand cardiovascular pathobiology and suggest these new biomarkers as possible risk predictors and pharmacological targets in AMI patients.
Article
Peripheral Vascular Disease
Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto Di Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, Jose Luis Diez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-Yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Ciro De Simone, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Jose Moreu, Vincent Flavien, Enrico Fabris, Inigo Lozano Martinez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Fores, Luigi Vignali, Helder Pereira, Stephane Manzo-Silbermann, Santiago Ordonez, Alev Arat Ozkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, Joao Antonio Brum Silveira, Ivan Bessonov, Rodrigo Zoni, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopoulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Anne Bellemain-Appaix, Gustavo Pessah, Giuliana Cortese, Guido Parodi, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia
Summary: This study aimed to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in STEMI patients undergoing primary PCI. The results showed that SARS-CoV-2 positive patients had more complications and higher mortality post procedure, indicating the association between SARS-CoV-2 positivity and impaired reperfusion with negative prognostic consequences.
Review
Biotechnology & Applied Microbiology
Pawel Robak, Tadeusz Robak
Summary: In recent years, there have been significant advancements in the treatment of chronic lymphocytic leukemia (CLL), including the use of novel targeted drugs and monoclonal antibodies. Combination therapies with different agents have shown high activity in both treatment naive and relapsed/refractory CLL patients. However, more research is needed to determine the optimal sequencing of therapies and selection of upfront treatment options.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Review
Pharmacology & Pharmacy
Aleksandra Golos, Joanna Gora-Tybor, Tadeusz Robak
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Biochemistry & Molecular Biology
Anna Pula, Pawel Robak, Dariusz Jarych, Damian Mikulski, Malgorzata Misiewicz, Izabela Drozdz, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak
Summary: This study aimed to analyze the expression of selected miRNAs in the serum of MM patients treated with bortezomib-based regimens and determine their ability to predict early mortality. Two miRNAs, hsa-miR-328-3p and hsa-miR-409-3p, were significantly downregulated in the early mortality group. Logistic regression analysis showed that the final model, including these miRNAs, age, and R-ISS 3, had high sensitivity and specificity in predicting early mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Peter Hillmen, Barbara Eichhorst, Jennifer R. Brown, Nicole Lamanna, Susan M. O'Brien, Constantine S. Tam, Lugui Qiu, Maciej Kazmierczak, Keshu Zhou, Martin Simkovic, Jiri Mayer, Amanda Gillespie-Twardy, Mazyar Shadman, Alessandra Ferrajoli, Peter S. Ganly, Robert Weinkove, Sebastian Grosicki, Andrzej Mital, Tadeusz Robak, Anders Osterborg, Habte A. Yimer, Tommi Salmi, Meng Ji, Jessica Yecies, Adam Idoine, Kenneth Wu, Jane Huang, Wojciech Jurczak
Summary: The study compared the efficacy and safety of zanubrutinib and ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia. The results showed that zanubrutinib had better outcomes in terms of efficacy, atrial fibrillation rate, and cardiac safety compared to ibrutinib.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tadeusz Robak, Pawel Robak
Summary: This article summarizes recent achievements in the treatment of relapsed and refractory hairy cell leukemia. The growing understanding of HCL biology has led to the development of several new targeted drugs, which have shown promising efficacy in early clinical trials.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Oncology
Talha Munir, Carol Moreno, Carolyn Owen, George Follows, Ohad Benjamini, Ann Janssens, Mark-David Levin, Anders Osterborg, Tadeusz Robak, Martin Simkovic, Don Stevens, Sergey Voloshin, Vladimir Vorobyev, Munci Yagci, Loic Ysebaert, Keqin Qi, Qianya Qi, Lori Parisi, Srimathi Srinivasan, Natasha Schuier, Kurt Baeten, Angela Howes, Donne Bennett Caces, Carsten U. U. Niemann, Arnon P. P. Kater
Summary: In the GLOW study, fixed-duration ibrutinib + venetoclax treatment showed better progression-free survival (PFS) compared to chlorambucil + obinutuzumab in older/comorbid patients with previously untreated CLL. This analysis examines the kinetics of minimal residual disease (MRD) and its predictive value for PFS, which has not been evaluated for ibrutinib + venetoclax treatment.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Tadeusz Robak, Jaroslaw D. Kasprzak, Dorota Jesionek-Kupnicka, Michal Soin, Pawel Robak
LEUKEMIA & LYMPHOMA
(2023)
Editorial Material
Oncology
Tadeusz Robak
LEUKEMIA & LYMPHOMA
(2023)
Article
Hematology
Pierre Fenaux, Marco Gobbi, Patricia L. Kropf, Jean-Pierre J. Issa, Gail J. Roboz, Jiri Mayer, Juergen Krauter, Tadeusz Robak, Hagop Kantarjian, Jan Novak, Wieslaw. W. Jedrzejczak, Xavier Thomas, Mario Ojeda-Uribe, Yasushi Miyazaki, Yoo Hong Min, Su-Peng Yeh, Joseph Brandwein, Liana Gercheva-Kyuchukova, Judit Demeter, Elizabeth Griffiths, Karen Yee, Konstanze Doehner, Yong Hao, Harold Keer, Mohammad Azab, Hartmut Doehner
Summary: This phase 3 study compared the efficacy and safety of the hypomethylating agent guadecitabine with other treatment choices in patients with acute myeloid leukemia unfit for intensive induction chemotherapy. The study found no significant difference in complete remission and overall survival between guadecitabine and the alternative treatments.
Review
Biochemistry & Molecular Biology
Magdalena Witkowska, Agata Majchrzak, Pawel Robak, Anna Wolska-Washer, Tadeusz Robak
Summary: PI3K & delta; inhibitors are novel agents used to treat B-cell malignancies by inhibiting enzymes in the PI3K/AKT/mTOR pathway. Idelalisib is an effective inhibitor for B-cell lymphoid malignancies.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Oncology
Mikkael A. Sekeres, Pau Montesinos, Jan Novak, Jianxiang Wang, Deepa Jeyakumar, Benjamin Tomlinson, Jiri Mayer, Erin Jou, Tadeusz Robak, David C. Taussig, Herve Dombret, Akil Merchant, Naveed Shaik, Thomas O'Brien, Whijae Roh, Xueli Liu, Wendy Ma, Christine G. DiRienzo, Geoffrey Chan, Jorge E. Cortes
Summary: This is the primary report of the BRIGHT AML 1019 clinical trial, which investigated the use of glasdegib in combination with intensive or non-intensive chemotherapy for untreated acute myeloid leukemia patients. The study found that there was no significant improvement in overall survival when glasdegib was added to either chemotherapy regimen. The occurrence of treatment-emergent adverse events was similar between the glasdegib and placebo groups. Clinical trial registration: ClinicalTrials.gov: NCT03416179.
Letter
Oncology
Tara Cochrane, Alicia Enrico, David Gomez-Almaguer, Evgueniy Hadjiev, Ewa Lech-Maranda, Tamas Masszi, Eugene Nikitin, Tadeusz Robak, Robert Weinkove, Shang-Ju Wu, Beenish S. Manzoor, Todd Busman, Madhavi Pai, Viktor Komlosi, Mary Ann Anderson
LEUKEMIA & LYMPHOMA
(2023)
Article
Medicine, General & Internal
Angela Zagatina, Maria Rivadeneira Ruiz, Quirino Ciampi, Karina Wierzbowska-Drabik, Jaroslaw Kasprzak, Elena Kalinina, Irina Begidova, Jesus Peteiro, Rosina Arbucci, Sofia Marconi, Jorge Lowenstein, Alla Boshchenko, Fiore Manganelli, Jelena Celutkiene, Doralisa Morrone, Elisa Merli, Federica Re, Clarissa Borguezan-Daros, Maciej Haberka, Ariel K. Saad, Ana Djordjevic-Dikic, Nithima Chaowalit Ratanasit, Fausto Rigo, Paolo Colonna, Jose Luis de Castro e Silva Pretto, Fabio Mori, Maria Grazia D'Alfonso, Miodrag Ostojic, Bojan Stanetic, Tamara Kovacevic Preradovic, Fabio Costantino, Andrea Barbieri, Rodolfo Citro, Annalisa Pitino, Mauro Pepi, Scipione Carerj, Patricia A. Pellikka, Eugenio Picano
Summary: In patients with chronic coronary syndromes, left atrial dilation and reservoir dysfunction are often present in paroxysmal and permanent atrial fibrillation. These abnormalities are associated with more frequent inducible ischemia and pulmonary congestion during stress.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Tadeusz Robak, Anna Krawczynska, Barbara Cebula-Obrzut, Marta Urbaniak, Elzbieta Iskierka-Jazdzewska, Pawel Robak
Summary: Differentiation of leukemic cells in CLL is significant, with dissimilarities in morphology, cytogenetics, and immunophenotype. Atypical CLL differs from typical CLL morphologically and immunophenotypically, with more aggressive clinical behavior and worse prognosis. However, there is no standard criteria for differentiating atypical CLL from typical CLL and its clinical significance is still under debate.
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)