4.5 Editorial Material

Clinical development plan for regenerative therapy in heart failure

期刊

EUROPEAN JOURNAL OF HEART FAILURE
卷 18, 期 2, 页码 142-144

出版社

WILEY
DOI: 10.1002/ejhf.479

关键词

-

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Engineering, Biomedical

Correction of High Afterload Improves Low Cardiac Output in Patients Supported on Left Ventricular Assist Device Therapy

Andrew N. Rosenbaum, Alfredo L. Clavell, John M. Stulak, Atta Behfar

Summary: There is a lack of data on the invasive assessment of afterload and its impact on cardiac output in patients on LVAD therapy. Despite no direct association between mean aortic pressure (MAP) and cardiac index (CI), varying MAP levels led to different cardiac output responses to speed increments. Patients with elevated MAP were found to benefit from nitrate therapy, demonstrating improved biventricular filling pressures and increased cardiac index. High afterload in LVAD patients is common, but can be improved with nitrates, highlighting the importance of further research on the effects of high afterload and chronic vasodilator therapy in this patient population.

ASAIO JOURNAL (2021)

Article Engineering, Biomedical

Inadequate left ventricular unloading during ramp is associated with hospitalization or death during left ventricular assist device support

Andrew N. Rosenbaum, John M. Stulak, Alfredo L. Clavell, Atta Behfar

Summary: This study evaluated the prognostic significance of hemodynamic indices in LVAD patients and found that LVEDP is a central prognostic marker in this population.

ARTIFICIAL ORGANS (2021)

Article Engineering, Biomedical

Outcomes of Ambulatory Heart Failure Patients Managed With an Intra-aortic Balloon Pump Before Left Ventricular Assist Device Implantation

Bradley Ternus, Atta Behfar, John Schirger, Gregory Barsness, Mackram Eleid, Parag Patel, John Stulak, Jacob Jentzer

Summary: This study aimed to evaluate the clinical outcomes of hemodynamic optimization using IABP in high-risk heart failure patients before LVAD implantation. The results showed that patients treated with IABP before LVAD implantation had better reductions in pulmonary artery pressures without an increase in postoperative complications.

ASAIO JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Systolic-to-diastolic myocardial volume ratio as a novel imaging marker of cardiomyopathy

Alexander J. Ryu, Vinayak Kumar, Barry A. Borlaug, Armando Manduca, Chaitanya K. Rao, Raymond J. Gibbons, Samuel J. Asirvatham, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Nandan S. Anavekar

Summary: The study investigated the ratio of myocardial volume in systole to myocardial volume in diastole (MVs/MVd) to differentiate between normal hearts and various cardiomyopathies with normal ejection fractions. Results showed significant differences in MVs/MVd ratio between pathological subgroups and normal subjects, suggesting its potential as a novel and easily-captured metric for assessing ventricular function. The study concluded that MVs/MVd ratio can effectively distinguish normal ventricular function from different cardiomyopathies, indicating its clinical utility in assessing heart disease.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Risk of Liver Dysfunction After Left Ventricular Assist Device Implantation

Andrew N. Rosenbaum, Bradley W. Ternus, Siddharth Pahwa, John M. Stulak, Alfredo L. Clavell, Sarah D. Schettle, Atta Behfar, Jacob C. Jentzer

Summary: In patients undergoing left ventricular assist device implantation, right ventricular stroke work index, right heart catheterization, cardiopulmonary bypass time, and ultrafiltration are strongly associated with incident INT-LD and decreased 1-year survival. Optimization of these factors may reduce the risk of liver dysfunction but further validation is needed.

ANNALS OF THORACIC SURGERY (2021)

Article Engineering, Biomedical

Percutaneous Axillary Intra-aortic Balloon Pump Insertion Technique as Bridge to Advanced Heart Failure Therapy

Andrew N. Rosenbaum, C. Charles Jain, Ilya Y. Shadrin, Stephanie C. El Hajj, Abdallah El Sabbagh, Atta Behfar

Summary: In patients with advanced heart failure, the use of percutaneous axillary intra-aortic balloon pump for temporary mechanical circulator support is feasible and associated with an acceptable complication rate as a bridge to definitive therapy, facilitating ambulation and improving outcomes.

ASAIO JOURNAL (2021)

Article Cell & Tissue Engineering

Brachyury engineers cardiac repair competent stem cells

Mark Li, Satsuki Yamada, Ao Shi, Raman Deep Singh, Tyler J. Rolland, Ryounghoon Jeon, Natalia Lopez, Lukas Shelerud, Andre Terzic, Atta Behfar

Summary: By introducing early cardiogenic genes, engineered cardiac repair competent stem cells with antioxidant, vasculogenic, and immunomodulatory traits have been successfully developed. These stem cells have important application value in treating heart diseases such as ischemic heart failure.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Heart-After-Liver Transplantation Attenuates Rejection of Cardiac Allografts in Sensitized Patients

Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha

Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Cell & Tissue Engineering

Regenerative medicine clinical readiness

Satsuki Yamada, Atta Behfar, Andre Terzic

Summary: Regenerative medicine aims to provide more care options for patients in need through technological innovation, helping them to get cured. Through responsible and regulated translation, regenerative medical technology is applied to the treatment of serious diseases and disabilities. By advancing the design, manufacture, and effectiveness of regenerative solutions, the goal is to democratize health benefits for all.

REGENERATIVE MEDICINE (2021)

Article Obstetrics & Gynecology

Impact of Repeat Dosing and Mesh Exposure Chronicity on Exosome-Induced Vaginal Tissue Regeneration in a Porcine Mesh Exposure Model

Cassandra K. Kisby, Ilya Y. Shadrin, Lillian T. Peng, Paul G. Stalboerger, Emanuel C. Trabuco, Atta Behfar, John A. Occhino

Summary: The study compared vaginal wound healing in a porcine mesh exposure model after exosome injection, looking at single vs. multiple dose regimens and acute vs. subacute exposure. Results showed that redosing with exosomes led to significantly higher epithelial proliferation and regenerated capillary density, with a trend towards thicker epithelium. Subacute exposure demonstrated similar regeneration to acute exposure despite a delayed injection timeline.

FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY (2021)

Editorial Material Medicine, General & Internal

Listening for Thrombosis

Michael S. Sabbah, Andrew N. Rosenbaum, Atta Behfar

MAYO CLINIC PROCEEDINGS (2021)

Editorial Material Cell & Tissue Engineering

From tissue to human regeneration: the development of a comprehensive regenerative care clinic for people with diabetes

Ian G. Hargraves, Atta Behfar, Vinaya Simha, Chenoa Donoghue, Amy Seegmiller Renner, Victor M. Montori, Juan P. Brito

REGENERATIVE MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

An under-recognized phenomenon: Myocardial volume change during the cardiac cycle

Vinayak Kumar, Armando Manduca, Chaitanya Rao, Alexander J. Ryu, Raymond J. Gibbons, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Samuel J. Asirvatham, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Barry A. Borlaug, Nandan S. Anavekar

Summary: This study analyzed myocardial strain values from healthy patients and found that myocardial volume decreases during systole. Sensitivity analysis showed that strain values are the primary determinant of myocardial volume changes.

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES (2021)

Article Cell & Tissue Engineering

Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome

D. Kent Arrell, Ruben J. Crespo-Diaz, Satsuki Yamada, Ryounghoon Jeon, Armin Garmany, Sungjo Park, Jeffrey P. Adolf, Christopher Livia, Matthew L. Hillestad, Jozef Bartunek, Atta Behfar, Andre Terzic

Summary: Stem cell paracrine activity, specifically secreted proteins by cardiopoietic cells, play a key role in cardiac repair. Through systems analytics and RNA sequencing, miR-146 was identified as a regulator upstream of the decoded secretome. The therapeutic impact of cardiopoietic cell therapy on infarcted hearts is influenced by the inherent vasculogenic properties and smooth muscle differentiation of the secreted proteins.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Medicine, Research & Experimental

TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo

Ao Shi, Jialun Li, Xinyuan Qiu, Michael Sabbah, Soulmaz Boroumand, Tony Chieh-Ting Huang, Chunfeng Zhao, Andre Terzic, Atta Behfar, Steven L. Moran

Summary: This study developed a clinical-grade platelet exosome product (PEP) combined with injectable surgical fibrin sealant (TISSEEL) to promote chronic wound healing and skin regeneration. The PEP showed promising results in stimulating cellular activities and enhancing wound healing capacity.

THERANOSTICS (2021)

暂无数据