Article
Multidisciplinary Sciences
Weronika Wargocka-Matuszewska, Katarzyna Fiedorowicz, Anna Rugowska, Karolina Bednarowicz, Agnieszka Zimna, Lukasz Cheda, Paulina Hamankiewicz, Krzysztof Kilian, Michal Fiedorowicz, Monika Drabik, Natalia Rozwadowska, Zbigniew Rogulski, Maciej Kurpisz
Summary: This study utilized in vivo imaging techniques to monitor the effects of stem cell transplantation in mice with myocardial infarction, showing that transplanted stem cells survived and proliferated over a 5-week period, improving cardiac metabolic and hemodynamic parameters.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Hanne Belien, Lize Evens, Marc Hendrikx, Virginie Bito, Annelies Bronckaers
Summary: Myocardial infarction, the leading cause of heart failure worldwide, has sparked interest in stem cell therapy for cardiac repair. While some successful results have been achieved in animal models, the overall outcome of clinical trials has been disappointing, mainly due to limited stem cell survival and retention. Combinational use of stem cells and various priming strategies may hold promise for improving regenerative cell therapy efficacy.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Ke Zhu, Dawei Jiang, Kun Wang, Danzha Zheng, Ziyang Zhu, Fuqiang Shao, Ruijie Qian, Xiaoli Lan, Chunxia Qin
Summary: In this study, a new conductive nanocomposite hydrogel was developed by incorporating gold nanorods and synthetic silicate nanoplatelets, and using a poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) as a matrix to encapsulate mesenchymal stem cells and a tracer. The combination of MSCs and the conductive hydrogel showed potential therapeutic effects in improving myocardial viability and cardiac function in MI rats, as revealed by imaging techniques such as PET and ultrasound.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Yu-Yan Xiong, Zhao-Ting Gong, Rui-Jie Tang, Yue-Jin Yang
Summary: AMI is a leading cause of mortality globally, with inflammatory response playing a pivotal role in myocardial necrosis and ventricular remodeling. Exosomes, containing biologically active substances, have emerged as key players in immune regulation post AMI, alongside a variety of immune cells working together for tissue cleanup and repair. Research into exosomes from both endogenous immune cells and exogenous stem cells has shown promising therapeutic effects in immunomodulation for myocardial repair post AMI.
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Engineering, Biomedical
Peier Chen, Xiaodong Ning, Weirun Li, Yuxuan Pan, Ling Wang, Hekai Li, Xianglin Fan, Jiexin Zhang, Tiantian Luo, Yaobin Wu, Caiwen Ou, Minsheng Chen
Summary: This study developed artificial stem cells that can continuously release T beta 4-exosomes, which greatly promote coronary collateralization and provide a feasible and alternative method for clinical revascularization after myocardial infarction. The artificial stem cells showed a better therapeutic effect than direct injection of exosomes. The mechanism involves the enhancement of angiogenic capacity of coronary endothelial cells through the miR-17-5p/PHD3/Hif-1 alpha pathway.
BIOACTIVE MATERIALS
(2022)
Review
Cell Biology
Moein Ala
Summary: Mesenchymal stem cells (MSCs) have regenerative, anti-inflammatory, and immunomodulatory properties. They attenuate various detrimental effects after myocardial infarction (MI) and improve cardiac function. MSC-derived exosomes also show promising effects in MI treatment. However, there are still modifiable factors that need to be optimized, such as timing and route of administration, as well as MSC pretreatment approaches. Future clinical trials should consider these advances to accurately assess the efficacy of MSCs or their exosomes for MI.
AGEING RESEARCH REVIEWS
(2023)
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyan Gao, Xiaoting Liang, Baojuan Liu, Yimei Hong, Haiwei He, Ying Shen, Jiaqi Chen, Xinran Huang, Bei Hu, Weifeng Li, Xin Li, Yuelin Zhang
Summary: In this study, the role of ALKBH5 in regulating the senescence of mesenchymal stem cells (MSCs) was investigated. ALKBH5 was found to accelerate MSC senescence through the regulation of m6A modification and stability of CDKN1C mRNA. Knockdown of ALKBH5 rejuvenated aged MSCs and improved their therapeutic efficacy for myocardial infarction.
Article
Engineering, Environmental
Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng, Juan Wang
Summary: A comparison between intramyocardial (IM) injection and intrapericardial cavity (IPC) injection of adult stem cells in hydrogel showed that IPC injection led to better retention and therapeutic benefits, resulting in significant improvement in cardiac function. Furthermore, IPC delivery demonstrated better cellular proliferation, less apoptosis, and improved vascular regeneration in the myocardium. Additionally, IPC injections led to higher rates of MSC-exosome absorption by heart cells, indicating more extensive paracrine activity and showing promise as a solution for the low retention issue of MSCs in the infarcted heart.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Shuoji Zhu, Changjiang Yu, Nanbo Liu, Mingyi Zhao, Zerui Chen, Jian Liu, Ge Li, Huanlei Huang, Huiming Guo, Tucheng Sun, Jimei Chen, Jian Zhuang, Ping Zhu
Summary: The study found that using GelMA-O5/rGO hydrogel encapsulating UCMSCs could significantly improve damaged myocardial tissue and reconstruct myocardial function, which may be a promising therapeutic strategy for cardiac repair.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Huihui He, Yuan Yuan, Yunhong Wu, Jingyi Lu, Xiaofu Yang, Kejie Lu, An Liu, Zelin Cao, Miao Sun, Mengfei Yu, Huiming Wang
Summary: The integration of metal-organic frameworks exoskeletons with bone marrow stem cells (BMSCs) improves cell survival and enhances cardiac repair. The partially coated cells are able to withstand detrimental environmental conditions and promote cell adhesion. The interaction between exoskeletons and cell surface receptors leads to altered gene expression and enhanced biological functions.
ADVANCED MATERIALS
(2023)
Article
Cell & Tissue Engineering
Alireza Hosseinpour, Fatemeh Kheshti, Asma Kazemi, Armin Attar
Summary: This study compared the effects of transplantation of bone-marrow mononuclear cells (BM-MNCs) and mesenchymal stem cells (MSCs) on ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). The results showed that both types of cells significantly improved LVEF in the short term, with MSCs being more effective according to the ICEMAN criteria. The effect was even more pronounced in patients who received stem cell transplantation in the early course after AMI.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: This study found that pretreatment of mesenchymal stem cells (MSCs) with the Chinese medicine Tongxinluo (TXL) can enhance cardiac repair in acute myocardial infarction (AMI) by transferring miR-146a-5p through exosomes to target the IRAK1/NF-kappa B p65 pathway. This has significant potential for clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Domenico Albano, Francesco Bertagna, Pierpaolo Alongi, Sergio Baldari, Alfonso Baldoncini, Mirco Bartolomei, Franco Boccaletto, Michele Boero, Eugenio Borsatti, Andrea Bruno, Luca Burroni, Francesca Capoccetti, Massimo Castellani, Anna Rita Cervino, Franca Chierichetti, Andrea Ciarmiello, Angelo Corso, Alberto Cuocolo, Maria Luisa De Rimini, Desiree Deandreis, Massimo Eugenio Dottorini, Filomena Esposito, Mohsen Farsad, Massimo Gasparini, Chiara Maria Grana, Michele Gregianin, Luca Guerra, Fabio Loreti, Andrea Lupi, Gianluigi Martino, Elisa Milan, Sergio Modoni, Silvia Morbelli, Alfredo Muni, Emanuele Nicolai, Barbara Palumbo, Sergio Papa, Alberto Papaleo, Riccardo Pellerito, Carlo Poti, Pasquale Romano, Claudio Rossetti, Pierluigi Rossini, Giuseppe Rubini, Livia Ruffini, Gianmauro Sacchetti, Giordano Savelli, Saverio Schiavariello, Roberto Sciagra, Rosa Sciuto, Ettore Seregni, Stelvio Sestini, Michele Sicolo, Angela Spanu, Giovanni Storto, Massimo Tosti Balducci, Giuseppe Trifiro, Annibale Versari, Alberto Vignati, Duccio Volterrani, Maria Lucia Calcagni, Maria Cristina Marzola, Antonio Garufo, Laura Evangelista, Roberto Maroldi, Orazio Schillaci, Raffaele Giubbini
Summary: The study assessed the incidental interstitial lung alterations suspicious of COVID-19 on [F-18]FDG PET/CT in asymptomatic oncological patients in Italy during active COVID-19 period. The prevalence of interstitial pneumonia was significantly higher during the COVID period, directly correlating with geographic virus diffusion in Northern Italy. Majority of the interstitial pneumonia detected were FDG-avid, highlighting the importance of recognizing early COVID-19 cases through incidental CT findings.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Enrique Gomez-Barrena, Norma G. Padilla-Eguiluz, Philippe Rosset, Philippe Hernigou, Nicola Baldini, Gabriela Ciapetti, Rosa M. Gonzalo-Daganzo, Cristina Avendano-Sola, Helene Rouard, Rosaria Giordano, Massimo Dominici, Hubert Schrezenmeier, Pierre Layrolle
Summary: The study demonstrated the safety and early efficacy of treating early femoral head osteonecrosis with autologous mesenchymal stromal cells (MSC) expanded from bone marrow. Results showed that 80% of patients maintained head sphericity and showed bone regeneration at 2 years, with 19% converting to total hip replacement (THR) after 5 years.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Serena M. Passamonti, Andrea Artoni, Giorgio Carrabba, Giuliana Merati, Maria Abbattista, Marco Capecchi, Massimo Castellani, Cristina Marenghi, Elena Trombetta, Lorenzo Giammattei, Manuela Caroli, Paolo Bucciarelli, Erica Scalambrino, Flora Peyvandi, Ida Martinelli
Summary: The study found that levels of certain EVs were already significantly increased before surgery in patients with meningioma and glioma, and in glioma patients who developed PE, specific types of EVs were significantly elevated within 24 hours and 48 hours after surgery.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Medicine, Research & Experimental
Cristiana Lavazza, Silvia Budelli, Elisa Montelatici, Mariele Vigano, Francesca Ulbar, Lucia Catani, Marta Giulia Cannone, Sara Savelli, Elisa Groppelli, Lorenza Lazzari, Roberto M. Lemoli, Matteo Cescon, Gaetano La Manna, Rosaria Giordano, Tiziana Montemurro
Summary: This study validates a Good Manufacturing Practice (GMP)-compliant protocol for the production of T-reg cells, which enables the generation of a sufficient number of functional T-reg cells with immunomodulatory properties. These results are important for implementing cell therapy protocols aimed at restoring T-reg cell number and function, and slowing the progression of certain diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Rosaria Giordano, Margherita Canesi, Maurizio Isalberti, Giovanni Marfia, Rolando Campanella, Daniele Vincenti, Viviana Cereda, Alessandra Ranghetti, Chiara Palmisano, Ioannis Ugo Isaias, Riccardo Benti, Giorgio Marotta, Lorenza Lazzari, Tiziana Montemurro, Mariele Vigano, Silvia Budelli, Elisa Montelatici, Cristiana Lavazza, Araceli Rivera-Ordaz, Gianni Pezzoli
Summary: This study assessed the safety of MSC treatment in patients with PSP and identified critical issues in cell therapies for neurodegenerative diseases. The results showed that MSC treatment did not have a significant impact on 1-year survival rate and occurrence of adverse events in most treated patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Microbiology
Paolo Rebulla, Daniele Prati
Summary: This article reviews the development of pathogen reduction technologies for platelets and describes complementary strategies recommended by the US FDA. The reviewed studies show significant progress in this field, but further efforts are needed.
Article
Medicine, General & Internal
Angelo Castello, Massimo Castellani, Luigia Florimonte, Luca Urso, Luigi Mansi, Egesta Lopci
Summary: The introduction of immune checkpoint inhibitors has been a major breakthrough in cancer treatment. The search for complementary non-invasive biomarkers to better select patients before therapy is still ongoing. Radiomics, as an emerging approach, can extract multiple features from medical images and clinical data that are not easily visible to the human eye, and has the potential to predict response and survival in immunotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Luca Urso, Luigi Manco, Angelo Castello, Laura Evangelista, Gabriele Guidi, Massimo Castellani, Luigia Florimonte, Corrado Cittanti, Alessandro Turra, Stefano Panareo
Summary: Breast cancer is a major cause of death among women, but the heterogeneity of the disease makes it challenging to identify valuable biomarkers and optimal treatment approaches. Radiomics and artificial intelligence have shown promise in detecting previously unseen features in medical images of breast cancer, aiding in staging, prognosis, and biological assessment. However, larger prospective trials are needed to confirm and standardize the application of these new techniques in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Matteo Caracciolo, Angelo Castello, Luca Urso, Francesca Borgia, Naima Ortolan, Licia Uccelli, Corrado Cittanti, Massimo Castellani, Mirco Bartolomei, Massimo Lazzeri, Egesta Lopci
Summary: This study systematically evaluates the role of [Ga-68]PSMA PET/CT for clinical suspicions of prostate cancer. It shows that [Ga-68]PSMA PET/CT is more accurate than mpMRI in identifying primary prostate cancer with PSA values between 4 and 20 ng/mL, and the combination of PSMA PET/CT and MRI improves sensitivity for clinically significant prostate cancer detection.
Review
Medicine, General & Internal
Marco Chiappetta, Paolo Mendogni, Margherita Cattaneo, Jessica Evangelista, Piero Farina, Daniele Antonio Pizzuto, Salvatore Annunziata, Angelo Castello, Maria Teresa Congedo, Diomira Tabacco, Carolina Sassorossi, Massimo Castellani, Mario Nosotti, Stefano Margaritora, Filippo Lococo
Summary: Thymic epithelial tumours are rare and insidious malignancies that can be histologically classified into different WHO subtypes. (18)FDG PET/CT scan has been reported to play a remarkable role in predicting histology in these tumours. This narrative review summarizes the current evidence on this topic and discusses potential applications.
Review
Oncology
Luca Urso, Elena Bonatto, Alberto Nieri, Angelo Castello, Anna Margherita Maffione, Maria Cristina Marzola, Corrado Cittanti, Mirco Bartolomei, Stefano Panareo, Luigi Mansi, Egesta Lopci, Luigia Florimonte, Massimo Castellani
Summary: This review highlights the crucial role of molecular imaging, specifically using PET radiotracers, in the evaluation of patients with brain metastases. It outlines the current application and future prospects of PET radiotracers, including radiomics and theranostics approaches. The evidence confirms the significance of amino acid PET radiotracers in delineating tumor extension, assessing therapy response, and differentiating between tumor progression and radionecrosis.
Article
Medicine, General & Internal
Luca Urso, Angelo Castello, Giorgio Treglia, Stefano Panareo, Alberto Nieri, Ilaria Rambaldi, Matteo Caracciolo, Naima Ortolan, Licia Uccelli, Corrado Cittanti, Massimo Castellani, Mirco Bartolomei
Summary: This study aims to explore the prognostic and predictive role of volumetric parameters on [Ga-68]Ga-DOTATOC PET/CT in NET patients treated with PRRT. The results suggest the importance of evaluating the burden of disease on PRRT in NET patients.
Review
Medicine, General & Internal
Luca Urso, Luca Filippi, Angelo Castello, Maria Cristina Marzola, Mirco Bartolomei, Corrado Cittanti, Luigia Florimonte, Massimo Castellani, Paolo Zucali, Alessio Bruni, Roberto Sabbatini, Massimo Dominici, Stefano Panareo, Laura Evangelista
Summary: PSMA ligand PET has higher detection rates compared to conventional imaging in CRPC patients, reducing the number of M0 CRPC patients. However, its impact on patients' prognosis is still uncertain. Additionally, PSMA ligand PET has sensitivity and specificity limitations in CRPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Katia Chieregato, Martina Bernardi, Alberta Alghisi, Rosaria Giordano, Lorenza Lazzari, Omar Perbellini, Mario Rassu, Marco Ruggeri, Giuseppe Astori
Summary: Mesenchymal stromal cells (MSC) have potential in treating aGvHD and autoimmune disorders, but their recognition mechanisms are unclear and they are not completely immunoprivileged. Developing an in vitro test and a flow cytometric assay may be an easy method for predicting treatment response.
Article
Public, Environmental & Occupational Health
Anita Andreano, Maria Grazia Valsecchi, Antonio Giampiero Russo, Salvatore Siena
Summary: A set of 34 indicators for guideline-concordant care in lung cancer was selected and evaluated by a multidisciplinary panel of clinicians. Out of 22 feasible indicators, 16 were retained after assessing criterion validity and were further evaluated for reliability. The developed set of indicators is now available for implementing and monitoring quality initiatives for lung cancer care.
ARCHIVES OF PUBLIC HEALTH
(2021)