Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the γ-sarcoglycan-null mouse

(2016) Jessica C. de Greef et al.   HUMAN MOLECULAR GENETICS

Abnormal Skeletal Muscle Regeneration plus Mild Alterations in Mature Fiber Type Specification in Fktn-Deficient Dystroglycanopathy Muscular Dystrophy Mice

(2016) Steven J. Foltz et al.   PLoS One

Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy

(2016) Motoi Kanagawa et al.   Cell Reports

mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration

(2015) Pengpeng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy

(2015) Nicholas P. Whitehead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

(2015) Yao-Song Gui et al.   PLoS One

Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function

(2014) Kristin P. Bibee et al.   FASEB JOURNAL

Glycobiology of  -dystroglycan and muscular dystrophy

(2014) T. Endo   JOURNAL OF BIOCHEMISTRY

MicroRNA-486–dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy–associated symptoms

(2014) Matthew S. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

(2014) Michael Cardamone et al.   JOURNAL OF PEDIATRICS

Efficacy and Safety of Sirolimus for Renal Angiomyolipoma in Patients with Tuberous Sclerosis Complex or Sporadic Lymphangioleiomyomatosis: A Systematic Review

(2014) Zhu-feng Peng et al.   JOURNAL OF UROLOGY

Development of Rabbit Monoclonal Antibodies for Detection of Alpha-Dystroglycan in Normal and Dystrophic Tissue

(2014) Marisa J. Fortunato et al.   PLoS One

Strategies for the management of adverse events associated with mTOR inhibitors

(2014) Bruce Kaplan et al.   Transplantation Reviews

Rescue of dystrophic skeletal muscle by PGC-1α involves restored expression of dystrophin-associated protein complex components and satellite cell signaling

(2013) Katrin Hollinger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Dissecting the Molecular Basis of the Role of the O-Mannosylation Pathway in Disease: α-Dystroglycan and Forms of Muscular Dystrophy

(2013) David Live et al.   CHEMBIOCHEM

Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86

(2013) Mehmet Canpolat et al.   CHILDS NERVOUS SYSTEM

Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression

(2013) Motoi Kanagawa et al.   HUMAN MOLECULAR GENETICS

Acute failure of action potential conduction inmdxmuscle reveals new mechanism of contraction-induced force loss

(2013) Jarrod A. Call et al.   JOURNAL OF PHYSIOLOGY-LONDON

LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy

(2013) Matthew M. Goddeeris et al.   NATURE

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

(2012) Marion Pauly et al.   AMERICAN JOURNAL OF PATHOLOGY

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan

(2012) Jillian M. Rojek et al.   CELLULAR MICROBIOLOGY

Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration

(2012) Jamie L. Marshall et al.   JOURNAL OF CELL BIOLOGY

Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy

(2012) Aaron M. Beedle et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Defects in Glycosylation Impair Satellite Stem Cell Function and Niche Composition in the Muscles of the Dystrophic LargemydMouse

(2012) Jacob Ross et al.   STEM CELLS

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice

(2011) M. H. Kim et al.   HUMAN MOLECULAR GENETICS

TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR)

(2011) Anna Goc et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth

(2011) Craig A. Goodman et al.   JOURNAL OF PHYSIOLOGY-LONDON

O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling

(2011) A. J. Majmundar et al.   MOLECULAR AND CELLULAR BIOLOGY

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(2011) Saman Eghtesad et al.   MOLECULAR MEDICINE

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection

(2011) Y. Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles

(2010) Eva Masiero et al.   Autophagy

Fukutin-related protein is essential for mouse muscle, brain and eye development and mutation recapitulates the wide clinical spectrums of dystroglycanopathies

(2010) Yiumo Michael Chan et al.   HUMAN MOLECULAR GENETICS

Muscle regeneration occurs to coincide with mitochondrial biogenesis

(2010) Akira Wagatsuma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Progressive resistance voluntary wheel running in the mdx mouse

(2010) Jarrod A. Call et al.   MUSCLE & NERVE

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

(2010) Darcy A. Krueger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Necrosis Factor-α Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells

(2010) Shephali Bhatnagar et al.   PLoS One

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

(2009) Yejing Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of  -dystroglycan

(2009) R. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Myostatin Directly Regulates Skeletal Muscle Fibrosis

(2008) Zhao Bo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Lysosomal myopathies: An excessive build-up in autophagosomes is too much to handle

(2008) May Christine Malicdan et al.   NEUROMUSCULAR DISORDERS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL