Article
Medicine, General & Internal
Yan-zhong Han, Yu-ming Guo, Peng Xiong, Fei-lin Ge, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Hai-bo Song, Xiao-he Xiao, Jia-bo Wang
Summary: This study found that the aging population is more susceptible to liver-related ADRs, with the relative risk increasing exponentially with age. It is important to address risk management for older adults when using drugs with a high correlation to the risk of ADRs.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yuting Shan, Lee Cheung, Yuqi Zhou, Yingbo Huang, R. Stephanie Huang
Summary: This review summarizes the current knowledge on sex differences in adverse drug reactions (ADRs) of commonly used psychotropic, cardiovascular, and analgesic medications. The main findings suggest that more than half of the evaluated ADRs show a sex difference in occurrence rate, with some medications causing more adverse reactions in women and others in men.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Eleanor G. Dixon, Shaista Rasool, Brian Otaalo, Ashmika Motee, James W. Dear, Derek Sloan, Helen R. Stagg
Summary: Missed doses of anti-TB treatment are often caused by adverse drug reactions (ADRs), but the relative contribution of ADRs to missed doses and the patterns of missed doses due to ADRs have not been well-studied. This scoping review aims to address these knowledge gaps.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Pansakon Wattanachai, Warayuwadee Amornpinyo, Parinya Konyoung, Danklai Purimart, Usanee Khunarkornsiri, Oranuch Pattanacheewapull, Wichittra Tassaneeyakul, Nontaya Nakkam
Summary: This study extensively characterizes the associations between HLA genetic polymorphisms and several phenotypes of beta-lactam antibiotics-related severe cutaneous adverse reactions (SCARs).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Daria Schetz, Tara Elizabeth Scott, Wojciech Waldman, Jacek Sein Anand, Marek Wiergowski, Ivan Kocic
Summary: This study compares the incidence of adverse drug reactions (ADR) of antidepressive agents, benzodiazepines, and antipsychotics plus mood stabilizers (AaMS) in Poland and Australia during the COVID-19 pandemic and before. The results show a significant increase in ADR reports in Poland, with the highest increase seen in antidepressive agents. In Australia, there is a modest increase in ADR reports for antidepressive agents and a significant increase for benzodiazepines.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Caitriona Cahir, Carmel Curran, Caroline Walsh, Anne Hickey, Ross Brannigan, Ciara Kirke, David J. Williams, Kathleen Bennett
Summary: The study aimed to determine the prevalence and characteristics of ADR-related hospital admissions among older patients in Ireland and identify associated risk factors. The results showed that 10% of hospital admissions were ADR-related, with approximately 70% being potentially avoidable.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Fei-lin Ge, Ming Niu, Zi-xin Han, Jun-ling Cao, Jia-bo Wang, Zhao-fang Bai, Hai-bo Song, Yu-ming Guo, Xiao-he Xiao
Summary: The cases of hepatobiliary adverse drug reactions (ADR) related to BGZP showed an increasing trend year by year, partly due to irrational drug use. BGZP was mainly used for diseases caused by abnormal immune activation, and caution is recommended especially for female patients with immunological diseases.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Review
Medicine, General & Internal
Sarah Noetzlin, Gautier Breville, Joerg D. Seebach, Giacomo Gastaldi
Summary: This review discusses the wide range of potential side effects of short-term systemic glucocorticoid administration, particularly focusing on metabolic conditions and management of hyperglycemia.
SWISS MEDICAL WEEKLY
(2022)
Article
Geriatrics & Gerontology
Li-Ju Chen, Thi Ngoc Mai Nguyen, Dana Clarissa Laetsch, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Ben Schoettker
Summary: The study found that the quality of combined medication in older colorectal cancer patients is significantly associated with overall and CRC-specific survival, with potentially inappropriate medication use and overuse having negative impacts. The results suggest that improved cancer medication management in this patient population may prolong survival.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Infectious Diseases
Ewa Maria Sokolewicz, Martyna Rogowska, Milosz Lewandowski, Monika Puchowska, Dorota Piechota, Wioletta Baranska-Rybak
Summary: The study aimed to determine the prevalence of antibiotic-related dermatological adverse drug reactions in patients treated in a dermatology department in Poland from 2004 to 2021. Beta-lactam antibiotics were found to be the most common group causing skin reactions, with amoxicillin being the most frequently implicated.
Review
Biochemistry & Molecular Biology
Fumi Miyagawa, Hideo Asada
Summary: For severe cutaneous adverse reactions (SCARs) like Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS), analyzing distinct chemokine profiles can aid in their diagnosis and treatment. It is crucial to identify new therapeutic targets for SCARs, with chemokines playing a key role in the pathogenesis and adjuvant diagnosis of these conditions. Additionally, the association between human herpesvirus 6 (HHV-6) and DIHS/DRESS, as well as the possible roles of chemokine/chemokine receptor homologs encoded by HHV-6 in the pathogenesis, are areas of increasing interest.
Article
Public, Environmental & Occupational Health
Quentin Beytout, Nagisa Godefroy, Gentiane Monsel, Stephane Jaureguiberry, Eric Caumes
Summary: The prevalence of anti-tuberculosis related adverse cutaneous reactions is around 1%. The most frequent reactions are exanthema, followed by urticaria and drug rash with eosinophilia and systemic symptoms (DRESS). Sequential drug reintroduction can quickly identify the main culprit drug and achieve good outcomes. Rifampicin and pyrazinamide are the two most common culprit drugs, while ethambutol and rifampicin are associated with DRESS.
JOURNAL OF TRAVEL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ramon Cacabelos, Vinogran Naidoo, Lola Corzo, Natalia Cacabelos, Juan C. Carril
Summary: Pharmacogenomics plays a crucial role in optimizing drug efficacy and safety in preventing adverse drug reactions, but its application in ADR prevention is hindered by limitations such as lack of education and training, unspecific biomarkers, cost-effectiveness issues, administrative challenges, and insufficient regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Laura S. M. Kuula, Janne T. Backman, Marja L. Blom
Summary: The aim of this study was to estimate healthcare costs and mortality associated with serious fluoroquinolone-related adverse reactions in Finland from 2008 to 2019. Results showed that serious adverse reactions resulted in high healthcare costs and mortality risk, with severe clostridioides difficile infections being the most frequent, fatal, and costly adverse reactions.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Review
Pharmacology & Pharmacy
Abdelbaset A. Elzagallaai, Michael J. Rieder
Summary: In most cases, drug use in children is based on data extrapolated from trials in adult populations, which increases the risk of adverse drug reactions. Drug hypersensitivity reactions, a major type of ADR, are largely unpredictable and problematic due to a lack of understanding of their pathophysiology. The lack of clear clinical guidelines for children makes modeling a desirable approach to address this issue.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Urology & Nephrology
Yang Lu, Fan Tianyong, Han Ping, Liu Liangren, Yuan Haichao, Wei Qiang
JOURNAL OF UROLOGY
(2012)
Letter
Urology & Nephrology
Wenbin Xue, Lu Yang, Qiang Wei
JOURNAL OF UROLOGY
(2018)
Article
Engineering, Biomedical
Yaqi Qiu, Shi Qiu, Linghui Deng, Ling Nie, Lina Gong, Xinyang Liao, Xiaonan Zheng, Kun Jin, Jiakun Li, Xiang Tu, Liangren Liu, Zhenhua Liu, Yige Bao, Jianzhong Ai, Tianhai Lin, Lu Yang, Qiang Wei