Aberrant repair and fibrosis development in skeletal muscle

Relaxin Regulates MMP Expression and Promotes Satellite Cell Mobilization During Muscle Healing in Both Young and Aged Mice

(2010) Xiaodong Mu et al.   AMERICAN JOURNAL OF PATHOLOGY

A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway

(2010) Frédéric Trensz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sca-1 influences the innate immune response during skeletal muscle regeneration

(2010) Kimberly K. Long et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment

(2010) Carlo O. Martinez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Regulatory interactions between muscle and the immune system during muscle regeneration

(2010) James G. Tidball et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Microarchitecture Is Severely Compromised but Motor Protein Function Is Preserved in Dystrophic mdx Skeletal Muscle

(2010) O. Friedrich et al.   BIOPHYSICAL JOURNAL

Higher proportion of fast-twitch (type II) muscle fibres in idiopathic inflammatory myopathies - evident in chronic but not in untreated newly diagnosed patients

(2010) I. Loell et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Signaling pathways perturbing muscle mass

(2010) David J Glass   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Connective tissue fibroblasts and Tcf4 regulate myogenesis

(2010) S. J. Mathew et al.   DEVELOPMENT

Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: Effect on myotube fusion

(2010) Suzy Roffe et al.   EXPERIMENTAL CELL RESEARCH

Regulation and dysregulation of fibrosis in skeletal muscle

(2010) Antonio L. Serrano et al.   EXPERIMENTAL CELL RESEARCH

Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype

(2010) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

The role of nitric oxide during healing of trauma to the skeletal muscle

(2010) Lidiane Isabel Filippin et al.   INFLAMMATION RESEARCH

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Nitric oxide regulates the repair of injured skeletal muscle

(2010) Lidiane Isabel Filippin et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Role of matrix metalloproteinases in skeletal muscle

(2010) Xiaoping Chen et al.   Cell Adhesion & Migration

Imatinib and the Treatment of Fibrosis: Recent Trials and Tribulations

(2010) Jessica Gordon et al.   Current Rheumatology Reports

The impact of sarcopenia and exercise training on skeletal muscle satellite cells

(2009) Tim Snijders et al.   AGEING RESEARCH REVIEWS

Role of MKP-1 in Osteoclasts and Bone Homeostasis

(2009) Jodi Carlson et al.   AMERICAN JOURNAL OF PATHOLOGY

Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury

(2009) Madly Brigitte et al.   ARTHRITIS AND RHEUMATISM

Clinical Applications of Creatine Supplementation on Paediatrics

(2009) Athanasios Evangeliou et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

(2009) Andrew S. Brack et al.   DEVELOPMENTAL BIOLOGY

Imatinib attenuates skeletal muscle dystrophy in mdx mice

(2009) Ping Huang et al.   FASEB JOURNAL

Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy

(2009) H. Li et al.   HUMAN MOLECULAR GENETICS

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Latent TGF-β–binding protein 4 modifies muscular dystrophy in mice

(2009) Ahlke Heydemann et al.   JOURNAL OF CLINICAL INVESTIGATION

Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice

(2009) João Carlos da Silva Bizario et al.   JOURNAL OF NEUROIMMUNOLOGY

Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease

(2009) Louise R. Rodino-Klapac et al.   MUSCLE & NERVE

Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading

(2009) Anna E. Thalacker-Mercer et al.   PHYSIOLOGICAL GENOMICS

Clinical Heterogeneity of Duchenne Muscular Dystrophy (DMD): Definition of Sub-Phenotypes and Predictive Criteria by Long-Term Follow-Up

(2009) Isabelle Desguerre et al.   PLoS One

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Matrix metalloproteinase-1 treatment of muscle fibrosis

(2008) Joel L. Kaar et al.   Acta Biomaterialia

Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone

(2008) Kyla D. Huebner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II Receptor Blockade Administered after Injury Improves Muscle Regeneration and Decreases Fibrosis in Normal Skeletal Muscle

(2008) Hany S. Bedair et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

(2008) James G. Ryall et al.   BIOGERONTOLOGY

Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration

(2008) Kimberly A. Kafadar et al.   DEVELOPMENTAL BIOLOGY

Dual and Beneficial Roles of Macrophages During Skeletal Muscle Regeneration

(2008) Bénédicte Chazaud et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis

(2008) M SEGAWA et al.   EXPERIMENTAL CELL RESEARCH

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

Skeletal Muscle Diseases, Inflammation, and NF-κB Signaling: Insights and Opportunities for Therapeutic Intervention

(2008) Jennifer M. Peterson et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Myostatin Directly Regulates Skeletal Muscle Fibrosis

(2008) Zhao Bo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Context matters: In vivo and in vitro influences on muscle satellite cell activity

(2008) D.D.W. Cornelison   JOURNAL OF CELLULAR BIOCHEMISTRY

Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy

(2008) Enrique Brandan et al.   MATRIX BIOLOGY

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

PlGF–MMP-9–expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle

(2008) Cesare Gargioli et al.   NATURE MEDICINE

Reduced muscle necrosis and long-term benefits in dystrophic mdx mice after cV1q (blockade of TNF) treatment

(2008) Hannah G. Radley et al.   NEUROMUSCULAR DISORDERS

Premature Aging in Skeletal Muscle Lacking Serum Response Factor

(2008) Charlotte Lahoute et al.   PLoS One

Exercise-Induced Activation of STAT3 Signaling Is Increased with Age

(2008) Marissa K. Trenerry et al.   REJUVENATION RESEARCH

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

(2007) Cecilia Vial et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES