Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells

A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case

(2015) Liang-Chin Huang et al.   BMC Systems Biology

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

(2015) M. E. M. Dolman et al.   CLINICAL CANCER RESEARCH

Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

(2014) Alexandra Eder et al.   BASIC RESEARCH IN CARDIOLOGY

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption

(2014) Chan Kim et al.   CANCER CELL

Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

(2014) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

In silico identification of potential targets and drugs for non-small cell lung cancer

(2014) Chien-Hung Huang et al.   IET Systems Biology

N-cadherin, A Vascular Smooth Muscle Cell-Cell Adhesion Molecule: Function and Signaling for Vasomotor Control

(2014) Zhe Sun et al.   MICROCIRCULATION

Current Opinions on the Control and Role of Vascular Smooth Muscle Cell Adhesion, Calcium Sensitization, and the Cytoskeleton in Vascular Structure and Function

(2014) Luis A. Martinez-Lemus   MICROCIRCULATION

High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan

(2013) Hanna Dellago et al.   AGING CELL

The calmodulin inhibitor and antipsychotic drug trifluoperazine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells

(2013) Da Hye Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the Ubiquitin Proteasome System in the Heart

(2013) Julia Pagan et al.   CIRCULATION RESEARCH

SBEToolbox: A Matlab Toolbox for Biological Network Analysis

(2013) Kranti Konganti et al.   Evolutionary Bioinformatics

High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through the ERK 1/2-dependent pathway

(2013) Gang Liu et al.   HYPERTENSION RESEARCH

Deregulation of smooth muscle cell cytoskeleton within the human atherosclerotic coronary media layer

(2013) Fernando de la Cuesta et al.   Journal of Proteomics

Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding

(2013) J. Qiu et al.   Journal of the Royal Society Interface

Network-based drug repositioning

(2013) Zikai Wu et al.   Molecular BioSystems

An Anthelmintic Drug, Pyrvinium Pamoate, Thwarts Fibrosis and Ameliorates Myocardial Contractile Dysfunction in a Mouse Model of Myocardial Infarction

(2013) Motoaki Murakoshi et al.   PLoS One

P2X1 receptor-mediated inhibition of the proliferation of human coronary smooth muscle cells involving the transcription factor NR4A1

(2013) Annette Viktoria Hinze et al.   Purinergic Signalling

Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks

(2013) Shao-Yan Sun et al.   Scientific Reports

Joint conditional Gaussian graphical models with multiple sources of genomic data

(2013) Hyonho Chun et al.   Frontiers in Genetics

Trichostatin A Ameliorates Myocardial Ischemia/Reperfusion Injury Through Inhibition of Endoplasmic Reticulum Stress-induced Apoptosis

(2012) Ling Yu et al.   ARCHIVES OF MEDICAL RESEARCH

Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling

(2012) Dong Ju Son et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Physiological and pathological role of the ubiquitin-proteasome system in the vascular smooth muscle cell

(2012) M. Demasi et al.   CARDIOVASCULAR RESEARCH

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis

(2012) K. S. Mascall et al.   JOURNAL OF CELL SCIENCE

The Effect of Pressure-Induced Mechanical Stretch on Vascular Wall Differential Gene Expression

(2012) M.A. Anwar et al.   JOURNAL OF VASCULAR RESEARCH

Detecting overlapping protein complexes in protein-protein interaction networks

(2012) Tamás Nepusz et al.   NATURE METHODS

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms

(2012) Matthew R. Alexander et al.   PHYSIOLOGICAL GENOMICS

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo

(2012) Azariyas A. Challa et al.   PLoS One

Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts

(2011) Zhong-Dong Shi et al.   ANNALS OF BIOMEDICAL ENGINEERING

Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells

(2011) Yang Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of peroxisome-proliferator-activated receptors α and γ mediates remote ischemic preconditioning against myocardial infarction in vivo

(2011) Christopher Lotz et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Low-Density Lipoproteins Induce Heat Shock Protein 27 Dephosphorylation, Oligomerization, and Subcellular Relocalization in Human Vascular Smooth Muscle Cells

(2010) Maísa García-Arguinzonis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Zyxin Mediation of Stretch-Induced Gene Expression in Human Endothelial Cells

(2010) Agnieszka Wójtowicz et al.   CIRCULATION RESEARCH

The Mechanical Stress–Activated Serum-, Glucocorticoid-Regulated Kinase 1 Contributes to Neointima Formation in Vein Grafts

(2010) Jizhong Cheng et al.   CIRCULATION RESEARCH

Sent to Destroy

(2010) Monte S. Willis et al.   CIRCULATION RESEARCH

The Amiloride Derivative Phenamil Attenuates Pulmonary Vascular Remodeling by Activating NFAT and the Bone Morphogenetic Protein Signaling Pathway

(2010) M. C. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

From NPC Therapeutic Target Identification to Potential Treatment Strategy

(2010) M.-Y. Lan et al.   MOLECULAR CANCER THERAPEUTICS

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1

(2009) Zhong-Dong Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effect of a peroxisome proliferator-activated receptor γ sumoylation mutant on neointimal formation after balloon injury in rats

(2009) Soo Lim et al.   ATHEROSCLEROSIS

Disruption of actin cytoskeleton mediates loss of tensile stress induced early phenotypic modulation of vascular smooth muscle cells in organ culture

(2009) Jian-Pu Zheng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids

(2009) Mohamad Navab et al.   JOURNAL OF LIPID RESEARCH

Extracellular matrix alterations in hypertensive vascular remodeling

(2009) Catherine A. Lemarié et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modulating the Functional Contributions of c-Myc to the Human Endothelial Cell Cyclic Strain Response

(2009) Nicole E. Hurley et al.   JOURNAL OF VASCULAR RESEARCH

Parthenolide inhibits proliferation of vascular smooth muscle cells through induction of G0/G1 phase cell cycle arrest

(2009) Shao-xiang Weng et al.   Journal of Zhejiang University-SCIENCE B

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells

(2008) Margherita Mutarelli et al.   BMC BIOINFORMATICS

Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells

(2008) Muyao Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway

(2008) Tamara N. Fitzgerald et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

(2008) Paul G. Wyatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms in Experimental Venous Valve Failure and their Modification by Daflon© 500 mg

(2007) L. Pascarella et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY