Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes

Induction of Angiogenesis by a Type III Phosphodiesterase Inhibitor, Cilostazol, Through Activation of Peroxisome Proliferator-Activated Receptor-γ and cAMP Pathways in Vascular CellsSignificance

(2016) Fumihiro Sanada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration

(2016) Nathan G. Lambert et al.   EXPERIMENTAL EYE RESEARCH

Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy

(2016) Luigi Di Luigi et al.   INFLAMMATION

PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial

(2016) Daniela Fiore et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interleukin-19 and angiopoietin-2 can enhance angiogenesis of diabetic complications

(2016) Li Li et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Association between interleukin-19 and angiopoietin-2 with vascular complications in type 2 diabetes

(2016) Li Li et al.   Journal of Diabetes Investigation

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury

(2016) Eva Rübig et al.   Scientific Reports

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

(2015) Judd M. Cahoon et al.   DIABETES

Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes

(2015) Ele Ferrannini et al.   EUROPEAN HEART JOURNAL

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes

(2015) Elisabetta Mandosi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Serum angiopoietin-2 is associated with angiopathy in type 2 diabetes mellitus

(2015) Li Li et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Tumor Necrosis Factor-Alpha and 8-Hydroxy-2'-Deoxyguanosine are Associated with Elevated Urinary Angiopoietin-2 Level in Type 2 Diabetic Patients with Albuminuria

(2015) Fang-Fang He et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin Dysbalance

(2015) Meriem Khairoun et al.   PLoS One

Urinary Angiopoietin-2 Is Associated with Albuminuria in Patients with Type 2 Diabetes Mellitus

(2015) Shan Chen et al.   International Journal of Endocrinology

Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse

(2015) Ji-Kan Ryu et al.   Scientific Reports

A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner

(2015) Nuri Oh et al.   Scientific Reports

Phosphodiesterase type 5 inhibitors: back and forward from cardiac indications

(2015) C. Corinaldesi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Everything you ever wanted to know about phosphodiesterase 5 inhibitors and the heart (but never dared ask): How do they work?

(2015) R. Pofi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Sildenafil Ameliorates Long Term Peripheral Neuropathy in Type II Diabetic Mice

(2015) Lei Wang et al.   PLoS One

Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice

(2015) Mary Anna Venneri et al.   PLoS One

Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials

(2014) Elisa Giannetta et al.   BMC Medicine

Therapeutic Effect of Alprostadil in Diabetic Nephropathy: Possible Roles of Angiopoietin-2 and IL-18

(2014) Changqing Luo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse

(2014) Guo Nan Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence

(2014) Jonathan Golledge et al.   STROKE

Oscillating high glucose enhances oxidative stress and apoptosis in human coronary artery endothelial cells

(2014) Ting-song Liu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

(2013) Andrey Anisimov et al.   CIRCULATION

Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation

(2013) Carlos Gonzalez-Quesada et al.   CIRCULATION RESEARCH

Is Glucose Control Important for Prevention of Cardiovascular Disease in Diabetes?

(2013) E. Mannucci et al.   DIABETES CARE

COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model

(2013) Sun-Ouck Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Targeted Glomerular Angiopoietin-1 Therapy for Early Diabetic Kidney Disease

(2013) C. Dessapt-Baradez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease

(2013) Fan-Chi Chang et al.   PLoS One

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

(2012) Karl H. Plate et al.   ACTA NEUROPATHOLOGICA

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy

(2012) Sirpa Loukovaara et al.   ACTA OPHTHALMOLOGICA

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

(2012) Elisa Giannetta et al.   CIRCULATION

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained Improvement in Perfusion and Flow Reserve After Temporally Separated Delivery of Vascular Endothelial Growth Factor and Angiopoietin-1 Plasmid Deoxyribonucleic Acid

(2012) Alexandra H. Smith et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

COMP-Angiopoietin-1 Recovers Molecular Biomarkers of Neuropathy and Improves Vascularisation in Sciatic Nerve of ob/ob Mice

(2012) Joanna Kosacka et al.   PLoS One

Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model

(2011) Jian-Xiong Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A nanobiohybrid complex of recombinant baculovirus and Tat/DNA nanoparticles for delivery of Ang-1 transgene in myocardial infarction therapy

(2011) Arghya Paul et al.   BIOMATERIALS

Circulating Angiopoietins-1 and -2, Angiopoietin Receptor Tie-2 and Vascular Endothelial Growth Factor-A as Biomarkers of Acute Myocardial Infarction: a Prospective Nested Case-Control Study

(2011) Carlos Iribarren et al.   BMC Cardiovascular Disorders

Abnormal regulation of neo-vascularisation in deep partial thickness scalds in rats with diabetes mellitus

(2011) Liang Qiao et al.   BURNS

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study

(2011) Sazan Rasul et al.   Cardiovascular Diabetology

Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth

(2011) H. Huang et al.   CLINICAL CANCER RESEARCH

Intracavernous Delivery of a Designed Angiopoietin-1 Variant Rescues Erectile Function by Enhancing Endothelial Regeneration in the Streptozotocin-Induced Diabetic Mouse

(2011) Hai-Rong Jin et al.   DIABETES

Mitotic and antiapoptotic effects of nanoparticles coencapsulating human VEGF and human angiopoietin-1 on vascular endothelial cells

(2011) Satya Prakash et al.   International Journal of Nanomedicine

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

(2011) Marie Jeansson et al.   JOURNAL OF CLINICAL INVESTIGATION

A Human Neutralizing Antibody Specific to Ang-2 Inhibits Ocular Angiogenesis

(2011) EMMA S. RENNEL et al.   MICROCIRCULATION

Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke

(2011) Xu Cui et al.   NEUROBIOLOGY OF DISEASE

Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition

(2010) Qin-hui Tuo et al.   ACTA PHARMACOLOGICA SINICA

Combination of Injectable Multiple Growth Factor–Releasing Scaffolds and Cell Therapy as an Advanced Modality to Enhance Tissue Neovascularization

(2010) Jaimy Saif et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Clinical and Genetic Correlates of Circulating Angiopoietin-2 and Soluble Tie-2 in the Community

(2010) Wolfgang Lieb et al.   Circulation-Cardiovascular Genetics

A Mouse Model of Cavernous Nerve Injury-Induced Erectile Dysfunction: Functional and Morphological Characterization of the Corpus Cavernosum

(2010) Hai-Rong Jin et al.   Journal of Sexual Medicine

High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1

(2010) Harprit Singh et al.   MICROVASCULAR RESEARCH

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

(2010) J. L. Brown et al.   MOLECULAR CANCER THERAPEUTICS

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia

(2009) Frederick Pfister et al.   ACTA DIABETOLOGICA

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

(2009) Beverly L. Falcón et al.   AMERICAN JOURNAL OF PATHOLOGY

COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice

(2009) Hoon Ki Sung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Scaffolds with covalently immobilized VEGF and Angiopoietin-1 for vascularization of engineered tissues

(2009) Loraine L.Y. Chiu et al.   BIOMATERIALS

COMP-Angiopoietin-1 ameliorates surgery-induced ischemic necrosis of the femoral head in rats

(2009) Byung-Hyun Park et al.   BONE

Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment

(2009) T. Holopainen et al.   CANCER RESEARCH

Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats

(2009) S. M. Samuel et al.   DIABETES

Protective role of COMP-Ang1 in ischemic rat brain

(2009) Hye Young Shin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

(2009) Duk Hoon Kim et al.   KIDNEY INTERNATIONAL

Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study–74)

(2009) Sathish Anuradha et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice

(2008) Jian-Xiong Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1  (HIF-1 )-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1  Expression, and Normalizes Immature Vasculature in db/db Mice

(2008) J.-X. Chen et al.   DIABETES

Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury

(2008) So Ri Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart

(2008) Hua Su et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Acceleration of Diabetic Wound Healing by an Angiopoietin Peptide Mimetic

(2008) Paul Van Slyke et al.   TISSUE ENGINEERING PART A