Review
Biochemistry & Molecular Biology
Aijun Xie, Shanshan Zhao, Zifei Liu, Xiqing Yue, Junhua Shao, Mohan Li, Zhiwei Li
Summary: Probiotics have various benefits for humans, but their viability may be reduced during storage and digestion. Microencapsulation techniques, specifically using polysaccharides and proteins, can improve the stability and targeted release of probiotics. This study summarizes the applications and evolution of microencapsulation technologies for probiotics, discussing their benefits, limitations, and suggesting future research directions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Lionel Galibert, Aurelien Jacob, Adrien Savy, Yohann Dickx, Delphine Bonnin, Christophe Lecomte, Lise Rivollet, Peggy Sanatine, Marjorie Boutin Fontaine, Christine Le Bec, Otto-Wilhelm Merten
Summary: Large-scale manufacturing of rAAV remains a challenge, with the Monobac system showing higher yields of rAAV vectors and lower DNA contamination compared to dual baculovirus systems.
Article
Chemistry, Medicinal
Sabrina Schaly, Paromita Islam, Ahmed Abosalha, Jacqueline L. Boyajian, Dominique Shum-Tim, Satya Prakash
Summary: This study demonstrates that encapsulating a recombinant baculovirus expressing VEGFA in chitosan-coated alginate hydrogels enhances cell migration, angiogenesis, and wound healing, while also providing antimicrobial properties and sustained delivery of the virus.
Article
Cardiac & Cardiovascular Systems
N. Fairooj Rashid, E. Zoe Clayton, Masahito Ogawa, Jose Perdomo, D. Robert Hume, Eddy Kizana, J. H. James Chong
Summary: Overexpression of Pdgf-a in the post-MI heart can modulate scar composition and improve left ventricular function, highlighting the potential of rAAV gene transfer of Pdgf-a as a cardio-reparative therapy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bruna C. Leopercio, Mariano Michelon, Marcio S. Carvalho
Summary: This study experimentally investigates the flow of monodispersed gellan gum microcapsules through a constricted capillary tube by measuring the evolution of pressure difference and flow visualization. The maximum pressure difference and capsule deformation for capsules with different diameter and shell thickness were obtained. Mapping the conditions at which the capsule membrane ruptures during the flow and releases its internal phase was also conducted.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Srisan Phupaboon, Maharach Matra, Ronnachai Prommachart, Pajaree Totakul, Chanadol Supapong, Metha Wanapat
Summary: The objective of this research was to study the bioactive compounds of herbal plant leaves through microencapsulation technique and explore their potential application as feed additives. Three herbal plants, namely Cannabis sativa L., Cannabis indica L., and Mitragyna speiosa K., were investigated using different methods to extract their bioactive compounds. Microwave extraction yielded higher total polyphenolic and flavonoid contents and stronger antioxidant capacity compared to maceration extraction. The extracted compounds were then encapsulated with chitosan through spray-drying, resulting in improved recovery with high encapsulation efficiency.
Article
Biophysics
Madhurima Mandal, Indranil Banerjee, Mahitosh Mandal
Summary: Nanoparticulate delivery systems have revolutionized cancer treatment, but their application in gene therapy is still in its early stages. This review article focuses on the use of nanoparticle-mediated gene therapy in retinoblastoma treatment and discusses future research directions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Sumaira Miskeen, Young Sik An, Jong-Yea Kim
Summary: In this study, curcumin was encapsulated in citric acid-modified starch nanoparticles, exhibiting amorphous encapsulation within the composite and hydrogen bond formation between nanoparticles and curcumin as a major driving force for encapsulation. Encapsulation significantly enhanced UV, pH, and thermal stability of curcumin, with release mechanism following the Korsmeyer-Peppas model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Naiara Hennig Neuenfeldt, Debora Piovesan de Moraes, Cassandra de Deus, Milene Teixeira Barcia, Cristiano Ragagnin de Menezes
Summary: Blueberries are a significant source of bioactive compounds, particularly phenolic compounds such as anthocyanins. However, these compounds are sensitive to environmental factors and can be unstable. Microencapsulation has been shown to be an effective method for improving the stability and bioavailability of anthocyanins.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Food Science & Technology
Juliana Domingues dos Santos Carvalho, Vivian Boesso Oriani, Glazieli Marangoni de Oliveira, Miriam Dupas Hubinger
Summary: This study investigated the stability of solid lipid microparticles loaded with ascorbic acid under thermal cyclization conditions. The results showed that the particles were stable during the 45 days of storage, with controlled release and retention rates ranging from 74.25% to 83.07%. The polymorphic analysis revealed that beta' crystals were predominant in all formulations studied.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Review
Pharmacology & Pharmacy
Prerak Gupta, Omar Alheib, Jae -Won Shin
Summary: The primary purpose of therapeutic cell encapsulation is to broaden donor cell options and provide compromised physiological cues. Advances in biomaterial design allow for more precise control of cellular phenotypes and single cell encapsulation materials for precise control of donor cells.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Prerak Gupta, Omar Alheib, Jae-Won Shin
Summary: The therapeutic cell encapsulation technique aims to expand the options for donor cell sources and provide physiologically relevant cues for improved control of donor cells.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Food Science & Technology
Uzma Sadiq, Harsharn Gill, Jayani Chandrapala
Summary: Casein micelles have emerged as a promising technology for delivering bioactive food components due to their hydrophobic and hydrophilic properties, self-assembling nature, remarkable surface activity, and pH swelling behavior, which enable targeted and controlled release in the gastrointestinal tract. However, further comprehensive studies are needed to understand how variations in their structural properties can be utilized for delivering bioactives with different properties.
Article
Food Science & Technology
Tonghui Liu, Chuqi Feng, Zhaofeng Li, Zhengbiao Gu, Xiaofeng Ban, Yan Hong, Li Cheng, Caiming Li
Summary: This study focused on encapsulating carvacrol with mixed cyclodextrins to improve its stability and release effectiveness. Microencapsulated carvacrol showed better encapsulation efficiency and release performance, offering new possibilities for its applications in the food and pharmaceutical industries.
Article
Food Science & Technology
Xiao Wang, Zhuang Ding, Yanna Zhao, Sangeeta Prakash, Wenlai Liu, Jun Han, Zhengping Wang
Summary: This study investigated the effects of emulsion preparation on the quality of lutein microencapsulated powder (LMPs). It was found that LMPs with nano-sized particles exhibited higher encapsulation efficiency, storage stability, and dissolution rate.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Arghya Paul
Article
Polymer Science
Sayantani Basu, Rea Johl, Settimio Pacelli, Stevin Gehrke, Arghya Paul
Article
Engineering, Biomedical
Settimio Pacelli, Aparna R. Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A. Neal, Adam J. Mellott, Aishik Chakraborty, Arghya Paul
Summary: The study utilized polydopamine (pDA) treatment as a binding platform to create a versatile gelatin-alginate (Gel-Alg) hydrogel, effectively controlling stem cell adhesion and osteogenic differentiation, demonstrating the potential application value in tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Cynthia Elias, Arghya Paul
Summary: Vaccines have been essential in training the immune system, but face challenges in manufacturing, large-scale production, and storage, with some showing suboptimal immunogenicity. A new class of biomimetic materials has emerged as an alternative vaccination strategy.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Cho-E Choi, Aishik Chakraborty, Ali Coyle, Yasmeen Shamiya, Arghya Paul
Summary: Considerable progress has been made in synthesizing intelligent, biodegradable hydrogels that undergo rapid changes in physicochemical properties once exposed to external stimuli. These advantageous properties of stimulus-triggered materials make them highly appealing to diverse biomedical applications. Of late, research on the incorporation of light-triggered nanoparticles (NPs) into polymeric hydrogel networks has gained momentum due to their ability to remotely tune hydrogel properties using facile, contact-free approaches, such as adjustment of wavelength and intensity of light source.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Harshavardhan Budharaju, Allen Zennifer, Swaminathan Sethuraman, Arghya Paul, Dhakshinamoorthy Sundaramurthi
Summary: DNA, with its outstanding features such as functional molecular recognition motifs and high precision molecular self-assembly, has emerged as a leading biomaterial for 3D bioprinting and other biomedical applications. Researchers are continuously exploring the interesting properties of DNA for various applications, including cell-laden tissue constructs. Advanced design approaches and cost-effective production methods have further enhanced the versatility and potential of DNA in bioprinting.
MATERIALS HORIZONS
(2022)
Article
Medicine, Research & Experimental
Aishik Chakraborty, Settimio Pacelli, Shana Alexander, Sebastian Huayamares, Zachary Rosenkrans, Filippo Elmi Vergel, Yuanyi Wu, Adrija Chakravorty, Arghya Paul
Summary: A mechanically tough nanocomposite hydrogel was prepared by utilizing the electrostatic interaction between nanosilicates and gelatin methacrylate. This hydrogel showed slower degradation rate and sustained release of the encapsulated drug metformin. The nanocomposite material also exhibited cell protective effects in vitro.
MOLECULAR PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Ali Coyle, Alap Ali Zahid, Jin Wang, Michael S. H. Boutilier, Emmanuel A. Ho, Arghya Paul
Summary: In this study, a biomimetic cell-derived nanoparticle (CDN) loaded with Dexamethasone was developed, which showed efficient cellular uptake and stem cell differentiation. These CDNs exhibited good cytocompatibility and stability, making them suitable for bone regeneration applications.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Ali Coyle, Arghya Paul
Summary: Biobased nanoparticles are promising tools for biomedical research, but their commercial application has not been fully realized. In this perspective, advanced designs of biobased nanoparticles, such as cell membrane nanoparticles, exosomes, and synthetic lipid-derived nanoparticles, are discussed along with their benefits and potential challenges. The future use of artificial intelligence and machine learning in preparing these particles is also critically assessed. This field of research has the potential to greatly impact the rational design of drug transporters and improve therapeutic outcomes.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Alap Ali Zahid, Aishik Chakraborty, Yasmeen Shamiya, Shruthi Polla Ravi, Arghya Paul
Summary: Exploring new avenues for clinical management of chronic wounds is crucial for eliminating socioeconomic burdens and health concerns. Engineered biomaterials with improved functionalities, such as bioadhesiveness, antimicrobial properties, proangiogenic attributes, and anti-inflammatory properties, have been developed to enhance wound healing. Different biomaterial templates, including hydrogels, cryogels, nanomaterials, and biomolecule-functionalized materials, have been utilized to fabricate smart patches, microneedles, electrospun scaffolds, and 3D-bioprinted structures, enabling effective wound healing.
MATERIALS HORIZONS
(2022)
Article
Materials Science, Multidisciplinary
Sayantani Basu, Aishik Chakraborty, Abdul-Rahman Imad Alkiswani, Yasmeen Shamiya, Arghya Paul
Summary: In this study, mechanically tough nanocomposite hydrogels were prepared using natural polymer DNA and two-dimensional nanosheets of WS2. The formation of double network polymeric hydrogels significantly improved the mechanical properties of the hydrogels, while maintaining biocompatibility. These tough DNA-based hydrogels have the potential for various biomedical applications, including drug delivery of proteins and growth factors.
MATERIALS ADVANCES
(2022)
Review
Materials Science, Biomaterials
Aishik Chakraborty, Avinava Roy, Shruthi Polla Ravi, Arghya Paul
Summary: The use of nanoparticles in 3D bioprinting can enhance the mechanical properties, introduce new functionalities, and provide responsiveness to external stimuli in hydrogel-based bioinks. This approach allows for the creation of intricate biostructures, bringing the field of bioprinting closer to printing complex tissue structures and organs.
BIOMATERIALS SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Aishik Chakraborty, Shruthi Polla Ravi, Yasmeen Shamiya, Caroline Cui, Arghya Paul
Summary: Apart from its role as a genetic material, DNA can also be utilized to construct materials with desired properties, such as hydrogels. Current chemical tools and strategies are being employed to harness the non-genetic functions of DNA.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Aparna R. Chakravarti, Settimio Pacelli, Arghya Paul
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
