Article
Engineering, Biomedical
Vertika Pathak, Teresa Nolte, Elena Rama, Anne Rix, Seyed Mohammadali Dadfar, Vera Paefgen, Srinivas Banala, Eva Miriam Buhl, Marek Weiler, Volkmar Schulz, Twan Lammers, Fabian Kiessling
Summary: This study investigated the use of microbubbles containing superparamagnetic iron oxide nanoparticles as molecular MRI contrast agents targeted against angiogenesis in breast cancer. Results indicated that RGD-SPION-MB showed higher retention in angiogenic vessels compared to SPION-MB and RAD-SPION-MB, demonstrating their potential as effective molecular MR/US contrast agents for assessing integrin expression in neovasculature.
Article
Pharmacology & Pharmacy
Yun Liu, Zhiwei Zheng, Jiaxuan Han, Chen Lin, Chaoqi Liu, Yao Ma, Yun Zhao
Summary: In this study, the inhibitory effect of targeted CD133-loaded sPD1 gene microbubbles (MBs) combined with low-frequency ultrasound on cervical cancer was explored. The researchers prepared microbubbles conjugated with anti-CD133 antibody to deliver the sPD1 gene and determined the characteristics of the MBs. They found that CD133 targeted-MBs could specifically bind to cervical cancer cells in vitro. In a mouse model of subcutaneous cervical cancer, the CD133/sPD1-MBs group showed the strongest inhibitory effect on tumor growth. The combination of ultrasound with CD133-targeted microbubbles loaded with the sPD1 gene can improve the tumor's immunosuppressive microenvironment.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Marie-Solenne Felix, Emilie Borloz, Khaled Metwally, Ambre Dauba, Benoit Larrat, Valerie Matagne, Yann Ehinger, Laurent Villard, Anthony Novell, Serge Mensah, Jean-Christophe Roux
Summary: Gene therapy is a powerful tool for treating diseased tissues and providing lasting and effective correction. The combination of focused ultrasound and microbubbles appears to be a technological breakthrough for delivering therapeutic agents to the central nervous system.
Article
Oncology
Chanjuan Peng, Yong Wu, Yang Yang, Ningning Li, Xi Chen, Linhui Gu, Dong Xu, Chen Yang
Summary: The study demonstrated the enhanced destructive effect of UTMD combined with 4 Gy radiotherapy on glioblastoma, likely achieved through increased ability of DNA damage of tumor cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Engineering, Biomedical
Xionghai Qin, Peian Cai, Chang Liu, Kegong Chen, Xingpei Jiang, Wei Chen, Jiarou Li, Xuan Jiao, Erliang Guo, Yixiu Yu, Lu Sun, Hai Tian
Summary: Pathological cardiac hypertrophy is a critical precursor of heart failure, and effective treatments are needed. This study demonstrated the potential of ultrasound-targeted microbubble destruction (UTMD) as a delivery method for Sirt3 in hypertrophic heart tissues. Overexpression of Sirt3 ameliorated oxidative stress, improved diastolic function, and prevented apoptosis and fibrotic response.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Benjamin van Elburg, Joke Deprez, Martin van den Broek, Stefaan C. De Smedt, Michel Versluis, Guillaume Lajoinie, Ine Lentacker, Tim Segers
Summary: Sonoporation is a process facilitated by ultrasound-driven microbubble oscillations that enhances intracellular drug delivery. This study aimed to investigate the role of microbubble size on sonoporation and the relevant mechanism(s). The results showed that sonoporation efficiency strongly depended on the equilibrium bubble size, with bubbles of approximately 4.7 μm radius being the most efficient. Shear stress was unlikely to be the mechanism of action, while normal stress correlated well with sonoporation efficiency.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Liang Gui, Youlu Chen, Yongpeng Diao, Zuoguan Chen, Jianwei Duan, Xiaoyu Liang, Huiyang Li, Kaijing Liu, Yuqing Miao, Qing Gao, Zhichao Li, Jing Yang, Yongjun Li
Summary: This study introduces a nanoparticle-based gene delivery system using CYP2J2 and EETs for the treatment of CLI, with demonstrated potential in angiogenesis promotion, biocompatibility, high transfection efficiency, and VEGF expression.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Physical
Lingling Xu, Yihan Chen, Qiaofeng Jin, Tang Gao, Cheng Deng, Rui Wang, Yihui Wang, Ying Bai, Jia Xu, Wenqian Wu, He Li, Lingyun Fang, Jing Wang, Yali Yang, Li Zhang, Qing Lv, Mingxing Xie
Summary: A platelet membrane-coated nanoparticle (B-P@PLT) with an ultrasound-responsive nitric oxide (NO) donor is developed for targeted treatment of myocardial ischemia reperfusion injury (MIRI). B-P@PLT can specifically target the ischemic myocardium and release NO during ultrasound irradiation, increasing the local concentration of NO. B-P@PLT + US shows promising results in promoting angiogenesis, reducing reactive oxygen species production, and protecting cardiomyocytes in vitro and in vivo, improving heart function in MIRI.
Article
Pharmacology & Pharmacy
Stephanie He, Davindra Singh, Hossein Yusefi, Brandon Helfield
Summary: This study investigates the feasibility of delivering the angiogenesis-promoting miR-126 using ultrasound-stimulated microbubbles. The results show that by stimulating miR-126-decorated microbubbles, the intracellular levels of miR-126 can be increased while decreasing the expression of its target genes. This delivery method has the potential to stimulate therapeutic angiogenesis while minimizing endothelial damage.
Article
Pharmacology & Pharmacy
Yingying Liu, Xiaoshu Lai, Yao Zhu, Fengjuan Guo, Lili Su, Gulzira Arkin, Tianzhen He, Jinfeng Xu, Haitao Ran
Summary: In this study, a novel cationic magnetic microbubble (MBM) was developed, which could achieve targeted aggregation under a magnetic field and real-time visualization using ultrasound. These microbubbles had good biocompatibility, enhanced ultrasound contrast, and could accumulate in the target site through magnetic targeting.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Chao Zhang, Shuyuan Chen, Qunying Li, Jiao Wu, Fuqiang Qiu, Zhiyi Chen, Yang Sun, Jieli Luo, Raul A. Bastarrachea, Paul A. Grayburn, Ralph A. DeFronzo, Yajing Liu, Kun Qian, Pintong Huang
Summary: The study demonstrated successful gene delivery of GLP-1 in macaques using UTMD, leading to enhanced GLP-1 expression and improvement in pancreatic beta cell regeneration and plasma glucose regulation. This approach shows promising alternatives for treating type 2 diabetes.
Review
Medicine, Research & Experimental
Frederic Padilla, Jacqueline Brenner, Francesco Prada, Alexander L. Klibanov
Summary: Ultrasound-triggered microbubbles destruction can lead to vascular shutdown and has shown potential in preclinical studies for tumor growth delay, lesion formation, radio-sensitization, and modulation of the immune micro-environment. Antivascular ultrasound has the potential to be a focal, targeted, non-invasive, mechanical, and non-thermal treatment either alone or in combination with other therapies. The main mechanism behind these effects is believed to be cavitation, with both non-inertial and inertial cavitation playing significant roles.
Article
Hematology
Jiayuan Zhong, Yili Sun, Yuan Han, Xiaoqiang Chen, Hairui Li, Yusheng Ma, Yanxian Lai, Guoquan Wei, Xiang He, Mengsha Li, Wangjun Liao, Yulin Liao, Shiping Cao, Jianping Bin
Summary: The study confirmed that hs-Mbs+US treatment can effectively dissolve both white and red thrombi and alleviate skeletal muscle IRI through US-triggered, organ-specific release of H2S. This integrated therapeutic strategy holds promise for treating thromboembolic diseases and subsequent IRI.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Acoustics
Cong Li, Suling Hu, Yan Yue
Summary: This study investigated the effect of ultrasound microbubble-mediated VHL on ovarian cancer cells, revealing enhanced VHL expression, inhibited proliferation and migration, promoted apoptosis, and altered expression of proteins associated with cellular functions. Ultrasound microbubble technology increased VHL transfection efficiency and enhanced its biological impact on ovarian cancer cells.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zheng Zhang, Xiaoyan Miao, Weifeng Yao, Jie Ren, Chaojin Chen, Xiang Li, Jing Yang, Yujia You, Yuejun Lin, Tinghui Yin, Ziqing Hei
Summary: This study successfully developed a non-invasive, highly accurate, and specific method for detecting hepatic ischemia-reperfusion injury (HIRI) by creating neutrophil biomimetic microbubbles (MBneu). The MBneu retained neutrophil proteins, targeted inflamed hepatic tissue, and exhibited physicochemical properties typical of liposome-based microbubbles. The molecular ultrasound imaging of HIRI using MBneu may have promising applications in different clinical scenarios with various cell types in the future.