Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

Neoplastic cells are a rare component in human glioblastoma microvasculature

(2015) Fausto J. Rodriguez et al.   Oncotarget

Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy

(2012) An Verheyen et al.   BRAIN

Receptor Talk and Tumor Cell Walk in Glioblastoma

(2012) Lena Claesson-Welsh   CANCER CELL

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

SnapShot: Tumor Angiogenesis

(2012) Rakesh K. Jain et al.   CELL

Born to Die

(2012) Claudia Korn et al.   CIRCULATION

Plasma Biomarkers as Predictors of Outcome in Patients with Advanced Hepatocellular Carcinoma

(2012) J. M. Llovet et al.   CLINICAL CANCER RESEARCH

Is there a world beyond bevacizumab in targeting angiogenesis in glioblastoma?

(2012) Katharina Seystahl et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

TIE2-expressing monocytes: A novel cellular biomarker for hepatocellular carcinoma?

(2012) Michele De Palma et al.   HEPATOLOGY

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma

(2012) Adrian M Jubb et al.   HISTOPATHOLOGY

Glioblastoma-derived Tumor Cells Induce Vasculogenic Mimicry through Flk-1 Protein Activation

(2012) Ralph Francescone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

(2012) Marco Reis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

(2012) Petra Hamerlik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

(2012) Lothar C Dieterich et al.   JOURNAL OF PATHOLOGY

Cardiovascular and Systemic MicrovascularEffects of Anti-Vascular Endothelial Growth Factor Therapy for Cancer

(2012) J. Todd Belcik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

(2012) Tanja Holopainen et al.   JNCI-Journal of the National Cancer Institute

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

(2012) Annamaria Rapisarda et al.   Nature Reviews Clinical Oncology

Cilengitide Treatment for Malignant Glioma: Current Status and Future Direction

(2012) Kazuhiko KUROZUMI et al.   NEUROLOGIA MEDICO-CHIRURGICA

The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies

(2012) Ellen L. van Agtmaal et al.   PLoS One

Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors

(2012) Barbara Sennino et al.   Cancer Discovery

Ang2, the instigator of inflammation

(2011) H. Kim et al.   BLOOD

Angiopoietin-2 promotes myeloid cell infiltration in a  2-integrin-dependent manner

(2011) A. Scholz et al.   BLOOD

Multiple Effects of Angiopoietin-2 Blockade on Tumors

(2011) Claire E. Lewis et al.   CANCER CELL

Intussusceptive microvascular growth in tumors

(2011) Domenico Ribatti et al.   CANCER LETTERS

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

VEGF and c-Met Blockade Amplify Angiogenesis Inhibition in Pancreatic Islet Cancer

(2011) W.-K. You et al.   CANCER RESEARCH

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept

(2011) J. F. de Groot et al.   CLINICAL CANCER RESEARCH

Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth

(2011) H. Huang et al.   CLINICAL CANCER RESEARCH

Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development

(2011) Diane C. Darland et al.   DEVELOPMENTAL BIOLOGY

Targeting the Angiopoietin/Tie2 Pathway: Cutting Tumor Vessels With a Double-Edged Sword?

(2011) Tina Cascone et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical significance of vasculogenic mimicry in human gliomas

(2011) Xiao-mei Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Safety of concurrent bevacizumab therapy and anticoagulation in glioma patients

(2011) Andrew D. Norden et al.   JOURNAL OF NEURO-ONCOLOGY

A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma

(2011) Ashwatha Narayana et al.   JOURNAL OF NEUROSURGERY

Macrophages limit chemotherapy

(2011) Michele De Palma et al.   NATURE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

(2011) J. F. de Groot et al.   NEURO-ONCOLOGY

Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells

(2011) A. H. Sikkema et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

VEGFR2 Expression and TGF-β Signaling in Initial and Recurrent High-Grade Human Glioma

(2011) Elizabeth A. Kuczynski et al.   ONCOLOGY

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF in the nervous system

(2011) Jeffrey M. Rosenstein et al.   Organogenesis

Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy

(2010) V Goede et al.   BRITISH JOURNAL OF CANCER

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Recruitment of Myeloid but not Endothelial Precursor Cells Facilitates Tumor Regrowth after Local Irradiation

(2010) S. V. Kozin et al.   CANCER RESEARCH

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

(2010) S. B. Coffelt et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

(2010) S.-S. Chae et al.   CLINICAL CANCER RESEARCH

Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas

(2010) Ting He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma

(2010) Bi Cheng Zhang et al.   MEDICAL ONCOLOGY

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

(2010) J. L. Brown et al.   MOLECULAR CANCER THERAPEUTICS

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

The paradoxical effect of bevacizumab in the therapy of malignant gliomas

(2010) E. M. Thompson et al.   NEUROLOGY

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axon Guidance Molecules in Vascular Patterning

(2010) R. H. Adams et al.   Cold Spring Harbor Perspectives in Biology

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

"Antimyeloangiogenic" Therapy for Cancer by Inhibiting PlGF

(2009) S. Loges et al.   CLINICAL CANCER RESEARCH

Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time

(2009) Ivan Shabo et al.   INTERNATIONAL JOURNAL OF CANCER

Safety, Pharmacokinetics, and Antitumor Activity of AMG 386, a Selective Angiopoietin Inhibitor, in Adult Patients With Advanced Solid Tumors

(2009) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

(2009) Peter Carmeliet et al.   Nature Reviews Clinical Oncology

Antiangiogenic therapies for high-grade glioma

(2009) Andrew D. Norden et al.   Nature Reviews Neurology

Role and Therapeutic Potential of VEGF in the Nervous System

(2009) Carmen Ruiz de Almodovar et al.   PHYSIOLOGICAL REVIEWS

Flt-1 Signaling in Macrophages Promotes Glioma Growth In vivo

(2008) M. Kerber et al.   CANCER RESEARCH

VEGF Trap induces antiglioma effect at different stages of disease

(2008) Candelaria Gomez-Manzano et al.   NEURO-ONCOLOGY

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE