An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

Male mice are susceptible to high fat diet-induced hyperglycaemia and display increased circulatory retinol binding protein 4 (RBP4) levels and its expression in visceral adipose depots

(2016) Asha GV et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Diet-induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration

(2015) L. A. Brown et al.   Acta Physiologica

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice

(2015) Rockann E. Mosser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains

(2015) Yueqiang Xue et al.   BEHAVIOURAL BRAIN RESEARCH

Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy

(2015) Francisco Westermeier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

(2015) Eloise A Bradley et al.   Cardiovascular Diabetology

Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling

(2015) Nathan W. Roberts et al.   Cardiovascular Diabetology

Are reactive oxygen species still the basis for diabetic complications?

(2015) Elyse Di Marco et al.   CLINICAL SCIENCE

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer’s Disease

(2015) Domenico Nuzzo et al.   Current Alzheimer Research

Influence of high-fat diet on gut microbiota

(2015) E. Angela Murphy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium

(2015) Danielle A. Fontaine et al.   DIABETES

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes

(2015) Megan V. Cannon et al.   DIABETOLOGIA

Gut microorganisms as promising targets for the management of type 2 diabetes

(2015) Nathalie M. Delzenne et al.   DIABETOLOGIA

High-fat diet induces cardiomyocyte apoptosis via the inhibition of autophagy

(2015) Hsiu-Ching Hsu et al.   EUROPEAN JOURNAL OF NUTRITION

The Status of Research into Resistance to Diet-Induced Obesity

(2015) C. Ding et al.   HORMONE AND METABOLIC RESEARCH

High sugar and butter (HSB) diet induces obesity and metabolic syndrome with decrease in regulatory T cells in adipose tissue of mice

(2015) Tatiani Uceli Maioli et al.   INFLAMMATION RESEARCH

A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice

(2015) Salvatore Carbone et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A novel cobiotic-based preventive approach against high-fat diet-induced adiposity, nonalcoholic fatty liver and gut derangement in mice

(2015) D P Singh et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity induced by high fat diet attenuates postinfarct myocardial remodeling and dysfunction in adult B6D2F1 mice

(2015) Marcos Poncelas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sirt1 mediates the effects of a short-term high-fat diet on the heart

(2015) Joan Villarroya et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

(2015) Michal Ganz et al.   Journal of Translational Medicine

Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

(2015) Yan Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet

(2015) James P. Kesby et al.   PLoS One

Updating Experimental Models of Diabetic Cardiomyopathy

(2015) J. Fuentes-Antrás et al.   Journal of Diabetes Research

Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10

(2015) Varun Kesherwani et al.   Frontiers in Physiology

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

(2015) Lalage A. Katunga et al.   Molecular Metabolism

Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding

(2015) Nemanja Jovicic et al.   PLoS One

Revisiting the Thrifty Gene Hypothesis via 65 Loci Associated with Susceptibility to Type 2 Diabetes

(2014) Qasim Ayub et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice

(2014) Kristen A. Baltgalvis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Raman Imaging Providing Insights into Chemical Composition of Lipid Droplets of Different Size and Origin: In Hepatocytes and Endothelium

(2014) Katarzyna Majzner et al.   ANALYTICAL CHEMISTRY

Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice

(2014) Jian Cai et al.   Cardiovascular Diabetology

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

(2014) Brandyn D. Henriksbo et al.   DIABETES

Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance

(2014) Tomoyuki Watanabe et al.   EXPERIMENTAL CELL RESEARCH

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

(2014) Zhiguo Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes

(2014) Hui-Young Lee et al.   MAMMALIAN GENOME

The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia

(2014) Aaron J. Mull et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Searching for Genomic Region of High-Fat Diet-Induced Type 2 Diabetes in Mouse Chromosome 2 by Analysis of Congenic Strains

(2014) Misato Kobayashi et al.   PLoS One

Can Evidence from Genome-Wide Association Studies and Positive Natural Selection Surveys Be Used to Evaluate the Thrifty Gene Hypothesis in East Asians?

(2014) Xuan-Han Koh et al.   PLoS One

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

(2013) Emily K. Sims et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice

(2013) K. Tajima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin resistance protects the heart from fuel overload in dysregulated metabolic states

(2013) Heinrich Taegtmeyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains

(2013) Ayca Dogan et al.   BMC GENOMICS

Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats

(2013) Nattayaporn Apaijai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2013) Giridhar Kanuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lessons from Mouse Models of High-Fat Diet-Induced NAFLD

(2013) Akinobu Nakamura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

(2013) Shaodong Guo   JOURNAL OF ENDOCRINOLOGY

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy

(2013) Sebastián D. Calligaris et al.   PLoS One

High Fat Feeding in Mice Is Insufficient to Induce Cardiac Dysfunction and Does Not Exacerbate Heart Failure

(2013) Robert E. Brainard et al.   PLoS One

The effects of obesity on skeletal muscle regeneration

(2013) Dmitry Akhmedov et al.   Frontiers in Physiology

Assessment of brown adipose tissue function

(2013) Sam Virtue et al.   Frontiers in Physiology

Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis

(2013) Melanie Kahle et al.   Molecular Metabolism

Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets

(2012) Giulio R. Romeo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Is reactivation of autophagy a possible therapeutic solution for obesity and metabolic syndrome?

(2012) Sebastiano Sciarretta et al.   Autophagy

Dietary Fat and Heart Failure: Moving From Lipotoxicity to Lipoprotection

(2012) William C. Stanley et al.   CIRCULATION RESEARCH

A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis

(2012) J. R. Speakman et al.   Disease Models & Mechanisms

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetic Cardiomyopathy

(2012) Joel D. Schilling et al.   Heart Failure Clinics

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity

(2011) Qun Wang et al.   ATHEROSCLEROSIS

High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects

(2011) T. F. Galvao et al.   CARDIOVASCULAR RESEARCH

Voluntary Exercise Improves High-Fat Diet-Induced Leptin Resistance Independent of Adiposity

(2011) Kimberly A. Krawczewski Carhuatanta et al.   ENDOCRINOLOGY

Wound Healing in Mice with High-Fat Diet- orobGene-Induced Diabetes-Obesity Syndromes: A Comparative Study

(2011) Oliver Seitz et al.   Experimental Diabetes Research

Immunity as a link between obesity and insulin resistance

(2011) Nishan S. Kalupahana et al.   MOLECULAR ASPECTS OF MEDICINE

Impaired Muscle Regeneration in Ob/ob and Db/db Mice

(2011) Mai-Huong Nguyen et al.   TheScientificWorldJOURNAL

PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet

(2010) Z. Hu et al.   DIABETES

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content

(2010) Niloofar Hariri et al.   NUTRITION RESEARCH

Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism

(2009) Y. Macotela et al.   DIABETES

Experimental rodent models of type 2 diabetes: A review

(2009) M.S. Islam et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription

(2008) Cindy X. Fang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

(2008) E. D. Berglund et al.   DIABETES

The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective

(2008) Mariana Lazo et al.   SEMINARS IN LIVER DISEASE