Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

(2015) A. R. R. Maia et al.   ANNALS OF ONCOLOGY

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Dissecting the roles of human BUB1 in the spindle assembly checkpoint

(2015) M. Vleugel et al.   JOURNAL OF CELL SCIENCE

Discovery of Imidazo[1,2-b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity

(2015) Ken-ichi Kusakabe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

(2015) Ricardo Martinez et al.   PLoS One

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

(2015) Shyam Nyati et al.   Science Signaling

Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling

(2015) Carlos Sacristan et al.   TRENDS IN CELL BIOLOGY

Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation

(2015) Adeel Asghar et al.   Nature Communications

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

(2015) Conrad von Schubert et al.   Cell Reports

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

(2015) Shyam Nyati et al.   Science Signaling

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

(2014) J. Bancroft et al.   JOURNAL OF CELL SCIENCE

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

(2014) Zhonghui Lin et al.   STRUCTURE

Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo

(2014) F. H. Gohard et al.   Open Biology

Characterization of novel MPS1 inhibitors with preclinical anticancer activity

(2013) M Jemaà et al.   CELL DEATH AND DIFFERENTIATION

Mitosis as an anti-cancer drug target

(2013) Anna-Leena Salmela et al.   CHROMOSOMA

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation

(2013) Hironori Funabiki et al.   CHROMOSOMA

Phospho-H2A and Cohesin Specify Distinct Tension-Regulated Sgo1 Pools at Kinetochores and Inner Centromeres

(2013) Hong Liu et al.   CURRENT BIOLOGY

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation

(2013) Mathijs Vleugel et al.   JOURNAL OF CELL BIOLOGY

Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs

(2013) Bakhos A. Tannous et al.   JNCI-Journal of the National Cancer Institute

Tension sensing by Aurora B kinase is independent of survivin-based centromere localization

(2013) Christopher S. Campbell et al.   NATURE

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

(2013) Philippe Collin et al.   NATURE CELL BIOLOGY

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Mps1 promotes rapid centromere accumulation of Aurora B

(2012) Maike S van der Waal et al.   EMBO REPORTS

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

(2012) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Structural analysis reveals features of the spindle checkpoint kinase Bub1–kinetochore subunit Knl1 interaction

(2012) Veronica Krenn et al.   JOURNAL OF CELL BIOLOGY

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

(2012) Anna De Antoni et al.   JOURNAL OF CELL BIOLOGY

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cohesion Fatigue Explains Why Pharmacological Inhibition of the APC/C Induces a Spindle Checkpoint-Dependent Mitotic Arrest

(2012) Pablo Lara-Gonzalez et al.   PLoS One

Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin

(2012) Jiamu Du et al.   STRUCTURE

Sister Chromatid Cohesion

(2012) J.-M. Peters et al.   Cold Spring Harbor Perspectives in Biology

The Aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe

(2011) Yungan Tao et al.   CELL CYCLE

A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis

(2011) Fangwei Wang et al.   CURRENT BIOLOGY

The kinetochore protein Bub1 participates in the DNA damage response

(2011) Chunying Yang et al.   DNA REPAIR

Probing thein vivofunction of Mad1:C-Mad2 in the spindle assembly checkpoint

(2011) Luca L Fava et al.   EMBO JOURNAL

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Bub1 and BubR1: at the Interface between Chromosome Attachment and the Spindle Checkpoint

(2011) S. Elowe   MOLECULAR AND CELLULAR BIOLOGY

Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1

(2011) K. D. Tardif et al.   MOLECULAR CANCER THERAPEUTICS

Spindle assembly checkpoint: the third decade

(2011) A. Musacchio   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

(2010) R. Colombo et al.   CANCER RESEARCH

Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres

(2010) Y. Tanno et al.   GENES & DEVELOPMENT

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Release of Mps1 from kinetochores is crucial for timely anaphase onset

(2010) Nannette Jelluma et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis

(2010) D. Perera et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation

(2010) Tatsuya Tsukahara et al.   NATURE

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

BUB1 and BUBR1: multifaceted kinases of the cell cycle

(2010) Victor M. Bolanos-Garcia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

(2009) Barry E. McGuinness et al.   CURRENT BIOLOGY

Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments

(2009) Zhenye Yang et al.   JOURNAL OF CELL BIOLOGY

Bub1 regulates chromosome segregation in a kinetochore-independent manner

(2009) Christiane Klebig et al.   JOURNAL OF CELL BIOLOGY

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

(2008) Zuojun Yue et al.   JOURNAL OF CELL BIOLOGY

The Human Spindle Assembly Checkpoint Protein Bub3 Is Required for the Establishment of Efficient Kinetochore–Microtubule Attachments

(2008) Elsa Logarinho et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

(2008) Jungseog Kang et al.   MOLECULAR CELL

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

(2008) Brian G. Fuller et al.   NATURE

The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells

(2008) Daniela A. Brito et al.   CELL MOTILITY AND THE CYTOSKELETON