Characterization of novel MPS1 inhibitors with preclinical anticancer activity

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Preferential killing of p53-deficient cancer cells by reversine

(2012) Mohamed Jemaà et al.   CELL CYCLE

Transgenerational cell fate profiling

(2012) Mohamed Jemaà et al.   CELL CYCLE

Killing cells by targeting mitosis

(2012) E Manchado et al.   CELL DEATH AND DIFFERENTIATION

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

Selective killing of p53-deficient cancer cells by SP600125

(2012) Mohamed Jemaà et al.   EMBO Molecular Medicine

Cell division control by the Chromosomal Passenger Complex

(2012) Maike S. van der Waal et al.   EXPERIMENTAL CELL RESEARCH

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning

(2011) Christopher P. Mattison et al.   CELL CYCLE

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest

(2011) Hongqing Liang et al.   EMBO JOURNAL

Cytokinesis, ploidy and aneuploidy

(2011) Benjamin Lacroix et al.   JOURNAL OF PATHOLOGY

Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1

(2011) K. D. Tardif et al.   MOLECULAR CANCER THERAPEUTICS

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological Relevance of Cell Cycle Kinases

(2011) Marcos Malumbres   PHYSIOLOGICAL REVIEWS

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells

(2011) J. Daniel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

Centriole assembly and the role of Mps1: defensible or dispensable?

(2011) Amanda N Pike et al.   Cell Division

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

(2010) R. Colombo et al.   CANCER RESEARCH

Illicit survival of cancer cells during polyploidization and depolyploidization

(2010) I Vitale et al.   CELL DEATH AND DIFFERENTIATION

Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

(2010) Ilio Vitale et al.   EMBO JOURNAL

A chemical tool box defines mitotic and interphase roles for Mps1 kinase

(2010) Weijie Lan et al.   JOURNAL OF CELL BIOLOGY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

(2010) Tale Sliedrecht et al.   PLoS One

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Sister chromatid tension and the spindle assembly checkpoint

(2009) Luigi Nezi et al.   CURRENT OPINION IN CELL BIOLOGY

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

(2009) Y.-F. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1

(2009) Y-H Yeh et al.   ONCOGENE

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

(2008) Maria Teresa Landi et al.   PLoS One

Defining ‘chromosomal instability’

(2008) Jochen B. Geigl et al.   TRENDS IN GENETICS