Article
Chemistry, Applied
Laura Gallego-Yerga, Cristina de la Torre, Francesco Sansone, Alessandro Casnati, Carmen Ortiz Mellet, Jose M. Garcia Fernandez, Valentin Cena
Summary: Cyclodextrin-calixarene giant amphiphiles are capable of encapsulating and delivering anticancer drugs to tumor cells with high efficiency, significantly enhancing therapeutic efficacy. The redox-responsive disulfide bridge modification in these amphiphiles allows for efficient cargo release in a tumor microenvironment, leading to potent inhibition of cancer cell proliferation.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Zhongjie Fei, Mehdi Yoosefian
Summary: This study investigates the assembly mechanism of Ribociclib encapsulated by DPC micelle using all-atom molecular dynamics simulations. The main forces involved in the drug encapsulation process are hydrophobic and van der Waals interactions, with hydrogen bonding and electrostatic interactions also contributing. Solvent accessible surface area and radial distribution function analyses show that DPC micelles can improve the aqueous solubility of hydrophobic drugs, providing a new pathway for designing drug delivery systems with necessary properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Medicinal
Lutete Peguy Khonde, Rudolf Mueller, Grant A. Boyle, Virsinha Reddy, Aloysius T. Nchinda, Charles J. Eyermann, Stephen Fienberg, Vinayak Singh, Alissa Myrick, Efrem Abay, Mathew Njoroge, Nina Lawrence, Qin Su, Timothy G. Myers, Helena I. M. Boshoff, Clifton E. Barry, Frederick A. Sirgel, Paul D. van Helden, Lisa M. Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gregory S. Basarab, Sandeep R. Ghorpade, Kelly Chibale
Summary: A study identified a moderately active compound against Mycobacterium tuberculosis through high-throughput screening, with potential bactericidal activity and retention of activity against drug-resistant strains. Initial investigations suggested inhibition of cell wall biosynthesis as a possible mode of action, but the specific mechanism remains unclear.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Shixian Lv, Meilyn Sylvestre, Kefan Song, Suzie H. Pun
Summary: Melittin, the primary peptide component in bee venom, has anti-tumor activity but its practical application is hindered by hemolytic activity and instability. Use of D-amino acids in place of L-amino acids reduces immunogenicity of melittin, allowing for safer delivery and maintaining cytolytic potential. D-melittin micelles show cytotoxicity in a pH-dependent manner, inducing immunogenic cell death and demonstrating potential for cancer immunotherapy. The study presents a new strategy for systemic delivery of cytotoxic peptides in cancer treatment.
Review
Cell Biology
Ting Wu, Xinsheng Gu, Hongmei Cui
Summary: Chemotherapy resistance poses a significant challenge in cancer treatment, and Skp2, as an E3 ligase, is closely associated with drug resistance and poor prognosis. This review summarizes the mechanisms through which Skp2 confers drug resistance, including its involvement in cell cycle regulation, DNA damage repair, and other pathways. New molecules targeting Skp2 interactions may hold promise for improving outcomes in cancer patients.
Review
Biochemistry & Molecular Biology
Eloise Ducrey, Cedric Castrogiovanni, Patrick Meraldi, Patrycja Nowak-Sliwinska
Summary: Mitosis, controlled by microtubules, is an attractive target for anti-cancer treatments due to frequent and uncontrolled cell divisions in cancer cells. However, current treatments have severe disadvantages and often lead to resistance mechanisms. Combinatorial treatments targeting spindle pole clustering have emerged as a potential alternative, specifically targeting cancer cells with aberrant centrosome numbers.
Review
Pharmacology & Pharmacy
Raef Shams, Yoshihiro Ito, Hideyuki Miyatake
Summary: mTOR is a protein kinase involved in cell growth and proliferation, which can be assembled into mTORC1 and mTORC2 complexes with different functions. In cancer cells, mTOR is hyperactivated to adapt to stress conditions, leading to efforts in developing compounds to inhibit mTOR and disrupt cancer cell metabolism.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Ziqi Zhao, Jungan Zhang, Yixin Ren, Luyao Dong, Han Wu, Wei Hong, Huoqiang Huang, Xinyi Yang, Zongran Pang, Hao Wang
Summary: A new sub-binding pocket was discovered by molecular modeling, and a series of compounds were designed and synthesized as potential PRMT1 inhibitors. Two compounds (ZJG51 and ZJG58) showed significant inhibitory activities against PRMT1 without inhibiting PRMT5, and displayed potent inhibitory effects on the proliferation of cancer-derived cell lines. ZJG51 specifically inhibited migration and induced apoptosis of cervical cancer cells, possibly by activating Caspase 9 and inhibiting EMT.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Na Qu, Zongguang Hui, Zhixin Shen, Chengxia Kan, Ningning Hou, Xiaodong Sun, Fang Han
Summary: This review examines the influence of COVID-19 on the pathogenesis, diagnosis, and treatment of thyroid cancer, with a focus on drug therapies for thyroid cancer patients with COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Zohaib Rana, Sarah Diermeier, Fearghal P. Walsh, Muhammad Hanif, Christian G. Hartinger, Rhonda J. Rosengren
Summary: The novel HDAC inhibitors Jazz90 and Jazz167 showed higher cancer-cell selectivity and anti-angiogenic effects in metastatic castration-resistant prostate cancer cells compared to SAHA, with no toxicity observed in mice, indicating potential for further in vivo studies.
Review
Biochemistry & Molecular Biology
Vishal Singh, Tayyaba Afshan, Pankaj Tyagi, Pritish Kumar Varadwaj, Amaresh Kumar Sahoo
Summary: Multi-target therapies are a viable option to overcome drug-resistant cancer cells. With the use of a single drug against multiple structurally similar sites, it modulates several vital cellular pathways and reduces the usage of multiple drugs. However, drug resistance against anti-cancer agents targeting topoisomerase II has been observed, leading to the proposal of multi-target therapies to overcome different resistance mechanisms. This review discusses the binding cavity characteristics for drug interactions, potent inhibitors, and drug resistance mechanisms in various types of cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Hyein Jo, Kyeonghee Shim, Dooil Jeoung
Summary: Histone deacetylases (HDACs) are protein deacetylases that regulate gene expression by modifying chromatin structure. Among them, HDAC6 is localized in the cytoplasm and is involved in the deacetylation of non-histone proteins. It plays diverse roles in cancer cell initiation, proliferation, autophagy, and anti-cancer drug resistance. The development of HDAC6-specific inhibitors has shown promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Cindy Schelker, Patrycja Nowak-Sliwinska, Gerrit Borchard
Summary: Fixed-drug combinations have been used for cancer treatment, but current therapies have limitations in terms of resistance and toxicity. The combination of tyrosine kinase inhibitors and histone deacetylase inhibitors is being investigated in clinical trials and has shown promising results. Utilizing appropriate drug delivery systems, such as nanocarriers, can further enhance the activity and specificity of drug combinations. Strategies for the delivery of synergistic drug combinations for cancer treatment are discussed in this review.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Nanoscience & Nanotechnology
Piper A. Rawding, Jiyoon Bu, Jianxin Wang, Da Won Kim, Adam J. Drelich, Youngsoo Kim, Seungpyo Hong
Summary: Cancer immunotherapy utilizes the patient's immune system to treat cancer, but currently, it is only effective in a small subset of patients. Nanoparticles have been used as carriers for immunotherapeutic drugs, showing robust anti-tumor effects.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Abid Ali Ahmad, Kashif Hussain, Muhammad Raza Shah, Syed Muhammad Ashhad Halimi, Fazle Rabbi, Zahoor Ahmad, Inamullah Khan, Abdur Rauf, Abdulrahman Alshammari, Metab Alharbi, Hafiz Ansar Rasul Suleria
Summary: The aim of this study was to discover and explore highly potent and efficacious cyclooxygenase inhibitors using indole acetic acid drugs as a starting point. Derivatives of indomethacin, the selected lead compound, were synthesized and their structure and analogues were determined through spectroscopic procedures. The synthesized analogues were then screened for acute toxicity, anti-nociceptive and anti-inflammatory activity, and protein-ligand interaction. The results showed that the derivatives exhibited significant analgesic and anti-inflammatory activities, suggesting their potential as new drug candidates for pain and inflammation.
Article
Oncology
Jenni Heidi Eveliina Maki-Jouppila, Sofia Pruikkonen, Mahesh Balasaheb Tambe, Miriam Ragle Aure, Tuuli Halonen, Anna-Leena Salmela, Leena Laine, Anne-Lise Borresen-Dale, Marko Johannes Kallio
MOLECULAR ONCOLOGY
(2015)
Article
Oncology
E. Narvi, K. Jaakkola, S. Winsel, C. Oetken-Lindholm, P. Halonen, L. Kallio, M. J. Kallio
BRITISH JOURNAL OF CANCER
(2013)
Article
Oncology
Iina Niittymaki, Alexandra Gylfe, Leena Laine, Marko Laakso, Heli J. Lehtonen, Johanna Kondelin, Jaana Tolvanen, Kari Nousiainen, Jeroen Pouwels, Heikki Jarvinen, Kyosti Nuorva, Jukka-Pekka Mecklin, Markus Makinen, Ari Ristimaki, Torben F. Orntoft, Sampsa Hautaniemi, Auli Karhu, Marko J. Kallio, Lauri A. Aaltonen
Article
Oncology
Anna-Leena Salmela, Jeroen Pouwels, Jenni Maki-Jouppila, Pekka Kohonen, Pauliina Toivonen, Lila Kallio, Marko Kallio
Editorial Material
Cardiac & Cardiovascular Systems
Juhani Knuuti, Antti Saraste, Marko Kallio, Heikki Minn
EUROPEAN HEART JOURNAL
(2013)
Article
Oncology
Anna-Leena Salmela, Jeroen Pouwels, Anu Kukkonen-Macchi, Sinikka Waris, Pauliina Toivonen, Kimmo Jaakkola, Jenni Maki-Jouppila, Lila Kallio, Marko J. Kallio
EXPERIMENTAL CELL RESEARCH
(2012)
Article
Cell Biology
Alexandra N. Elsing, Camilla Aspelin, Johanna K. Bjork, Heidi A. Bergman, Samu V. Himanen, Marko J. Kallio, Pia Roos-Mattjus, Lea Sistonen
JOURNAL OF CELL BIOLOGY
(2014)
Article
Cell Biology
Anu Kukkonen-Macchi, Oana Sicora, Katarzyna Kaczynska, Christina Oetken-Lindholm, Jeroen Pouwels, Leena Laine, Marko J. Kallio
JOURNAL OF CELL SCIENCE
(2011)
Article
Biochemistry & Molecular Biology
Johanna K. Ahlskog, Johanna K. Bjork, Alexandra N. Elsing, Camilla Aspelin, Marko Kallio, Pia Roos-Mattjus, Lea Sistonen
MOLECULAR AND CELLULAR BIOLOGY
(2010)
Article
Cell Biology
E. M. Nilsson, L. J. S. Brokken, E. Narvi, M. J. Kallio, P. L. Harkonen
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2012)
Article
Oncology
Jenni H. E. Maki-Jouppila, Leena J. Laine, Jonathan Rehnberg, Elli Narvi, Pekka Tiikkainen, Elvira Hukasova, Pasi Halonen, Arne Lindqvist, Lila Kallio, Antti Poso, Marko J. Kallio
MOLECULAR CANCER THERAPEUTICS
(2014)
Article
Oncology
Tim H. Holmstrom, Jonathan Rehnberg, Leena J. Ahonen, Marko J. Kallio
MOLECULAR ONCOLOGY
(2009)
Article
Oncology
Mariaana Vuoriluoto, Leena J. Laine, Petri Saviranta, Jeroen Pouwels, Marko J. Kallio
MOLECULAR ONCOLOGY
(2011)
Article
Multidisciplinary Sciences
Kemal Alpay, Mehdi Farshchian, Johanna Tuomela, Jouko Sandholm, Kaappo Aittokallio, Elina Siljamaki, Marko Kallio, Veli-Matti Kahari, Sakari Hietanen
