Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Zika Virus

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A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

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Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

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Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

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The dengue virus NS5 protein as a target for drug discovery

(2015) Siew Pheng Lim et al.   ANTIVIRAL RESEARCH

Discovery of Dengue Virus NS4B Inhibitors

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Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

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A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

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Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

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The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

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Ten years of dengue drug discovery: Progress and prospects

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Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization

(2013) Holger Hannemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

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Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

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The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state

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Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

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Structural biology of dengue virus enzymes: Towards rational design of therapeutics

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Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial

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2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

(2012) Hongping Dong et al.   PLoS Pathogens

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

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Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

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Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

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2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

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N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase

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NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

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An adenosine nucleoside inhibitor of dengue virus

(2009) Z. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

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The flavivirus polymerase as a target for drug discovery

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Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus

(2008) Michela Bollati et al.   JOURNAL OF MOLECULAR BIOLOGY

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

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Modification of intracellular membrane structures for virus replication

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