期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 24, 页码 7934-7937出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm901044z
关键词
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A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and it preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.
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