Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

(2015) Christine Schuberth-Wagner et al.   IMMUNITY

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

(2015) Yongqian Zhao et al.   JOURNAL OF VIROLOGY

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Flavivirus RNA methylation

(2014) H. Dong et al.   JOURNAL OF GENERAL VIROLOGY

Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial

(2014) Maria Rosario Capeding et al.   LANCET

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

(2014) Jenny G Low et al.   LANCET INFECTIOUS DISEASES

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation

(2014) Miroslaw Smietanski et al.   Nature Communications

Ten years of dengue drug discovery: Progress and prospects

(2013) Siew Pheng Lim et al.   ANTIVIRAL RESEARCH

Membrane Topology and Function of Dengue Virus NS2A Protein

(2013) X. Xie et al.   JOURNAL OF VIROLOGY

Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5' Capped 2'-O Unmethylated RNA

(2013) T. Kimura et al.   JOURNAL OF VIROLOGY

Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2'-O Methylation

(2013) S.-H. Li et al.   JOURNAL OF VIROLOGY

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

(2012) Hongping Dong et al.   PLoS Pathogens

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

(2012) Barbara Selisko et al.   PLoS Pathogens

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

Conventional and unconventional mechanisms for capping viral mRNA

(2011) Etienne Decroly et al.   NATURE REVIEWS MICROBIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

(2010) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

(2010) Li Jian Yap et al.   PLoS One

Biochemical and genetic characterization of dengue virus methyltransferase

(2010) Hongping Dong et al.   VIROLOGY

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

(2010) Ka Yan Chung et al.   VIROLOGY

A scintillation proximity assay for dengue virus NS5 2′-O-methyltransferase—kinetic and inhibition analyses

(2008) S LIM et al.   ANTIVIRAL RESEARCH

Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus

(2008) Michela Bollati et al.   JOURNAL OF MOLECULAR BIOLOGY

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

(2008) H. Dong et al.   JOURNAL OF VIROLOGY