The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Comparison of dengue virus and HCV: from impact on global health to their RNA-dependent RNA polymerases

(2014) Supanee Potisopon et al.   Future Virology

Flavivirus RNA methylation

(2014) H. Dong et al.   JOURNAL OF GENERAL VIROLOGY

Functional interplay among the flavivirus NS3 protease, helicase, and cofactors

(2014) Kuohan Li et al.   VIROLOGICA SINICA

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

(2013) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein

(2013) C. S. E. Tan et al.   JOURNAL OF GENERAL VIROLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state

(2013) Parag Surana et al.   NUCLEIC ACIDS RESEARCH

Surprising New Dengue Virus Throws a Spanner in Disease Control Efforts

(2013) D. Normile   SCIENCE

Protein–protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells

(2013) Li Yu et al.   VIROLOGY

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Establishment of a robust dengue virus NS3–NS5 binding assay for identification of protein–protein interaction inhibitors

(2012) Hirotaka Takahashi et al.   ANTIVIRAL RESEARCH

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

(2012) N. Scrima et al.   JOURNAL OF VIROLOGY

Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus

(2012) A. A. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture and regulation of negative-strand viral enzymatic machinery

(2012) Philip J. Kranzusch et al.   RNA Biology

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

(2012) Hongping Dong et al.   PLoS Pathogens

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

(2012) Barbara Selisko et al.   PLoS Pathogens

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen

(2011) Marc Le Breton et al.   BMC MICROBIOLOGY

Nucleoproteins and nucleocapsids of negative-strand RNA viruses

(2011) Rob WH Ruigrok et al.   CURRENT OPINION IN MICROBIOLOGY

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2′-ethynyl-7-deaza-adenosine triphosphate

(2010) Derek R. Latour et al.   ANTIVIRAL RESEARCH

Cytoplasmic Viral Replication Complexes

(2010) Johan A. den Boon et al.   Cell Host & Microbe

RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase

(2010) Claudia V. Filomatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

Classical swine fever virus NS3 enhances RNA-dependent RNA polymerase activity by binding to NS5B

(2009) Ping Wang et al.   VIRUS RESEARCH

Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA

(2008) B. Zhang et al.   JOURNAL OF VIROLOGY