标题
A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases
作者
关键词
Protein domains, Trypanosoma cruzi, Network analysis, Drug discovery, Plasmodium, Proteomes, Drug discovery for neglected diseases, Neglected tropical diseases
出版物
PLoS Neglected Tropical Diseases
Volume 10, Issue 1, Pages e0004300
出版商
Public Library of Science (PLoS)
发表日期
2016-01-07
DOI
10.1371/journal.pntd.0004300
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Network-based gene prediction for Plasmodium falciparum malaria towards genetics-based drug discovery
- (2015) Yang Chen et al. BMC GENOMICS
- The promise and peril of chemical probes
- (2015) Cheryl H Arrowsmith et al. Nature Chemical Biology
- Neglected Tropical Diseases in the Post-Genomic Era
- (2015) Carlos A. Buscaglia et al. TRENDS IN GENETICS
- New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource
- (2015) Imanol Peña et al. Scientific Reports
- Large-Scale Chemical Similarity Networks for Target Profiling of Compounds Identified in Cell-Based Chemical Screens
- (2015) Yu-Chen Lo et al. PLoS Computational Biology
- Ligand-Target Prediction by Structural Network Biology Using nAnnoLyze
- (2015) Francisco Martínez-Jiménez et al. PLoS Computational Biology
- The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution
- (2015) Krystyna Cwiklinski et al. GENOME BIOLOGY
- Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
- (2015) Marcel Kaiser et al. PLoS One
- InterProScan 5: genome-scale protein function classification
- (2014) P. Jones et al. BIOINFORMATICS
- Probabilistic drug connectivity mapping
- (2014) Juuso A Parkkinen et al. BMC BIOINFORMATICS
- Isoprenoid Biosynthesis in Plasmodium falciparum
- (2014) Ann M. Guggisberg et al. EUKARYOTIC CELL
- Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)
- (2014) Mark D. Rackham et al. JOURNAL OF MEDICINAL CHEMISTRY
- Polypharmacology: Challenges and Opportunities in Drug Discovery
- (2014) Andrew Anighoro et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drug Development and FDA Approval, 1938–2013
- (2014) Jonathan J. Darrow et al. NEW ENGLAND JOURNAL OF MEDICINE
- DINIES: drug–target interaction network inference engine based on supervised analysis
- (2014) Yoshihiro Yamanishi et al. NUCLEIC ACIDS RESEARCH
- Genetic Profiling of the Isoprenoid and Sterol Biosynthesis Pathway Genes of Trypanosoma cruzi
- (2014) Raúl O. Cosentino et al. PLoS One
- Drug–target interaction prediction through domain-tuned network-based inference
- (2013) Salvatore Alaimo et al. BIOINFORMATICS
- Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides
- (2013) Stephen P. Muench et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, Synthesis, Structural Characterization by IR,1H,13C,15N, 2D-NMR, X-Ray Diffraction and Evaluation of a New Class of Phenylaminoacetic Acid Benzylidene Hydrazines aspfENR Inhibitors
- (2013) Ramanuj P. Samal et al. Chemical Biology & Drug Design
- Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents
- (2013) Florian C. Schrader et al. ChemMedChem
- Network-Based Approaches in Drug Discovery and Early Development
- (2013) J M Harrold et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines
- (2013) Guangxu Jin et al. DRUG DISCOVERY TODAY
- Computational Profiling of Bioactive Compounds Using a Target-Dependent Composite Workflow
- (2013) Jamel Meslamani et al. Journal of Chemical Information and Modeling
- Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors of Plasmodium falciparum Enoyl-ACP-reductase (PfFabI)
- (2013) Federica Belluti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Structure–Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum
- (2013) Komagal Kannan Sivaraman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inositol 1,4,5-trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protistTrypanosoma cruzi
- (2013) Muneaki Hashimoto et al. MOLECULAR MICROBIOLOGY
- Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential forPlasmodium yoeliiliver-stage development
- (2013) Scott E. Lindner et al. MOLECULAR MICROBIOLOGY
- Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
- (2013) M. Iskar et al. Molecular Systems Biology
- The genomes of four tapeworm species reveal adaptations to parasitism
- (2013) Isheng J. Tsai et al. NATURE
- Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
- (2013) Megan H. Wright et al. Nature Chemistry
- Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
- (2013) Christopher A Desjardins et al. NATURE GENETICS
- DrugBank 4.0: shedding new light on drug metabolism
- (2013) Vivian Law et al. NUCLEIC ACIDS RESEARCH
- N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis
- (2013) EDWARD W. TATE et al. PARASITOLOGY
- The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases
- (2013) Thomas Spangenberg et al. PLoS One
- Predicting Drug-Target Interactions for New Drug Compounds Using a Weighted Nearest Neighbor Profile
- (2013) Twan van Laarhoven et al. PLoS One
- Drug Target Prediction and Repositioning Using an Integrated Network-Based Approach
- (2013) Dorothea Emig et al. PLoS One
- Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity
- (2013) G. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Challenges and opportunities of drug repositioning
- (2013) Natalia Novac TRENDS IN PHARMACOLOGICAL SCIENCES
- Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
- (2012) Sophie Marhadour et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis
- (2012) Valter Viana Andrade-Neto et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum
- (2012) Marcin Poreba et al. PLoS One
- Global Analysis of Small Molecule Binding to Related Protein Targets
- (2012) Felix A. Kruger et al. PLoS Computational Biology
- Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference
- (2012) Feixiong Cheng et al. PLoS Computational Biology
- Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm
- (2011) Muneaki Hashimoto et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The role of indirect connections in gene networks in predicting function
- (2011) Jesse Gillis et al. BIOINFORMATICS
- Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase
- (2011) Akhtar Muhammad et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Old friends in new guise: repositioning of known drugs with structural bioinformatics
- (2011) V. J. Haupt et al. BRIEFINGS IN BIOINFORMATICS
- Target Validation: Linking Target and Chemical Properties to Desired Product Profile
- (2011) Paul G. Wyatt et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Drug discovery for neglected tropical diseases at the Sandler Center
- (2011) Stephanie A Robertson et al. Future Medicinal Chemistry
- Target repurposing for neglected diseases
- (2011) Michael P Pollastri et al. Future Medicinal Chemistry
- Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer
- (2011) Daniel P. Sutherlin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Analysis of multiple compound-protein interactions reveals novel bioactive molecules
- (2011) H. Yabuuchi et al. Molecular Systems Biology
- TDR Targets: a chemogenomics resource for neglected diseases
- (2011) M. P. Magarinos et al. NUCLEIC ACIDS RESEARCH
- KEGG for integration and interpretation of large-scale molecular data sets
- (2011) M. Kanehisa et al. NUCLEIC ACIDS RESEARCH
- ChEMBL: a large-scale bioactivity database for drug discovery
- (2011) A. Gaulton et al. NUCLEIC ACIDS RESEARCH
- Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
- (2011) M. B. Harbut et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework
- (2010) Y. Yamanishi et al. BIOINFORMATICS
- When is Chemical Similarity Significant? The Statistical Distribution of Chemical Similarity Scores and Its Extreme Values
- (2010) Pierre Baldi et al. Journal of Chemical Information and Modeling
- Protein kinase A catalytic subunit interacts and phosphorylates members of trans-sialidase super-family in Trypanosoma cruzi
- (2010) Yi Bao et al. MICROBES AND INFECTION
- Functionality Pattern Matching as an Efficient Complementary Structure/Reaction Search Tool: an Open-Source Approach
- (2010) Norbert Haider MOLECULES
- Thousands of chemical starting points for antimalarial lead identification
- (2010) Francisco-Javier Gamo et al. NATURE
- Chemical genetics of Plasmodium falciparum
- (2010) W. Armand Guiguemde et al. NATURE
- Rethinking screening
- (2010) Thomas Kodadek Nature Chemical Biology
- Discovery of drug mode of action and drug repositioning from transcriptional responses
- (2010) F. Iorio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach
- (2010) Gregory J. Crowther et al. PLoS Neglected Tropical Diseases
- The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum – New tools for designing specific inhibitors
- (2009) Diana Bahia et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections
- (2009) Galina I. Lepesheva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Predicting new molecular targets for known drugs
- (2009) Michael J. Keiser et al. NATURE
- Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
- (2009) Tina S. Skinner-Adams et al. TRENDS IN BIOCHEMICAL SCIENCES
- Draft Genome Sequencing of Giardia intestinalis Assemblage B Isolate GS: Is Human Giardiasis Caused by Two Different Species?
- (2009) Oscar Franzén et al. PLoS Pathogens
- Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors
- (2008) Christopher W. am Ende et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Role of Protein Kinase A in Trypanosoma cruzi
- (2008) Y. Bao et al. INFECTION AND IMMUNITY
- ATrypanosoma cruziPhosphatidylinositol 3-Kinase (TcVps34) Is Involved in Osmoregulation and Receptor-mediated Endocytosis
- (2008) Alejandra C. Schoijet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors
- (2008) P. Ross-Macdonald et al. MOLECULAR CANCER THERAPEUTICS
- Genomic-scale prioritization of drug targets: the TDR Targets database
- (2008) Fernán Agüero et al. NATURE REVIEWS DRUG DISCOVERY
- Drug Target Identification Using Side-Effect Similarity
- (2008) M. Campillos et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started