Network-Based Approaches in Drug Discovery and Early Development

Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

(2013) P Vicini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

Drug Target Prediction and Repositioning Using an Integrated Network-Based Approach

(2013) Dorothea Emig et al.   PLoS One

Observability of complex systems

(2013) Y.-Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Modeling of ERBB2-Amplified Breast Cancer Identifies Combined ErbB2/3 Blockade as Superior to the Combination of MEK and AKT Inhibitors

(2013) D. C. Kirouac et al.   Science Signaling

Network-based drug discovery by integrating systems biology and computational technologies

(2012) E. L. Leung et al.   BRIEFINGS IN BIOINFORMATICS

Combinatorial Chemotherapeutic Efficacy in Non-Hodgkin Lymphoma Can Be Predicted by a Signaling Model of CD20 Pharmacodynamics

(2012) J. M. Harrold et al.   CANCER RESEARCH

Temporal networks

(2012) Petter Holme et al.   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

Merging Systems Biology with Pharmacodynamics

(2012) R. Iyengar et al.   Science Translational Medicine

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology

(2011) Aarash Bordbar et al.   BMC Systems Biology

Generalized walks-based centrality measures for complex biological networks

(2010) Ernesto Estrada   JOURNAL OF THEORETICAL BIOLOGY

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

An optimization model for metabolic pathways

(2009) F. J. Planes et al.   BIOINFORMATICS

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder

(2009) Holly A. Garriock et al.   BIOLOGICAL PSYCHIATRY

Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

(2009) Özgür Sahin et al.   BMC Systems Biology

Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology

(2009) P. D. Karp et al.   BRIEFINGS IN BIOINFORMATICS

Cancer systems biology: a network modeling perspective

(2009) P. K. Kreeger et al.   CARCINOGENESIS

Attacking Cancer at Its Root

(2009) Craig B. Thompson   CELL

The role of incretins in cardiovascular control

(2009) Derek D. Mafong et al.   CURRENT HYPERTENSION REPORTS

A unifying view of 21st century systems biology

(2009) Marc Vidal   FEBS LETTERS

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

(2009) Philip D Home et al.   LANCET

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Therapeutic targets to reduce cardiovascular disease in type 2 diabetes

(2009) Cyrus DeSouza et al.   NATURE REVIEWS DRUG DISCOVERY

The University of Minnesota Biocatalysis/Biodegradation Database: improving public access

(2009) Junfeng Gao et al.   NUCLEIC ACIDS RESEARCH

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases

(2009) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Biochemical mechanisms in drug-induced liver injury: Certainties and doubts

(2009) Ignazio Grattagliano et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Information Flow Analysis of Interactome Networks

(2009) Patrycja Vasilyev Missiuro et al.   PLoS Computational Biology

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Gene regulatory network inference: Data integration in dynamic models—A review

(2008) Michael Hecker et al.   BIOSYSTEMS

Osteopontin Promotes Vascular Endothelial Growth Factor Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms

(2008) G. Chakraborty et al.   CANCER RESEARCH

Identification of Information Flow-Modulating Drug Targets: A Novel Bridging Paradigm for Drug Discovery

(2008) W-C Hwang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Network medicine

(2008) Tony Pawson et al.   FEBS LETTERS

Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis I: Mechanistic Disease Progression Model for the Time Course of Collagen-Induced Arthritis in Lewis Rats

(2008) J. C. Earp et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Revealing unique properties of the ribosome using a network based analysis

(2008) Hilda David-Eden et al.   NUCLEIC ACIDS RESEARCH

BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009

(2008) A. Chang et al.   NUCLEIC ACIDS RESEARCH

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes

(2008) K. K. Danielson et al.   OSTEOPOROSIS INTERNATIONAL

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE