期刊
BIOINFORMATICS
卷 27, 期 13, 页码 1860-1866出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr288
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资金
- National Institutes of Health [GM076990]
- Michael Smith Foundation for Health Research
- Canadian Institutes for Health Research
- CIHR
- MSFHR
- MIND Foundation of British Columbia
Motivation: Gene networks have been used widely in gene function prediction algorithms, many based on complex extensions of the 'guilt by association' principle. We sought to provide a unified explanation for the performance of gene function prediction algorithms in exploiting network structure and thereby simplify future analysis. Results: We use co-expression networks to show that most exploited network structure simply reconstructs the original correlation matrices from which the co-expression network was obtained. We show the same principle works in predicting gene function in protein interaction networks and that these methods perform comparably to much more sophisticated gene function prediction algorithms.
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