Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

Quantifying Ubiquitin Signaling

(2015) Alban Ordureau et al.   MOLECULAR CELL

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

(2015) Sonal Nagarkar-Jaiswal et al.   eLife

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

(2014) Shinya Yamamoto et al.   CELL

Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila

(2014) Q Huang et al.   CELL DEATH AND DIFFERENTIATION

Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis

(2014) B. Blanco-Sanchez et al.   Disease Models & Mechanisms

Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer

(2014) Sheng Yang et al.   GENE

Large-scale identification of chemically induced mutations inDrosophila melanogaster

(2014) Nele A. Haelterman et al.   GENOME RESEARCH

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

(2014) Paul A. DaRosa et al.   NATURE

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling

(2014) Y. C. Liu et al.   Science Signaling

Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11

(2014) Wu-Lin Charng et al.   PLOS BIOLOGY

New insights into the regulation of Axin function in canonical Wnt signaling pathway

(2014) Xiaomin Song et al.   Protein & Cell

Knockdown of Cyclin-dependent Kinase 10 (cdk10) Gene Impairs Neural Progenitor Survival via Modulation ofraf1aGene Expression

(2013) Chi-Wei Yeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

(2013) Li-En Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

(2013) Ashish Kumar Maurya et al.   PLoS Genetics

Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish

(2013) X. Wang et al.   Biology Open

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

Distinct Phosphorylations on Kinesin Costal-2 Mediate Differential Hedgehog Signaling Strength

(2012) Nadia Ranieri et al.   DEVELOPMENTAL CELL

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands

(2012) S. Yamamoto et al.   SCIENCE

Crag Is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells

(2012) Bo Xiong et al.   PLOS BIOLOGY

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome

(2012) R Kimberley Cook et al.   GENOME BIOLOGY

Hedgehog Signaling Regulates Nociceptive Sensitization

(2011) Daniel T. Babcock et al.   CURRENT BIOLOGY

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

(2011) Claudia Dafinger et al.   JOURNAL OF CLINICAL INVESTIGATION

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes

(2011) Audrey Putoux et al.   NATURE GENETICS

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

(2011) Cornelia Meisenberg et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Genetic and biochemical definition of the Hedgehog receptor

(2010) X. Zheng et al.   GENES & DEVELOPMENT

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

(2010) J. D. Sander et al.   NUCLEIC ACIDS RESEARCH

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling

(2009) Pia Aanstad et al.   CURRENT BIOLOGY

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling

(2009) C. L. Hammond et al.   DEVELOPMENT

Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila

(2009) Hillary K Andrews et al.   EMBO REPORTS

A Drosophila Resource of Transgenic RNAi Lines for Neurogenetics

(2009) Jian-Quan Ni et al.   GENETICS

Disruption of Mitochondrial DNA Replication in Drosophila Increases Mitochondrial Fast Axonal Transport In Vivo

(2009) Rehan M. Baqri et al.   PLoS One

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Accumulation of Rhodopsin in Late Endosomes Triggers Photoreceptor Cell Degeneration

(2009) Yashodhan Chinchore et al.   PLoS Genetics

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway

(2008) Marco J Koudijs et al.   BMC DEVELOPMENTAL BIOLOGY

Costal2 Functions as a Kinesin-like Protein in the Hedgehog Signal Transduction Pathway

(2008) Shohreh F. Farzan et al.   CURRENT BIOLOGY

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

The role of kinases in the Hedgehog signalling pathway

(2008) Reid A Aikin et al.   EMBO REPORTS

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

The Substrate Recognition Domains of the N-end Rule Pathway

(2008) Takafumi Tasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY