Article
Cell Biology
Thomas J. Krzystek, Joseph A. White, Rasika Rathnayake, Layne Thurston, Hayley Hoffmar-Glennon, Yichen Li, Shermali Gunawardena
Summary: This study reveals a novel role for HTT in the retrograde movement of a Rab7-LAMP1-containing signaling late endosome and identifies adaptors Hip1 and Rilpl as important factors in this process.
Article
Biology
Mengjing Bao, Ruth E. Doerig, Paula Maria Vazquez-Pianzola, Dirk Beuchle, Beat Suter
Summary: In this study, the glutamylation of a-tubulin isotypes in Drosophila ovaries was investigated. It was found that the C-terminal ends of alpha Tub84B/D were glutamylated, while alpha Tub67C was not. TTLL5 was identified as the protein responsible for mono- and poly-glutamylation of alpha Tub84B/D and its proper localization. This study also demonstrated the dependence of kinesin-1 distribution, as well as other cellular functions such as axonal transport and ooplasmic streaming, on TTLL5 and alpha-tubulin glutamylation.
Article
Biochemistry & Molecular Biology
Gustavo Carvalho, Bruno Marcal Repoles, Isabela Mendes, Paulina H. Wanrooij
Summary: Research has focused on maintenance and instability of mitochondrial DNA, exploring the role of DNA repair factors in mitochondria and the connection between mtDNA damage and immune response. Future studies should delve into mechanisms by which mitochondria maintain mtDNA, the balance between repair and degradation, as well as the release of mtDNA into the cytosol.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell Biology
Thomas J. Krzystek, Rupkatha Banerjee, Layne Thurston, JianQiao Huang, Kelsey Swinter, Saad Navid Rahman, Tomas L. Falzone, Shermali Gunawardena
Summary: Mitochondria are dynamic organelles crucial for cellular homeostasis, regulated by fission-fusion cycles and motility of healthy/damaged mitochondria. Disruption of this regulation can lead to oxidative stress and neurodegenerative diseases.Alpha-synuclein plays a role in mitochondrial homeostasis, influencing fragmentation, oxidation, and motility, and may interact with PINK/Parkin in the pathogenesis of Parkinson's disease.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Chun-Yi Cho, James P. Kemp, Robert J. Duronio, Patrick H. O'Farrell
Summary: Collisions between DNA replication forks and transcribing RNA polymerases disrupt gene transcription, especially during the rapid cell cycles of early embryonic development. Replication dependency defers the onset of transcription to maintain orderly progression and avoid conflicts between transcription and replication.
Article
Neurosciences
Amrita Mandal, Hiu-Tung C. Wong, Katherine Pinter, Natalie Mosqueda, Alisha Beirl, Richa Madan Lomash, Sehoon Won, Katie S. Kindt, Catherine M. Drerup
Summary: Research shows that retrograde mitochondrial transport plays a crucial role in maintaining the homeostatic distribution of mitochondria in neurons, and disrupting this process can lead to accumulation of aged organelles in axon terminals and loss of mitochondria in the cell body.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maithili Saoji, Aditya Sen, Rachel T. Cox
Summary: The study revealed the subtle functions of mtRNase P in vivo, showing that the loss of a specific member can lead to different cleavage effects, which may improve the understanding of human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Baptiste Grimaud, Maxence Fretaud, Feriel Terras, Antoine Benassy, Karine Duroure, Valerie Bercier, Gaelle Trippe-Allard, Rabei Mohammedi, Thierry Gacoin, Filippo Del Bene, Francois Marquier, Christelle Langevin, Francois Treussart
Summary: This study measured fast axonal transport by tracing the SHG signal of nanoKTP endocytosed by zebrafish larvae brain neurons. The researchers confirmed the feasibility of the method by using different mutants and inhibitors, and accurately monitored subtle alterations in axonal transport in the brain.
Editorial Material
Cell Biology
Angelika B. Harbauer, Thomas L. Schwarz
Summary: In this study, the authors found that axonal mitophagy relies on local translation of Pink1 mRNA. The co-transport of Pink1 mRNA with mitochondria in neurons plays a crucial role in mitophagy in the distal parts of the cell. This finding contributes to our understanding of mitochondrial homeostasis in neurons.
Review
Microbiology
Simona Amodeo, Irina Bregy, Torsten Ochsenreiter
Summary: This article summarizes the diversity of mitochondrial DNA replication and proposes a new replication model using Trypanosoma brucei as an example, providing a mechanism for the maintenance of mitochondrial genetic diversity.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Cell Biology
Cara R. Schiavon, Gerald S. Shadel, Uri Manor
Summary: CMT disease is a progressive, inherited neurological disorder associated with mutations in at least 80 different genes. Clinical manifestations typically involve peripheral neurons, with some mutations potentially leading to mitochondrial mobility defects, suggesting a common underlying disease mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Rachel A. Hoffman, Heather K. MacAlpine, David M. MacAlpine
Summary: This study provides insights into helicase activation within origin chromatin and its regulation in the absence of DNA replication. Activation of the helicase disrupts and disorganizes chromatin, extending up to 1 kb from early replication origins. The local sequence context plays a role in regulating helicase progression when uncoupled from replication.
GENES & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Monika Olahova, Bradley Peter, Zsolt Szilagyi, Hector Diaz-Maldonado, Meenakshi Singh, Ewen W. Sommerville, Emma L. Blakely, Jack J. Collier, Emily Hoberg, Viktor Stranecky, Hana Hartmannova, Anthony J. Bleyer, Kim L. McBride, Sasigarn A. Bowden, Zuzana Korandova, Alena Pecinova, Hans-Hilger Ropers, Kimia Kahrizi, Hossein Najmabadi, Mark A. Tarnopolsky, Lauren I. Brady, K. Nicole Weaver, Carlos E. Prada, Katrin Ounap, Monica H. Wojcik, Sander Pajusalu, Safoora B. Syeda, Lynn Pais, Elicia A. Estrella, Christine C. Bruels, Louis M. Kunkel, Peter B. Kang, Penelope E. Bonnen, Tomas Mracek, Stanislav Kmoch, Grainne S. Gorman, Maria Falkenberg, Claes M. Gustafsson, Robert W. Taylor
Summary: Variants in the POLRMT gene lead to defective mitochondrial transcription, causing mitochondrial disease-related phenotypes. Researchers have demonstrated this important disease mechanism through in vivo and in vitro experiments.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Takeshi Yoshimura, Yohei Iguchi, Masahisa Katsuno, Ryosuke Takahashi, Hiroshi Kiyama
Summary: The study reveals that proteasome-sensitive disassembly of the axon initial segment (AIS) may be a critical response for damaged motor neurons to temporarily transition to an immature state and meet energy demands.
Article
Multidisciplinary Sciences
Adam R. Fenton, Thomas A. Jongens, Erika L. F. Holzbaur
Summary: Mitochondria are transported along microtubules by opposing kinesin and dynein motors, linked by TRAK adaptor proteins. TRAK2 activates kinesin-1 for transport toward the plus-end of microtubules and acts as a dynein activating adaptor for transport toward the minus-end. At a sufficient level, the dynein-binding protein LIS1 is necessary for efficient dynein-mediated TRAK2 transport. TRAK2 forms a complex containing both kinesin-1 and dynein-dynactin, functionally linking these motors and coordinating their activities for proper mitochondrial transport.
NATURE COMMUNICATIONS
(2021)
Article
Biophysics
Matthew O'Toole, Phillip Lamoureux, Kyle E. Miller
BIOPHYSICAL JOURNAL
(2015)
Review
Neurosciences
Douglas H. Roossien, Kyle E. Miller, Gianluca Gallo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Kyle E. Miller, Xin-An Liu, Sathyanarayanan V. Puthanveettil
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Mathematics, Interdisciplinary Applications
R. de Rooij, K. E. Miller, E. Kuhl
COMPUTATIONAL MECHANICS
(2017)
Editorial Material
Neurosciences
Kyle E. Miller, Daniel M. Suter
FRONTIERS IN CELLULAR NEUROSCIENCE
(2016)
Article
Cell Biology
Douglas H. Roossien, Phillip Lamoureux, Kyle E. Miller
JOURNAL OF CELL SCIENCE
(2014)
Article
Cell Biology
Rehan M. Baqri, Arielle V. Pietron, Rewatee H. Gokhale, Brittany A. Turner, Laurie S. Kaguni, Alexander W. Shingleton, Sam Kunes, Kyle E. Miller
MECHANISMS OF AGEING AND DEVELOPMENT
(2014)
Article
Multidisciplinary Sciences
Douglas H. Roossien, Phillip Lamoureux, David Van Vactor, Kyle E. Miller
Article
Multidisciplinary Sciences
Ahmad I. M. Athamneh, Yingpei He, Phillip Lamoureux, Lucas Fix, Daniel M. Suter, Kyle E. Miller
SCIENTIFIC REPORTS
(2017)
Article
Biophysics
Rijk de Rooij, Ellen Kuhl, Kyle E. Miller
BIOPHYSICAL JOURNAL
(2018)
Review
Neurosciences
Kyle E. Miller, Daniel M. Suter
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Cell Biology
Kerriann K. Badal, Komol Akhmedov, Phillip Lamoureux, Xin-An Liu, Adrian Reich, Mohammad Fallahi-Sichani, Supriya Swarnkar, Kyle E. Miller, Sathyanarayanan V. Puthanveettil
Article
Cell Biology
Kristi McElmurry, Jessica E. Stone, Donghan Ma, Phillip Lamoureux, Yueyun Zhang, Michelle Steidemann, Lucas Fix, Fang Huang, Kyle E. Miller, Daniel M. Suter
JOURNAL OF CELL SCIENCE
(2020)
Article
Neurosciences
Katherine Halievski, Michael Q. Kemp, S. Marc Breedlove, Kyle E. Miller, Cynthia L. Jordan
Article
Engineering, Biomedical
Maria A. Holland, Kyle E. Miller, Ellen Kuhl
ANNALS OF BIOMEDICAL ENGINEERING
(2015)