Article
Multidisciplinary Sciences
Ana R. Moshkovsky, Marc W. Kirschner
Summary: Axin is a crucial protein in the canonical Wnt pathway, and its differential regulation allows for tissue-specific functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Samuel Trujano-Camacho, David Cantu-de Leon, Izamary Delgado-Waldo, Jossimar Coronel-Hernandez, Oliver Millan-Catalan, Daniel Hernandez-Sotelo, Cesar Lopez-Camarillo, Carlos Perez-Plasencia, Alma D. Campos-Parra
Summary: In cervical cancer patients, many genes of the Wnt/beta-catenin pathway are dysregulated, indicating the pathway's aberrant activation. In vitro experiments showed that the drug C59 efficiently inhibits the Wnt/beta-catenin pathway in CC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rui Zhang, Shuai Yu, Qiaoyan Shen, Wenxu Zhao, Juqing Zhang, Xiaolong Wu, Zhenshuo Zhu, Xiaojie Wu, Na Li, Sha Peng, Jinlian Hua
Summary: The study discovered that overexpression of the porcine AXIN2 gene significantly decreased the survival and pluripotency of piPSCs, while knockdown of AXIN2, a negative effector of the WNT signaling pathway, enhanced genes related to cell cycle but reduced genes associated with cell differentiation, death, and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qingqing Wu, Xiaoyang Luo, Mikkel G. Terp, Qingrun Li, Yuan Li, Lei Shen, Ying Chen, Kirstine Jacobsen, Trever G. Bivona, Haiquan Chen, Rong Zeng, Henrik J. Ditzel
Summary: Early recurrence is a major obstacle in prolonged postoperative survival for squamous cell lung carcinoma (SqCLC). DDX56 was identified as an independent prognostic biomarker in SqCLC patients, promoting early recurrence through post-transcriptional regulation of Wnt signaling genes via miRNA-mediated effects. These findings suggest DDX56 may help identify SqCLC patients at risk for early recurrence and could benefit from Wnt signaling-targeted therapies.
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Polymer Science
Yongyao Lei, Yougen Chen
Summary: Eight novel alternating copolymers were successfully synthesized through the post-polymerization modification of poly(propylene-alt-allyl alcohol)100 (PPAA100), which cannot be accessed using general methodologies. The chemical transformations of the hydroxyl group in PPAA100 resulted in the formation of eight unique head-to-head alternating copolymers with fixed propylene structural units and allyl alcohol derived monomeric units. The obtained polymers were characterized using 1H and 13C NMR and FT-IR spectroscopies, and their thermal properties were investigated.
Article
Biochemistry & Molecular Biology
Mingyi Li, Jing Zheng, Dong Luo, Kai Xu, Ren Sheng, Bryan T. MacDonald, Xi He, Xinjun Zhang
Summary: The membrane-tethered protease Tiki inhibits Wnt signaling by cleaving and inactivating Wnt3a. It requires Frizzled (FZD) receptors to antagonize Wnt signaling at the cell surface. Tiki cleaves the N-terminus of Wnt3a or Wnt5a in the Wnt-FZD complex, preventing the recruitment and activation of coreceptors.
Article
Chemistry, Multidisciplinary
Yuehang Pan, Makoto Ouchi
Summary: Isotactic polyacrylate and polyacrylamide were synthesized through stereospecific radical polymerization of a pendant-transformable monomer, acrylamide, followed by post-polymerization modification (PPM). The study revealed that the pendant of the polymer was more reactive than that of the monomer, making it suitable for aminolysis reaction. Addition of lithium triflate and triethylamine was effective in promoting the alcoholysis reaction. Poly(methyl acrylate) (PMA) with higher isotacticity was obtained via the radical polymerization of acrylamide in the presence of lithium triflate and subsequent addition of methanol and triethylamine.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Joachim F. R. Van Guyse, Yann Bernhard, Annelore Podevyn, Richard Hoogenboom
Summary: Non-activated esters have prominent features in polymer science but their low reactivity prevents their direct use in post-polymerization modification. However, utilizing non-activated esters for modification is still a valuable opportunity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Bruckner, Vladimir L. Katanaev, Jurgen Behrens, Dominic B. Bernkopf
Summary: This study finds that G alpha i2 can induce the condensation of conductin, leading to the degradation of β-catenin and inhibition of Wnt signaling, thus suppressing the growth of colorectal cancer. Colorectal cancer evades this inhibition by decreasing the expression of G alpha i2 and inactivating mutations, but the G alpha i2-activating drug guanabenz can reduce colorectal cancer growth.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
William Agbemafle, Min May Wong, Diane C. Bassham
Summary: This review summarizes key regulatory mechanisms for modulating autophagy through post-translational modification or transcriptional regulation. Plants activate cellular responses to adapt to changing environmental conditions, one of which is autophagy, where cellular components are delivered to the vacuole for degradation. Autophagy is activated by various conditions, and the pathways controlling its activation are being elucidated. However, there is still much to discover regarding how these factors work together to properly modulate autophagy in response to specific signals.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Behavioral Sciences
Milka Martinez, C. Nibaldo Inestrosa
Summary: Alzheimer's disease is a neurological disorder that primarily affects the elderly, characterized by progressive cognitive decline and loss of autonomy. Transcriptional changes in susceptible signaling pathways, particularly the Wnt signaling pathway, have been linked to synaptic dysfunction and neuronal degeneration, highlighting synapse failure as a key pathological event in early stages of the disease.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Cell Biology
Brittany J. Bisnett, Brett M. Condon, Caitlin H. Lamb, George R. Georgiou, Michael Boyce
Summary: COPII, an ancient and essential pathway in eukaryotes, mediates forward trafficking of protein and lipid cargoes from the endoplasmic reticulum. Despite its broad significance, major aspects of COPII trafficking remain incompletely understood. Recent studies have highlighted the role of post-transcriptional mechanisms in regulating the COPII pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
