Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
出版年份 2016 全文链接
标题
Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
作者
关键词
Sequence alignment, G protein coupled receptors, Crystal structure, Protein structure comparison, Multiple alignment calculation, Sequence motif analysis, Phylogenetic analysis, Protein structure prediction
出版物
PLoS Computational Biology
Volume 12, Issue 3, Pages e1004805
出版商
Public Library of Science (PLoS)
发表日期
2016-03-31
DOI
10.1371/journal.pcbi.1004805
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism
- (2015) James AR Dalton et al. BMC BIOINFORMATICS
- GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors
- (2015) Santiago Rios et al. BMC BIOINFORMATICS
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014
- (2015) Alexander Heifetz et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation
- (2015) Daniel G. Isom et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generic GPCR residue numbers – aligning topology maps while minding the gaps
- (2015) Vignir Isberg et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Sequence, Structure and Ligand Binding Evolution of Rhodopsin-Like G Protein-Coupled Receptors: A Crystal Structure-Based Phylogenetic Analysis
- (2015) Steffen Wolf et al. PLoS One
- The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin
- (2014) Aashish Manglik et al. CURRENT OPINION IN CELL BIOLOGY
- Structured and disordered facets of the GPCR fold
- (2014) AJ Venkatakrishnan et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
- (2014) Andrew S. Doré et al. NATURE
- Structure of the human P2Y12 receptor in complex with an antithrombotic drug
- (2014) Kaihua Zhang et al. NATURE
- Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptor
- (2014) R. Abrol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
- (2014) H. Wu et al. SCIENCE
- Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
- (2014) Irina Kufareva et al. STRUCTURE
- Structure of class B GPCR corticotropin-releasing factor receptor 1
- (2013) Kaspar Hollenstein et al. NATURE
- Structure of the human smoothened receptor bound to an antitumour agent
- (2013) Chong Wang et al. NATURE
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Structure of the human glucagon class B G-protein-coupled receptor
- (2013) Fai Yiu Siu et al. NATURE
- Molecular signatures of G-protein-coupled receptors
- (2013) A. J. Venkatakrishnan et al. NATURE
- GPCRDB: an information system for G protein-coupled receptors
- (2013) Vignir Isberg et al. NUCLEIC ACIDS RESEARCH
- Towards Improved Quality of GPCR Models by Usage of Multiple Templates and Profile-Profile Comparison
- (2013) Dorota Latek et al. PLoS One
- SuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations
- (2013) J. K. Bray et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
- (2013) D. Wootten et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding
- (2013) Kwang H. Ahn et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Critical assessment of methods of protein structure prediction (CASP) - round x
- (2013) John Moult et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex
- (2013) Q. Tan et al. SCIENCE
- Structural Basis for Molecular Recognition at Serotonin Receptors
- (2013) C. Wang et al. SCIENCE
- Serial Femtosecond Crystallography of G Protein-Coupled Receptors
- (2013) W. Liu et al. SCIENCE
- Using ortholog sequence data to predict the functional relevance of mutations in G-protein-coupled receptors
- (2012) Maxi Cöster et al. FASEB JOURNAL
- Structure of the δ-opioid receptor bound to naltrindole
- (2012) Sébastien Granier et al. NATURE
- Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
- (2012) Kazuko Haga et al. NATURE
- Structure of the human κ-opioid receptor in complex with JDTic
- (2012) Huixian Wu et al. NATURE
- Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
- (2012) Aaron A. Thompson et al. NATURE
- Structure of the agonist-bound neurotensin receptor
- (2012) Jim F. White et al. NATURE
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
- (2012) Aashish Manglik et al. NATURE
- Structure and dynamics of the M3 muscarinic acetylcholine receptor
- (2012) Andrew C. Kruse et al. NATURE
- High-resolution crystal structure of human protease-activated receptor 1
- (2012) Cheng Zhang et al. NATURE
- The GPCR Network: a large-scale collaboration to determine human GPCR structure and function
- (2012) Raymond C. Stevens et al. NATURE REVIEWS DRUG DISCOVERY
- IUPHAR-DB: updated database content and new features
- (2012) J. L. Sharman et al. NUCLEIC ACIDS RESEARCH
- The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi
- (2012) Arunkumar Krishnan et al. PLoS One
- Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations
- (2012) Caitlin E. Scott et al. PROTEIN SCIENCE
- Crystal Structure of a Lipid G Protein-Coupled Receptor
- (2012) M. A. Hanson et al. SCIENCE
- GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models
- (2011) Catherine L Worth et al. BMC BIOINFORMATICS
- Structural Basis of Activation of Bitter Taste Receptor T2R1 and Comparison with Class A G-protein-coupled Receptors (GPCRs)
- (2011) Nisha Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins
- (2011) Ravinder Abrol et al. METHODS
- Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
- (2011) Ka Young Chung et al. NATURE
- Structure of the human histamine H1 receptor complex with doxepin
- (2011) Tatsuro Shimamura et al. NATURE
- Crystal structure of metarhodopsin II
- (2011) Hui-Woog Choe et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment
- (2011) Michael Remmert et al. NATURE METHODS
- Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy
- (2011) I. Letunic et al. NUCLEIC ACIDS RESEARCH
- Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptor
- (2011) Soo-Kyung Kim et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Structure of an Agonist-Bound Human A2A Adenosine Receptor
- (2011) F. Xu et al. SCIENCE
- Status of GPCR Modeling and Docking as Reflected by Community-wide GPCR Dock 2010 Assessment
- (2011) Irina Kufareva et al. STRUCTURE
- The role of conformational ensembles of seven transmembrane receptors in functional selectivity
- (2010) Nagarajan Vaidehi et al. CURRENT OPINION IN PHARMACOLOGY
- MetaPhOrs: orthology and paralogy predictions from multiple phylogenetic evidence using a consistency-based confidence score
- (2010) Leszek P. Pryszcz et al. NUCLEIC ACIDS RESEARCH
- A series of PDB related databases for everyday needs
- (2010) R. P. Joosten et al. NUCLEIC ACIDS RESEARCH
- Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
- (2010) T. Kenakin et al. PHARMACOLOGICAL REVIEWS
- Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
- (2010) B. Wu et al. SCIENCE
- Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
- (2010) E. Y. T. Chien et al. SCIENCE
- Jalview Version 2--a multiple sequence alignment editor and analysis workbench
- (2009) A. M. Waterhouse et al. BIOINFORMATICS
- The structure and function of G-protein-coupled receptors
- (2009) Daniel M. Rosenbaum et al. NATURE
- Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008
- (2009) Mayako Michino et al. NATURE REVIEWS DRUG DISCOVERY
- Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models
- (2009) Catherine L. Worth et al. PLoS One
- Prediction of membrane protein structures with complex topologies using limited constraints
- (2009) P. Barth et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of New GPCR Biology: One Receptor Structure at a Time
- (2009) Michael A. Hanson et al. STRUCTURE
- Structure of a β1-adrenergic G-protein-coupled receptor
- (2008) Tony Warne et al. NATURE
- The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
- (2008) V.-P. Jaakola et al. SCIENCE
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