Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System

Pharmacological reactivation of p53 as a strategy to treat cancer

(2015) J. Zawacka-Pankau et al.   JOURNAL OF INTERNAL MEDICINE

Computational Analysis of an Autophagy/Translation Switch Based on Mutual Inhibition of MTORC1 and ULK1

(2015) Paulina Szymańska et al.   PLoS One

The Pharmacodynamics of the p53-Mdm2 Targeting Drug Nutlin: The Role of Gene-Switching Noise

(2014) Krzysztof Puszynski et al.   PLoS Computational Biology

Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate

(2013) Marta N Bogdał et al.   BMC Systems Biology

Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis

(2013) Jakub Pękalski et al.   PLoS One

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate

(2013) Daniel Schultz et al.   Scientific Reports

Multistability with a Metastable Mixed State

(2012) Kim Sneppen et al.   PHYSICAL REVIEW LETTERS

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

(2011) A. Yoshimi et al.   BLOOD

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma

(2011) Shangwen Liu et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Expression of a Homeostatic Regulator, Wip1 (Wild-type p53-induced Phosphatase), Is Temporally Induced by c-Jun and p53 in Response to UV Irradiation

(2010) Ji-young Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination between Cell Cycle Progression and Cell Fate Decision by the p53 and E2F1 Pathways in Response to DNA Damage

(2010) Xiao-Peng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

(2010) Marie-Josée Langlois et al.   PLoS One

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Exploring mechanisms of oscillations in p53 and nuclear factor-κB systems

(2009) B. Hat et al.   IET Systems Biology

Nuclear Factor-κB (NF-κB) Is a Novel Positive Transcriptional Regulator of the Oncogenic Wip1 Phosphatase

(2009) Julie M. Lowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIPK2 modulates p53 activity towards pro-apoptotic transcription

(2009) Rosa Puca et al.   Molecular Cancer

The Estrogen Receptor   Pathway Induces Oncogenic Wip1 Phosphatase Gene Expression

(2009) H.-S. Han et al.   MOLECULAR CANCER RESEARCH

Oscillations of the p53-Akt Network: Implications on Cell Survival and Death

(2009) Keng Boon Wee et al.   PLoS One

Cell fate decision mediated by p53 pulses

(2009) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer

(2008) A. Astanehe et al.   JOURNAL OF CELL SCIENCE

Oscillations and bistability in the stochastic model of p53 regulation

(2008) Krzysztof Puszyński et al.   JOURNAL OF THEORETICAL BIOLOGY

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

(2008) Matteo Rossi et al.   NUCLEIC ACIDS RESEARCH