标题
Pharmacological reactivation of p53 as a strategy to treat cancer
作者
关键词
-
出版物
JOURNAL OF INTERNAL MEDICINE
Volume 277, Issue 2, Pages 248-259
出版商
Wiley
发表日期
2014-12-11
DOI
10.1111/joim.12336
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents
- (2014) M N Saha et al. BRITISH JOURNAL OF CANCER
- Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
- (2014) Patricia A.J. Muller et al. CANCER CELL
- A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity
- (2014) Karita Peltonen et al. CANCER CELL
- Drugging the p53 pathway: understanding the route to clinical efficacy
- (2014) Kian Hoe Khoo et al. NATURE REVIEWS DRUG DISCOVERY
- Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation
- (2014) N. Rivlin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Targeting of Wild-Type and Mutant p53 by Small Molecule RITA Results in the Inhibition of N-Myc and Key Survival Oncogenes and Kills Neuroblastoma Cells In Vivo and In Vitro
- (2013) M. Burmakin et al. CLINICAL CANCER RESEARCH
- Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development
- (2013) Qingjie Ding et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice
- (2013) Yujun Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma By Induction of p73 and Noxa
- (2013) Manujendra N. Saha et al. MOLECULAR CANCER THERAPEUTICS
- Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity
- (2013) Antonio Garcia Trinidad et al. MOLECULAR CELL
- Mutational heterogeneity in cancer and the search for new cancer-associated genes
- (2013) Michael S. Lawrence et al. NATURE
- Small molecule induced reactivation of mutant p53 in cancer cells
- (2013) Xiangrui Liu et al. NUCLEIC ACIDS RESEARCH
- Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
- (2013) Yong S. Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
- (2013) Binh Vu et al. ACS Medicinal Chemistry Letters
- Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53
- (2013) Christopher D. Wassman et al. Nature Communications
- Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers
- (2013) Henry Garcia et al. Cell Reports
- Allele-Specific p53 Mutant Reactivation
- (2012) Xin Yu et al. CANCER CELL
- Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
- (2012) Megan J. Bywater et al. CANCER CELL
- Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy
- (2012) Q. Li et al. CLINICAL CANCER RESEARCH
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- (2012) Qi Zhang et al. EMBO Molecular Medicine
- The substitutions G245C and G245D in the Zn2+-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain
- (2012) S.S. Pintus et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer
- (2012) Sören Lehmann et al. JOURNAL OF CLINICAL ONCOLOGY
- Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
- (2012) Isabelle Ray-Coquard et al. LANCET ONCOLOGY
- MDM4 is a key therapeutic target in cutaneous melanoma
- (2012) Agnieszka Gembarska et al. NATURE MEDICINE
- The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
- (2012) Bernard Leroy et al. NUCLEIC ACIDS RESEARCH
- Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
- (2012) B. Graves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2
- (2012) S. M. Vogel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p73 tumor suppressor protein: A close relative of p53 not only in structure but also in anti-cancer approach?
- (2011) Joanna Zawacka-Pankau et al. CELL CYCLE
- PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo
- (2011) Wenjie Bao et al. CELL CYCLE
- Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX
- (2011) C Spinnler et al. CELL DEATH AND DIFFERENTIATION
- SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
- (2011) D Li et al. CELL DEATH AND DIFFERENTIATION
- PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53
- (2011) R. Zandi et al. CLINICAL CANCER RESEARCH
- Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
- (2011) D. Li et al. MOLECULAR CANCER RESEARCH
- The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation
- (2011) A Y Ali et al. ONCOGENE
- Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3
- (2011) M H Aziz et al. ONCOGENE
- Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
- (2011) M Michaelis et al. Cell Death & Disease
- Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay
- (2011) A. G. Herman et al. Cancer Discovery
- Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73
- (2010) Chao Lu et al. CANCER BIOLOGY & THERAPY
- Rescue of p53 Function by Small-Molecule RITA in Cervical Carcinoma by Blocking E6-Mediated Degradation
- (2010) C. Y. Zhao et al. CANCER RESEARCH
- Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy
- (2010) Meng Ling Choong et al. CELL CYCLE
- Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA
- (2010) Carolyn Y. Zhao et al. CELL CYCLE
- Identification and Characterization of the First Small Molecule Inhibitor of MDMX
- (2010) Damon Reed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53
- (2010) Mark Demma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein−Protein Interactions
- (2010) Ji Hoon Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The missing Zinc: p53 misfolding and cancer
- (2010) Stewart N. Loh Metallomics
- A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis
- (2010) H. Wang et al. MOLECULAR CANCER THERAPEUTICS
- Selective activation of p53-mediated tumour suppression in high-grade tumours
- (2010) Melissa R. Junttila et al. NATURE
- Stage-specific sensitivity to p53 restoration during lung cancer progression
- (2010) David M. Feldser et al. NATURE
- Drug discovery and mutant p53
- (2010) Magda M. Maslon et al. TRENDS IN CELL BIOLOGY
- MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
- (2009) Martin Enge et al. CANCER CELL
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
- (2009) Jeremy M.R. Lambert et al. CANCER CELL
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- A comparison between p53 accumulation determined by immunohistochemistry andTP53mutations as prognostic variables in tumours from breast cancer patients
- (2008) Jan Alsner et al. ACTA ONCOLOGICA
- Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator
- (2008) Sonia Lain et al. CANCER CELL
- Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc
- (2008) Rosa Puca et al. EXPERIMENTAL CELL RESEARCH
- The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
- (2008) T. Terzian et al. GENES & DEVELOPMENT
- Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
- (2008) J. E. Kravchenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
- (2008) F. M. Boeckler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started